Vesicle Priming and Depriming A SNAP Decision

AbstractSynapses have a limited pool of vesicles that are docked and primed for rapid release. In neuroendocrine cells, splice variants of the SNARE protein SNAP-25 and phosphorylation of SNAP-25 independently influence the size of the releasable vesicle pool, possibly by altering the rate of vesicle depriming. Pre- and posttranslational modifications of SNAP-25 may therefore affect synaptic strength

Developing guidance for the appropriate use of Computed Tomography within a hybrid imaging environment

The introduction of Computed Tomography (CT) within the nuclear medicine environment over the last decade has led to a dramatic increase in the number of hybrid imaging installations within the United Kingdom. Modern multislice Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET)/CT units now have the diagnostic capability to provide a high level of anatomical information and have redefined the physical environment required for this imaging modality. This alongside current financial pressures impacting on the NHS has begun to challenge traditional working practices and an increased emphasis is now being placed on the healthcare practitioner to provide high quality care, demonstrate greater clinical effectiveness, improve safe working practices and to continuously adapt their skills to meet with the changing needs of the patient. Initial research conducted by the authors in collaboration with existing clinical nuclear medicine practitioners has indicated variation in the optimal use of CT within a hybrid-imaging environment. It is a concern that this apparent position within the hybrid imaging community does not appear to be conducive with current government initiatives related to optimal service provision. These inconsistencies would therefore appear to highlight the need for the development of a competency based framework that would provide the practitioner with the opportunity to develop their own working practices and help promote the harmonised use of CT within the hybrid imaging environment

West German Political Parties and the Reunification Issue

Political Scienc

Irrigation and drainage in the new millennium

Presented at the 2000 USCID international conference, Challenges facing irrigation and drainage in the new millennium on June 20-24 in Fort Collins, Colorado.Includes bibliographical references.Washington State University is implementing a Scientific Irrigation Scheduling (SIS) Project that is being funded by the public utility districts through the Northwest Energy Efficiency Alliance (1998 through 2000). Scientific irrigation scheduling is defined as the use of crop evapotranspiration data and soil moisture sensors to accurately determine when and how much to irrigate. The project goal is market transformation. In other words, scientific irrigation scheduling will become a common practice that does not require continual government subsidy to be maintained. A 50% adoption rate will be a key indicator of market transformation in scientific irrigation scheduling. Surveys were conducted during 1997 and 1998 to determine the status of and direction for scientific irrigation scheduling in Washington. According to the survey results, private consultants were contracted to perform irrigation scheduling on nearly 300,000 acres per year. Conservation Districts, county extension, and the National Resource Conservation Service have assisted producers in scheduling irrigation on an additional 15,000 acres per year. Individual Farm enterprises reported scheduling another 55,000 acres of irrigation on their own. The combined effort has resulted in a 17% adoption rate of scientific irrigation scheduling on an acreage basis. Survey results also indicated that potatoes and tree fruit account for more than half of the acreage being scheduled. The main reason producers were willing to pay for irrigation scheduling is to insure the quality of high-value crops. Energy savings became important when water needed to be lifted a considerable distance; however, water conservation, high yield, fertilizer savings, and non-point pollution reduction were considered secondary benefits. Center-pivots were the most likely irrigation systems to be scheduled and a considerable proportion of drip and solid set sprinklers were scheduled, but a very small proportion of furrow systems and set-move sprinklers were scheduled. Of the producers who irrigated farms smaller than 1,000 acres, 75% of the survey respondents have personal computers and 50% have modems but less than 5% are using their computers to schedule irrigation. Since computers and communication technology are available "on-farm," Washington Irrigation Scheduling Expert (WlSE) has been developed as a web-linked and user-friendly software tool that brings together all the pieces needed to implement irrigation scheduling. WISE, soil moisture sensors and other tools will be promoted via traditional demonstration and educational methods but with a different emphasis. Instead of offering irrigators a free service, cooperators will be encouraged to produce their own irrigation schedules from the onset of their involvement with the SIS project and agricultural supply companies will be encouraged to add irrigation scheduling to their services. The goal of this paper and presentation is to document the status, tools, and progress of market transformation in Washington's SIS Project

Additions to the plume moth fauna of The Bahamas (Lepidoptera: Pterophoridae) with description of four new species

Records of Bahamas plume moths (Lepidoptera: Pterophoridae) collected since 2011 are summarized and four new species described: Michaelophorus salensis Matthews, new species, Oidaematophorus androsensis Matthews, new species, Hellinsia bahamensis Matthews, new species, and Hellinsia lucayana Matthews, new species. Species accounts including illustrations of adults and genitalia, diagnoses, larval hosts, habitats, and distributions are provided. Of the 23 species found, new larval host associations are reported for two species while the life histories remain unknown for seven species

Observations of plume moths on North Andros Island, Bahamas, and notes on new records and species previously recorded from the Bahamas (Lepidoptera: Pterophoridae)

Recent fieldwork on North Andros Island by the authors resulted in the collection of six species of Pterophoridae (Lepidoptera), five of which were previously unrecorded for the Bahamas in published accounts. Three additional species are noted for the Bahamian fauna based on specimens collected in the 1980s on other islands. Representative specimens are illustrated from North Andros along with genitalic images for species where these are not readily available in other publications. In addition, images of the larva and pupa are provided for a reared species for which the life history was previously unknown

A UVB Wavelength Dependency for Local Suppression of Recall Immunity in Humans Demonstrates a Peak at 300nm

UVB radiation is a potent environmental carcinogen that not only causes mutations in the skin but also profoundly suppresses skin immune responses. Although this UVB-induced suppression of antitumor immunity has a key role in skin cancer development, the wavelengths within UVB causing greatest in vivo immunosuppression in humans are as yet unknown. We have identified a wavelength dependency for immunosuppression in humans across the UVB spectrum. We established linear dose–response curves for UV-induced local suppression of recall contact hypersensitivity responses at four wavelengths between 289 and 322nm and found peak immune suppressive effectiveness at 300nm and no detectable suppression at 322nm within a physiologically relevant dose range