A Model for Forecasting Pollution Prevention Life Cycle Costs for Air Force Major Weapon Systems

This research effort developed a modification to the HAZMAT program so that the program could provide the user with the capability to generate an estimate during the concept exploration and design phases for the total costs associated with hazardous materials usage in a major weapon system. Using the HAZMAT database, a spreadsheet was developed which projects a cost for a weapon system based on its total surface area and the number of aircraft to be produced by performing an analogy with a similar weapon system. The modification uses algorithm which are based on the hazardous material substances rather than processes which use hazardous materials. This enables the user to eliminate various substances entirely from the weapon system rather than trying to identity every process which uses a particular substance. The modification was identified to be the most efficient method of calculating an estimate during the early phases of the life cycle through in depth interviews and analysis of existing literature on the subject. The authors feel that the methods discovered in this thesis will provide insight for future revisions of HAZMAT and new attempts to formulate a life cycle cost model for hazardous materials

Can false memories prime alternative solutions to ambiguous problems?

Research has demonstrated that false memories are capable of priming and facilitating insight-based problem-solving tasks by increasing solution rates and decreasing solution times. The present research extended this finding by investigating whether false memories could be used to bias ambiguous insight-based problem-solving tasks in a similar manner. Compound remote associate task (CRAT) problems with two possible correct answers, a dominant and a non-dominant solution, were created and normed (Experiment 1). In Experiment 2, participants were asked to solve these CRAT problems after they were given Deese/Roediger-McDermott lists whose critical lures were also the non-dominant solution to half of the corresponding CRATs. As predicted, when false memories served as primes, solution rates were higher and solution times were faster for non-dominant than dominant CRAT solutions. This biasing effect was only found when participants falsely recalled the critical lure, and was not found when participants did not falsely recall the critical lure, or when they were not primed. Results are discussed with regard to spreading activation models of solution competition in problem-solving tasks and current theories of false memory priming effects

Partnering for Quail in South Carolina: A Cooperative Approach Making a Difference

The National Bobwhite Conservation Initiative (NBCI) identified 15 national quail focal areas throughout the distribution of the northern bobwhite (Colinus virginianus) in June 2016. The first NBCI Focal Area on U.S. Forest Service System land emerged from the existing 16,200-hectare Indian Creek Woodland and Savanna Restoration Initiative (ICWSRI). The ICWSRI is an ongoing collaborative project involving partners from 10 agencies and organizations in the Piedmont of South Carolina. Cooperation among federal and state agencies, non-governmental organizations (NGO), and private landowners, combined with assistance programs such as the Environmental Quality Incentives Program (EQIP) have currently resulted in 2,547 hectares (1,600 hectares on private land and 947 hectares on public land) of improved habitat for wildlife species associated with pine woodlands and savannas. Data obtained through the Breeding Bird Survey, spring whistle counts, and fall covey counts suggest a correlation between woodland and savanna restoration and avian response across the ICWSRI area. Fall covey count minimum population estimates (birds/ha) ranged from 1/38 in 2008 to 1/7 in 2016. Spring whistle count population density estimates (birds/ha) ranged from 1/37 in 2009 to 1/6 in 2012. Although monitoring suggests an initial increase in bobwhite densities across the project area, it is imperative to continue involving existing and additional partners to increase habitat availability, connectivity, and quality for bobwhite and associated species. Collaborative efforts and partnerships across ownership boundaries are necessary to increase bobwhite populations on a landscape scale. The Indian Creek project has effectively involved efforts from federal, state, NGO, and private partners to restore and improve bobwhite habitat and may serve as an example for other areas where incorporating a cooperative approach could positively influence bobwhite populations

Deriving on-road spatial vehicle emission profiles from chassis dynamometer experiments

A method has been derived for the identification of spatial emission hot-spots on vehicle road routes using chassis dynamometer data. The work presented here uses tailpipe-out carbon monoxide (CO) levels to demonstrate the application of the method. The approach is used to analyse critically methods used by legislators that derive road-side emission levels from the vehicle emission inventory and legislative emission levels. The work presented in this paper demonstrates that the generic approach using vehicle speed, gear change patterns, spatial geographical data, and route geometric information is sufficient for the identification of the location of emission hot-spots in any journey route of interest

Real-world performance of catalytic converters

This paper investigates experimentally the performance of a three-way catalytic (TWC) converter for real-world passenger car driving in the United Kingdom. A systematic approach is followed for the analysis using a Euro-IV vehicle coupled with a TWC converter. The analysis shows that the real-world performance of TWC converters is significantly different from the performance established on legislative test cycles. It is identified that a light-duty passenger vehicle certified for Euro-IV emissions reaches the gross polluting threshold limits during real-world driving conditions. This result is shown to have implications for overall emission levels and the use of remote emissions sensing and on-board diagnostics (OBD) systems

Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based ‘click’ ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for selectivity in binding at the interface between tandem quadruplex motifs

Microbiome function predicts amphibian chytridiomycosis disease dynamics

[Background] The fungal pathogenBatrachochytrium dendrobatidis (Bd) threatens amphibian biodiversity and ecosystem stability worldwide. Amphibian skin microbial community structure has been linked to the clinical outcome of Bd infections, yet its overall functional importance is poorly understood. [Methods] Microbiome taxonomic and functional profiles were assessed using high-throughput bacterial 16S rRNA and fungal ITS2 gene sequencing, bacterial shotgun metagenomics and skin mucosal metabolomics. We sampled 56 wild midwife toads (Alytes obstetricans) from montane populations exhibiting Bd epizootic or enzootic disease dynamics. In addition, to assess whether disease-specific microbiome profiles were linked to microbe-mediated protection or Bd-induced perturbation, we performed a laboratory Bd challenge experiment whereby 40 young adult A. obstetricans were exposed to Bd or a control sham infection. We measured temporal changes in the microbiome as well as functional profiles of Bd-exposed and control animals at peak infection. [Results] Microbiome community structure and function differed in wild populations based on infection history and in experimental control versus Bd-exposed animals. Bd exposure in the laboratory resulted in dynamic changes in microbiome community structure and functional differences, with infection clearance in all but one infected animal. Sphingobacterium, Stenotrophomonas and an unclassified Commamonadaceae were associated with wild epizootic dynamics and also had reduced abundance in laboratory Bd-exposed animals that cleared infection, indicating a negative association with Bd resistance. This was further supported by microbe-metabolite integration which identified functionally relevant taxa driving disease outcome, of which Sphingobacterium and Bd were most influential in wild epizootic dynamics. The strong correlation between microbial taxonomic community composition and skin metabolome in the laboratory and field is inconsistent with microbial functional redundancy, indicating that differences in microbial taxonomy drive functional variation. Shotgun metagenomic analyses support these findings, with similar disease-associated patterns in beta diversity. Analysis of differentially abundant bacterial genes and pathways indicated that bacterial environmental sensing and Bd resource competition are likely to be important in driving infection outcomes. [Conclusions] Bd infection drives altered microbiome taxonomic and functional profiles across laboratory and field environments. Our application of multi-omics analyses in experimental and field settings robustly predicts Bd disease dynamics and identifies novel candidate biomarkers of infection. [MediaObject not available: see fulltext.]K.A.B. was funded by a CASE studentship from NERC, NERC Biomolecular Analysis Facility grant (NBAF939) and an E.P. Abraham Junior Research Fellowship from St Hilda’s College, University of Oxford. M.C.F and T.W.J.G. were funded by NERC award NE/E006701/1 and the Biodiversa project RACE: Risk Assessment of Chytridiomycosis to European Amphibian Biodiversity. T.W.J.G was also funded by Research England and NERC NE/S000062/1. D.S.S. and A.L. received funding through the project People, Pollution, and Pathogens financed through the call “Mountains as Sentinels of Change” by the Belmont-Forum (ANR-15-MASC-0001 - P3, DFG-SCHM3059/6-1, NERC-1633948, NSFC-41661144004). D.S.S. holds the AXA Chair for Functional Mountain Ecology funded by the AXA Research Fund through the project GloMEc and M.C.F. is a fellow in the CIFAR ‘Fungal Kingdoms’ Program

Effect of Zephyr Endobronchial Valves on Dyspnea, Activity Levels, and Quality of Life at One Year Results from a Randomized Clinical Trial

Rationale: Bronchoscopic lung volume reduction with Zephyr Valves improves lung function, exercise tolerance, and quality of life of patients with hyperinflated emphysema and little to no collateral ventilation. Objectives: Post hoc analysis of patient-reported outcomes (PROs), including multidimensional measures of dyspnea, activity, and quality of life, in the LIBERATE (Lung Function Improvement after Bronchoscopic Lung Volume Reduction with Pulmonx Endobronchial Valves used in Treatment of Emphysema) study are reported. Methods: A total of 190 patients with severe heterogeneous emphysema and little to no collateral ventilation in the target lobe were randomized 2:1 to the Zephyr Valve or standard of care. Changes in PROs at 12 months in the two groups were compared: dyspnea with the Transitional Dyspnea Index (TDI), focal score; the Chronic Obstructive Pulmonary Disease Assessment Test (CAT; breathlessness on hill/stairs); Borg; the EXAcerbations of Chronic pulmonary disease Tool-PRO, dyspnea domain; activity with the TDI, magnitude of task/effort/functional impairment, CAT (limited activities), and the St. George's Respiratory Questionnaire (SGRQ), activity domain; and psychosocial status with the SGRQ, impacts domain, and CAT (confidence and energy). Results: At 12 months, patients using the Zephyr Valve achieved statistically significant and clinically meaningful improvements in the SGRQ; CAT; and the TDI, focal score, compared with standard of care. Improvements in the SGRQ were driven by the impacts and activity domains (P, 0.05 and P, 0.001, respectively). Reduction in CAT was through improvements in breathlessness (P, 0.05), energy level (P, 0.05), activities (P, 0.001), and increased confidence when leaving home (P, 0.05). The TDI measures of effort, task, and functional impairment were uniformly improved (P, 0.001). The EXAcerbations of Chronic Pulmonary Disease Tool (EXACT)-PRO, dyspnea domain, was significantly improved in the Zephyr Valve group. Improvements correlated with changes in residual volume and residual volume/TLC ratio. Conclusions: Patients with severe hyperinflated emphysema achieving lung volume reductions with Zephyr Valves experience improvements in multidimensional scores for breathlessness, activity, and psychosocial parameters out to at least 12 months