A systemic approach to the database marketing process

The role of database marketing (DBM) has become increasingly important for organisations that have large databases of information on customers with whom they deal directly. At the same time, DBM models used in practice have increased in sophistication. This paper examines a systemic view of DBM and the role of analytical techniques within DBM. It extends existing process models to develop a systemic model that encompasses the increased complexity of DBM in practice. The systemic model provides a framework to integrate data mining, experimental design and prioritisation decisions. This paper goes on to identify opportunities for research in DBM, including DBM process models used in practice, the use of evolutionary operations techniques in DBM, prioritisation decisions, and the factors that surround the uptake of DBM.<br /

Mechanization of a High Aspect Ratio Wing for Aerodynamic Control

Investigations are conducted to mechanize a controlled spanwise-varying airfoil camber change for a high aspect ratio wing, resulting in optimized aerodynamic performance for a aircraft that changes weight by 50% over its mission. Mechanisms to achieve these shape changes are designed based on two separate design methodologies: a rigid body kinematics approach and a compliant mechanism approach. A framework for optimizing mechanisms based on each approach is presented. Differences between the approaches are illustrated through the design of a mechanism for a specific set of airfoil shapes. Mechanisms are evaluated based on the error in the shapes and on the energy efficiency of the systems

The Ursinus Weekly, April 9, 1962

Junior class goes Parisian for Sunnybrook event Friday • Wurster elected YMCA president • Dr. Helfferich elected as UCC educators treasurer • Coeds tap Taney, Hartzell, Andrews for prexy posts • Pre-medicals hear Hahneman\u27s Bondi on chemotherapy • Sophomores slate weekend wingding • Thousands visit science fair at Ursinus College • Forum to present Sokoloffs in piano recital Wednesday • Pi Nu will sponsor music month here • Weekly banquet is Swint\u27s swansong • Moll announces MSGA now accepting petitions for 1962 membership • Editorial: A matter of policy; Is it worth it, men? • Letters to the editor • Next war praised; Bravo for Mackey • Meistersinger reports progress of New England tour via phone call • Conservative coed goes Dixie-way • Fighting Shaner leads Siebmen in sloppy 11-7 victory over Dickinson • Cindermen drop practice meet to Lehighers, 64 to 54 • Intramural corner • Dryfoos named outstanding player by coaches of MAC college division • Snyder places second in chess tournament • Greek gleanings • Miss Pennsylvania betroths UC grad • Final student concert spots Prokofieff work • Graduate grantshttps://digitalcommons.ursinus.edu/weekly/1316/thumbnail.jp

Gene expression signatures predict response to therapy with growth hormone

Xarxes reguladores de gens; Marcadors predictiusRedes reguladoras de genes; Marcadores predictivosGene regulatory networks; Predictive markersRecombinant human growth hormone (r-hGH) is used as a therapeutic agent for disorders of growth including growth hormone deficiency (GHD) and Turner syndrome (TS). Treatment is costly and current methods to model response are inexact. GHD (n = 71) and TS patients (n = 43) were recruited to study response to r-hGH over 5 years. Analysis was performed using 1219 genetic markers and baseline (pre-treatment) blood transcriptome. Random forest was used to determine predictive value of transcriptomic data associated with growth response. No genetic marker passed the stringency criteria for prediction. However, we identified an identical set of genes in both GHD and TS whose expression could be used to classify therapeutic response to r-hGH with a high accuracy (AUC > 0.9). Combining transcriptomic markers with clinical phenotype was shown to significantly reduce predictive error. This work could be translated into a single genomic test linked to a prediction algorithm to improve clinical management. Trial registration numbers: NCT00256126 and NCT00699855.This work was supported by Merck KGaA, Darmstadt, Germany

The Ursinus Weekly, November 6, 1961

Juniors elect Ruby editors; O\u27Donnell, Wurster named • Fashions and fabrics constitute WSGA\u27s Design for Living show • Ursinus\u27 Minnich representative at fitness meeting • Twelve men sign fraternity bids • PSEA schedules Eugene Bertin for speech tomorrow • Forum features Senator Clark Wednesday night • Duryea girls\u27 display Homecoming\u27s finest • Sandy Holl chosen Fall queen; Bears win Homecoming tilt • U.C. Newman Club to hear Pottstown\u27s Father Heim • Editorial: Dropped column; Extra edition • Ferguson, Wirth chosen \u2765 MSGA representatives • Katharine Gibbs School offers two national grants • Bloom on the Gordon-Davis towel • Ursinus in the past • Student concert presents Ormandy • French villages reward tourists with quaint charm, lovely scenes • Booters tie Fords in overtime, 2-2; Alumni loses, 5-2 • Gridders roll over Haverford, 22-6; Quinn passes for two touchdowns • Beaver beaten, 3-1 by hockey girls • Senior fullback Gary Leach wins Walker trophy for fine play Saturday • Consulate posts offered by U.S. State Department • Few local contests in general election Nov. 7 • Dr. R. L. Shinn speaks on Christian faith • Remig names Mrs. Bosler as janitorial coordinator • Chief McClure reports on October police work • Pre-meds attend Hahnemann talks; Club also hears pathology professorhttps://digitalcommons.ursinus.edu/weekly/1303/thumbnail.jp

The Ursinus Weekly, November 6, 1961

Juniors elect Ruby editors; O\u27Donnell, Wurster named • Fashions and fabrics constitute WSGA\u27s Design for Living show • Ursinus\u27 Minnich representative at fitness meeting • Twelve men sign fraternity bids • PSEA schedules Eugene Bertin for speech tomorrow • Forum features Senator Clark Wednesday night • Duryea girls\u27 display Homecoming\u27s finest • Sandy Holl chosen Fall queen; Bears win Homecoming tilt • U.C. Newman Club to hear Pottstown\u27s Father Heim • Editorial: Dropped column; Extra edition • Ferguson, Wirth chosen \u2765 MSGA representatives • Katharine Gibbs School offers two national grants • Bloom on the Gordon-Davis towel • Ursinus in the past • Student concert presents Ormandy • French villages reward tourists with quaint charm, lovely scenes • Booters tie Fords in overtime, 2-2; Alumni loses, 5-2 • Gridders roll over Haverford, 22-6; Quinn passes for two touchdowns • Beaver beaten, 3-1 by hockey girls • Senior fullback Gary Leach wins Walker trophy for fine play Saturday • Consulate posts offered by U.S. State Department • Few local contests in general election Nov. 7 • Dr. R. L. Shinn speaks on Christian faith • Remig names Mrs. Bosler as janitorial coordinator • Chief McClure reports on October police work • Pre-meds attend Hahnemann talks; Club also hears pathology professorhttps://digitalcommons.ursinus.edu/weekly/1303/thumbnail.jp

The Ursinus Weekly, October 23, 1961

Lettinger to lead freshmen; Kelly elected vice-president • Sororities accept sixty new sisters • Two rediscovered works highlight woodwind five\u27s Bomberger performance • Minnich, Weiss win state Young Republican offices • Lawrence calls collegians for press conference: Weekly editor represents Ursinus at Capitol confab • Ursinus to hear Maine\u27s Senator Smith; Receives honorary degree on Founders Day • Efficiency, devotion to duty mark Margaret Chase Smith • Pradervand, Zabarah come to Ursinus from Switzerland, Yemen for studies • President lauds Parents Day; Excellent preparations cited • Editorial: Credit where credit is due • Ursinus in the past • Education by travel • Letters to the editor • 30 yard run breaks Bears backs following 12-6 victory over Wilkes • Hockey lassies remain unbeaten; Defeat Swarthmore, tie Temple girls • Bakermen boot first foes; Lose third tilt to Hens, 2-0 • Hakanson\u27s heft plugs defensive hole; Massachusetts man UC\u27s middle guard • Dean Kellow talks on medical school • Dr. Armstrong organizing second European Tour • German Club members get first-hand Berlin accounthttps://digitalcommons.ursinus.edu/weekly/1301/thumbnail.jp

Expanding the Operational Use of Total Lightning Ahead of GOES-R

NASA's Shortterm Prediction Research and Transition Center (SPoRT) has been transitioning realtime total lightning observations from groundbased lightning mapping arrays since 2003. This initial effort was with the local Weather Forecast Offices (WFO) that could use the North Alabama Lightning Mapping Array (NALMA). These early collaborations established a strong interest in the use of total lightning for WFO operations. In particular the focus started with warning decision support, but has since expanded to include impactbased decision support and lightning safety. SPoRT has used its experience to establish connections with new lightning mapping arrays as they become available. The GOESR / JPSS Visiting Scientist Program has enabled SPoRT to conduct visits to new partners and expand the number of operational users with access to total lightning observations. In early 2014, SPoRT conducted the most recent visiting scientist trips to meet with forecast offices that will used the Colorado, Houston, and Langmuir Lab (New Mexico) lightning mapping arrays. In addition, SPoRT met with the corresponding Center Weather Service Units (CWSUs) to expand collaborations with the aviation community. These visits were an opportunity to learn about the forecast needs of each office visited as well as to provide onsite training for the use of total lightning, setting the stage for a realtime assessment during MayJuly 2014. With five lightning mapping arrays covering multiple geographic locations, the 2014 assessment has demonstrated numerous uses of total lightning in varying situations. Several highlights include a much broader use of total lightning for impactbased decision support ranging from airport weather warnings, supporting fire crews, and protecting large outdoor events. The inclusion of the CWSUs has broadened the operational scope of total lightning, demonstrating how these data can support air traffic management, particularly in the Terminal Radar Approach Control Facilities (TRACON) region around an airport. These collaborations continue to demonstrate, from the operational perspective, the utility of total lightning and the importance of continued training and preparation in advance of the Geostationary Lightning Mapper

Reduction of Malaria Transmission to Anopheles Mosquitoes with a Six-Dose Regimen of Co-Artemether

BACKGROUND: Resistance of malaria parasites to chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) is increasing in prevalence in Africa. Combination therapy can both improve treatment and provide important public health benefits if it curbs the spread of parasites harbouring resistance genes. Thus, drug combinations must be identified which minimise gametocyte emergence in treated cases, and so prevent selective transmission of parasites resistant to any of the partner drugs. METHODS AND FINDINGS: In a randomised controlled trial, 497 children with uncomplicated falciparum malaria were treated with CQ and SP (three doses and one dose respectively; n = 91), or six doses of artemether in fixed combination with lumefantrine (co-artemether [Coartem, Riamet]) (n = 406). Carriage rates of Plasmodium falciparum gametocytes and trophozoites were measured 7, 14, and 28 d after treatment. The infectiousness of venous blood from 29 children carrying P. falciparum gametocytes 7 d after treatment was tested by membrane-feeding of Anopheles mosquitoes. Children treated with co-artemether were significantly less likely to carry gametocytes within the 4 weeks following treatment than those receiving CQ/SP (30 of 378 [7.94%] versus 42 of 86 [48.8%]; p < 0.0001). Carriers in the co-artemether group harboured gametocytes at significantly lower densities, for shorter periods (0.3 d versus 4.2 d; p < 0.0001) and were less infectious to mosquitoes at day 7 (p < 0.001) than carriers who had received CQ/SP. CONCLUSIONS: Co-artemether is highly effective at preventing post-treatment transmission of P. falciparum. Our results suggest that co-artemether has specific activity against immature sequestered gametocytes, and has the capacity to minimise transmission of drug-resistant parasites

Whiteness and loss in outer East London: tracing the collective memories of diaspora space

This paper explores collective memory in Newham, East London. It addresses how remembering East London as the home of whiteness and traditional forms of community entails powerful forms of forgetting. Newham's formation through migration – its ‘great time’ – has ensured that myths of indigeneity and whiteness have never stood still. Through engaging with young people's and youth workers' memory practices, the paper explores how phantasms of whiteness and class loss are traced over, and how this tracing reveals ambivalence and porosity, at the same time as it highlights the continued allure of race. It explores how whiteness and class loss are appropriated across ethnic boundaries and how they are mobilized to produce new forms of racial hierarchy in a ‘super-diverse’ place