Reducing the Risk of Invasive Pathogens to Wildlife Health in the United States

Call to Action In keeping with action items 4.3.1 and 4.3.2 of the 2016–2018 National Invasive Species Council (NISC) Management Plan, the Wildlife Health Task Team of the Invasive Species Advisory Committee (ISAC) was charged with: 1) identifying the major areas of vulnerability to native wildlife from the introduction and spread of invasive pathogens, and 2) making recommendations to address these vulnerabilities, including through potential changes in statute, regulation, policy, or practice of the relevant agencies

Brief Report: The Value of a Patient Global Assessment of Disease Activity in Granulomatosis With Polyangiitis (Wegener's)

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102695/1/art38248.pd

STEREO and ACE observations of CIR particles

In the present solar minimum, corotating interaction regions (CIRs) produce frequent particle enhancements at 1 AU as observed at STEREO and ACE. As the two STEREO spacecraft move apart, differences in CIR time profiles observed at each spacecraft are becoming large. The timing differences are often roughly similar to the corotation time lag between the two spacecraft, however many of the features seen at Ahead and Behind require more than just a time shift. Perhaps transient disturbances in the solar wind affect connection to or transport from the shock, or temporal changes occur in the CIR shock itself. Additional timing differences of >1 day result from the different heliographic latitudes of the two STEREO spacecraf

Evaluating the Ability of Constructed Intertidal Eastern Oyster (\u3ci\u3eCrassostrea virginica\u3c/i\u3e) Reefs to Address Shoreline Erosion in South Carolina

The application of nature-based solutions to address shoreline erosion and the loss of salt marsh in coastal South Carolina has centered around the creation of intertidal oyster (Crassostrea virginica) reefs that act as natural breakwaters. The installation of such living shoreline materials often results in a rapid accumulation of fine sediments, followed by wild oyster recruitment to suitable materials, and then more gradually the growth of salt marshes (primarily Spartina alterniflora). Leveraging more than two decades of oyster reef restoration and living shorelines research at the South Carolina Department of Natural Resources, this study quantitatively assessed performance rates for both percent oyster cover and marsh protection in relation to reef age. Determining such rates will serve to inform the expectations of prospective adopters of living shorelines as to the timeframes of some of the biological processes, as measures of performance success, that will occur following material installation. Performance success was investigated in terms of recruitment of oysters to installed materials and the creation of new marsh habitat or protection of existing marsh from erosion. Reef age was an important determinant of reef “success”, with significant relationships between reef age and both performance success metrics. Percent oyster cover reached 40% by two years post-installation and 50% by four years post-installation, indicative of high rates of oyster recruitment. The relative marsh protection rate of living shorelines compared to unprotected reference plots was 0.4 m yr-1 Reef performance differed based on bank substrate firmness, bank width, shoreline morphology, and location relative to the Intracoastal Waterway (ICW). Firmer bank substrate was associated with greater percent oyster cover. Broader bank width was associated with greater marsh protection. Higher percent oyster cover measurements were observed on straight, natural shorelines and reefs located along the ICW. Reefs located on the ICW were also associated with greater marsh protection than reefs at non-ICW sites. Further, this study demonstrates that bagged oyster shell reefs are capable of providing shoreline protection services for more than a decade and can endure multiple intense storm events. The results of this study were also used to facilitate the implementation of new living shoreline regulations in coastal South Carolina in the hope of broadening adoption of this approach to addressing shoreline erosion and salt marsh habitat loss

The Relationship Between Attenuated Plaque Identified by Intravascular Ultrasound and No-Reflow After Stenting in Acute Myocardial Infarction

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Comparison of debulking followed by stenting versus stenting alone for saphenous vein graft aortoostial lesions: immediate and one-year clinical outcomes

AbstractOBJECTIVESWe compared in-hospital and one-year clinical outcomes in patients undergoing debulking followed by stent implantation versus stenting alone for saphenous vein graft (SVG) aortoostial lesions.BACKGROUNDStent implantation in SVG aortoostial lesions may improve procedural and late clinical outcomes. However, the impact of debulking before stenting in this complex lesion subset is unknown.METHODSWe studied 320 consecutive patients (340 SVG aortoostial lesions) treated with Palmaz-Schatz stents. Debulking with excimer laser or atherectomy was performed in 133 patients (139 lesions) before stenting (group I), while 187 patients (201 lesions) underwent stent implantation without debulking (group II). Procedural success and late clinical outcomes were compared between the groups.RESULTSOverall procedural success (97.6%) was similar between the groups. Procedural complications were also similar (2.2% for group I and 2.6% for group II). At one-year follow-up, target lesion revascularization (TLR) was 19.4% for group I and 18.2% for group II (p = 0.47). There was no difference in cumulative death or Q wave myocardial infarction between the groups. Overall cardiac event-free survival was similar (69% for group I and 68% for group II). By Cox regression analysis, the independent predictors of late cardiac events were final lumen cross-sectional area (CSA) by intravascular ultrasound (IVUS) (p = 0.001) and restenotic lesions (p = 0.01). Similarly, final IVUS lumen CSA (p = 0.0001) and restenotic lesions (p = 0.006) were found to predict TLR at one year.CONCLUSIONSThese results suggest that, in most patients with SVG aortoostial lesions, debulking before stent implantation may not be necessary

Assessment of the item selection and weighting in the Birmingham Vasculitis Activity Score for Wegener's Granulomatosis

Objective To assess the Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG) with respect to its selection and weighting of items. Methods This study used the BVAS/WG data from the Wegener's Granulomatosis Etanercept Trial. The scoring frequencies of the 34 predefined items and any “other” items added by clinicians were calculated. Using linear regression with generalized estimating equations in which the physician global assessment (PGA) of disease activity was the dependent variable, we computed weights for all predefined items. We also created variables for clinical manifestations frequently added as other items, and computed weights for these as well. We searched for the model that included the items and their generated weights yielding an activity score with the highest R 2 to predict the PGA. Results We analyzed 2,044 BVAS/WG assessments from 180 patients; 734 assessments were scored during active disease. The highest R 2 with the PGA was obtained by scoring WG activity based on the following items: the 25 predefined items rated on ≥5 visits, the 2 newly created fatigue and weight loss variables, the remaining minor other and major other items, and a variable that signified whether new or worse items were present at a specific visit. The weights assigned to the items ranged from 1 to 21. Compared with the original BVAS/WG, this modified score correlated significantly more strongly with the PGA. Conclusion This study suggests possibilities to enhance the item selection and weighting of the BVAS/WG. These changes may increase this instrument's ability to capture the continuum of disease activity in WG.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/60211/1/23707_ftp.pd