Volatile Interest Rates, Volatile Crime Rates: A new argument for interest-rate smoothing

Good monetary policy requires estimates of all of its effects: monetary policy impacts traditional economic variables such as output, unemployment rates, and inflation. But does monetary policy influence crime rates? By extending the vector autoregression literature, we derive estimates of the dynamic effect of higher interest rates on crime rates. Higher interest rates have socially and statistically significant positive effects on rates of theft and knife robberies, while effects on rates of burglary and assault are smaller and statistically insignificant. Higher interest rates have no effect on homicide rates. We conclude that monetary policy influences the rate of economically-motivated crimes.http://deepblue.lib.umich.edu/bitstream/2027.42/40080/3/wp694.pd

Mephenesin carbamate in the treatment of spastic paralysis

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Method for suppressing noise in measurements

Techniques of combining separate but correlated measurements to form a second-order or higher order correlation function to suppress the effects of noise in the initial condition of a system capable of retaining memory of an initial state of the system with a characteristic relaxation time. At least two separate measurements are obtained from the system. The temporal separation between the two separate measurements is preferably comparable to or less than the characteristic relaxation time and is adjusted to allow for a correlation between two measurements

An Evaluation Of Static and Dynamic Yoga Training Programs

While traditional yoga programs focus on static stretching and core stability, Essentrics yoga relies more heavily on full-body stretch and strengthening regiments coupled with dynamic movements such as ceiling reaches, side-to-side bends, lunges, and side leg lifts. Through the incorporation of more dynamic movements, Essentrics yoga is thought to elicit greater improvements in overall body composition, flexibility, and balance. PURPOSE: To examine the benefits of a 6-weeks long Essentrics (dynamic) program compared to standard (static) Yoga on body composition, flexibility, and balance. METHODS: Thirty-one participants (24 females and 7 males, age = 20.4 ± 0.2yrs, and BMI = 22.58 ± 0.55kg/m2) were assigned to two groups – a standard Yoga (YOG, n = 20) and an Essentrics (ESS, n = 11) group. For 6 weeks, both groups attended a 45–50-minute class, 3 times per week. Body composition (dual-energy x-ray absorptiometry), flexibility (sit-and-reach), balance (lower extremity Y-balance), as well anthropometric measurements were assessed at the beginning and end of the 6-week program. Measurements of the balance test included 3 reaches and their combined values [anterior (ANT), posteromedial (PM), posterolateral (PL), and composite reach distance (CRD)]. All reaches were averaged for the right and left sides and then normalized to leg length. Data were analyzed using an ANOVA with repeated measures (p \u3c 0.05), and a post-hoc test was performed if any significant main or interaction effects were found. RESULTS: Interestingly, the total body fat percentage was significantly reduced only in the YOG group (24.44 ± 6.73 to 23.51 ± 6.32%, p=.002). There were no significant group differences between YOG and ESS in balance and flexibility. However, balance was improved after the 6-week workout programs; PM (87.13 ± 11.64cm to 92.25 ± 9.91cm, p=.001), PL (82.88 ± 11.28 to 88.62 ± 9.62cm, p=.002), CRD (225.96 ± 27.17 to 238.26 ± 22.98cm, p=.001), normalized PM (98.31 ± 11.68 to 104.27 ± 11.14%, p=.001), normalized PL (93.60 ± 11.98 to 100.15 ± 10.70%, p=.001), and normalized CRD (255.12 ± 27.89 to 269.21 ± 25.07%, p=.001). Additionally, flexibility was improved from 51.42 ± 8.24 to 53.38 ± 7.04cm (p=.010) after the 6-week workout programs, while total body fat percentage was significantly reduced only in the YOG group (24.44 ± 6.73 to 23.51 ± 6.32%, p=.002). CONCLUSION: Whether an individual prefers a static or dynamic yoga program, both show improvements in flexibility and balance; however, neither program had a significant benefit over the other

Relationships Between Anthropometric Variables and the Internal Carotid Blood Flow

Assessment of peak systolic velocity (PSV) of the internal carotid artery (ICA) is utilized to examine stroke-symptomatic individuals for ICA stenosis. While a sedentary lifestyle is a common risk factor for ICA stenosis, a deeper understanding of how body composition affects ICA blood flow could provide insights before symptoms appear. PURPOSE: To examine the relationship between ICA blood flow and body composition variables. METHODS: ICA blood flow was assessed in eight healthy males (21.88 ± 2.25 years) on three different days to control for possible diurnal variability that could affect blood flow. Participants abstained from caffeine and physical activity for a minimum of 12 hours prior to each visit. Dual-energy X-ray absorptiometry was used to assess body fat percentage (BF%) and visceral fat area (VFA). Bioelectrical impedance (BIA) was used to assess body water percentage (BW%), metabolic age (MetA), and visceral fat rating (VFR). Participants rested supine with eyes closed for 5 minutes prior to assessment of ICA. B-mode doppler ultrasound sonography (7.5 MHz linear transducer) was used to measure PSV, end-diastolic velocity (EDV), resistance index (RI), and vessel diameter on the right ICA after 2 minutes of continual scanning with a 60° insonation angle. The relationship between ICA blood flow and body composition variables was examined via Pearson correlation analysis. RESULTS: BF% was positively correlated with ICA EDV (r = 0.669, p \u3c 0.001) and ICA PSV (r = 0.416, p = 0.043) but negatively correlated with ICA diameter (r = -0.424, p = 0.039). VFA was positively correlated with ICA EDV (r = 0.505, p = 0.012). BW% was negatively correlated with ICA PSV (r = -0.417, p = 0.043) and EDV (r = -0.620, p \u3c 0.001). MetA was positively correlated with ICA EDV (r = 0.630, p \u3c 0.001) but negatively correlated with ICA RI (r = -0.509, p = 0.011) and diameter (r = -0.513, p = 0.010). Similarly, VFR was positively correlated with ICA EDV (r = 0.644, p \u3c 0.001) but negatively correlated with ICA RI (r = -0.511, p = 0.011) and diameter (r = -0.496, p = 0.014). CONCLUSION: EDV has a greater correlation with body composition than PSV, suggesting that adiposity-related factors can describe ICA blood flow. Similarly, BIA might offer a solid and easy-to-attain procedure to indirectly assess ICA blood flow that warrants further research

magnetoARPES: Angle Resolved Photoemission Spectroscopy with Magnetic Field Control

Angle-Resolved Photoemission Spectroscopy (ARPES) is a premier technique for understanding the electronic excitations in conductive, crystalline matter, in which the induced photocurrent is collected and dispersed in energy and angle of emission to reveal the energy- and momentum-dependent single particle spectral function $A(\mathbf{k},\omega)$. So far, ARPES in a magnetic field has been precluded due to the need to preserve the electron paths between the sample and detector. In this paper we report progress towards "magnetoARPES", a variant of ARPES that can be conducted in a magnetic field. It is achieved by applying a microscopic probe beam ($\lesssim$ 10 $\mu$m ) to a thinned sample mounted upon a special sample holder that generates magnetic field confined to a thin layer near the sample surface. In this geometry we could produce ARPES in magnetic fields up to around $\pm$ 100 mT. The magnetic fields can be varied from purely in-plane to nearly purely out-of-plane, by scanning the probe beam across different parts of the device. We present experimental and simulated data for graphene to explore the aberrations induced by the magnetic field. These results demonstrate the viability of the magnetoARPES technique for exploring symmetry breaking effects in weak magnetic fields.Comment: 21 pages, 6 figure

Aducanumab, a Novel Anti-Amyloid Monoclonal Antibody, for the Treatment of Alzheimer’s Disease: A Comprehensive Review

Alzheimer’s disease (AD) is the most common form of dementia affecting millions of individuals, including family members who often take on the role as caregiver. This debilitating disease reportedly consumes 8% of the total United States healthcare expenditure, with medical and nursing outlays accounting for an estimated $290 billion. Cholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists have historically been the most widely used pharmacologic therapies for patients with AD, however, these drugs are not curative. This review discusses the epidemiology, pathophysiology, risk factors, presentation, and current treatment of AD followed by the role of the novel monoclonal antibody, aducanumab, in treatment of AD. Currently aducanumab is the only Food and Drug Administration (FDA) approved drug that acts to slow progression of this disease. Aducanumab is an anti-amyloid drug which functions by selectively binding amyloid aggregates in both the oligomeric and fibrillar states. Studies show aducanumab may help to restore neurological function in patients with AD by reducing beta-amyloid plaques and reestablishing neuronal calcium permeability. However, there is concern the magnitude of this drug’s benefit may only be statistically significant and not clinically significant. Despite this skepticism, aducanumab has proven to significantly decrease amyloid in all cortical brain regions examined. In summary, aducanumab has provided hope for those working toward the goal of providing patients a safe and viable treatment option in the management of AD

The Impact of Nasal Breathing During Exercise on Cerebral Blood Flow

Achieving hypercapnic-induced vasodilation while exercising can increase cerebral blood flow (CBF) to a greater extent than during normoxic conditions. Evidence suggests that nasal breathing during a maximal aerobic effort can elicit a hypercapnic condition. PURPOSE: To compare the effect of combined (CB), oral (OB), and nasal (NB) breathing on CBF during a graded maximal exercise test (GXT). METHODS: Six healthy males (age: 21.83 ± 1.00 years) abstained from physical activity and caffeine for 12+ hours prior to a GXT. Three GXTs were performed (48+ hours between each trial) using a different randomized breathing condition (CB, OB, and NB). After a warm-up, participants completed a GXT until volitional fatigue on a semi-recumbent bicycle. Stages lasted 2 minutes and increased by a pre-set wattage at 70 rpm. Respiratory gases were assessed via a metabolic cart. Throughout the GXT, ultrasound sonography (7.5 MHz linear transducer) was utilized to assess the peak systolic velocity (PSV) and vessel diameter of the internal (ICA) and external (ECA) carotid artery on the right side of the neck. A one-way ANCOVA with mean arterial blood pressure and oxygen uptake (VO2) as covariates was utilized to compare the three breathing patterns at 40%, 55%, 70%, 85%, and 100% of VO2max. Data are presented as mean ± SEM. RESULTS: The partial pressure of exhaled CO2 (PECO2) was significantly greater (p = 0.008) during NB (33.16 ± 1.37 mmHg) compared to CB (26.63 ± 1.32 mmHg) and OB (26.72 ± 1.37) at 100% VO2max. While not statistically significant, there was a greater PSV in the ICA during NB (99.72 ± 7.12 cm/s) compared to CB (87.34 ± 9.36 cm/s) and OB (89.63 ± 9.77 cm/s) at 100% VO2max. Similarly, there was a greater PSV in the ICA during NB (102.53 ± 8.07 cm/s) compared to CB (93.13 ± 7.79 cm/s) and OB (81.25 ± 7.80 cm/s) at 85% VO2max. In contrast, there was a significantly greater (p = 0.027) PSV in the ICA during NB (126.12 ± 7.51 cm/s) compared to OB (92.47 ± 7.34 cm/s) but not CB (111.91 ± 7.14 cm/s) at 70% VO2max. There were no significant differences in the PSV of the ECA nor the diameter of the ICA and ECA. CONCLUSION: NB during a GXT increased PSV in the ICA compared to CB and OB, which might be partly related to an increased systemic concentration of CO2. A greater increase in PSV in the ICA represents a greater CBF that might provide greater cognitive health benefits than while exercising with either CB or OB. Studies with a bigger sample size will provide greater statistical power to examine the benefits of increasing the PSV in the ICA and its effect on cognitive health

Evaluation of Body Fat Percentage with Vertical and Longitudinal Skinfolds

Subcutaneous fat content, as well as body fat percentage (BF%), can be effectively assessed using skinfold calipers. While skinfolds (SFs) are practical and easy to attain, their accuracy could be reduced if the SFs are not collected with the ideal fold orientation. PURPOSE: To determine if vertical or longitudinal SFs in the trunk area are better predictors of BF%. METHODS: A pool of thirty-eight male (21.29 ± 4.59 yrs, 15.68 ± 4.82 BF%) and twenty-two female (21.14 ± 4.05 yrs, 26.63 ± 5.34 BF%) participants completed the study. A dual-energy X-ray absorptiometry scan was utilized to assess BF%. Using a Lange caliper, one technician assessed all SFs within the trunk in triplicate using both a vertical pinch and a longitudinal pinch. SFs sites included: 2 cm left, right, superior, and inferior of the umbilicus; left and right anterior mid-axillary line at the level of the navel; 2 cm left and right of the vertebral column at the level of the navel; midsternal line at the slimmest part of the waist and at the level of the xiphoid process. In addition, two commonly assessed diagonal folds (right suprailiac and subscapular) were collected. The relationship between SFs orientation and BF% was assessed utilizing a Pearson correlation. Stepwise linear regression was utilized to predict BF%. Data are presented as mean ± SD. RESULTS: Overall, vertical folds for both males and females had a higher correlation with BF% than longitudinal folds. The right vertical mid-axillary (RVMA) SFs had a significant correlation with BF% for both male (r = 0.864, p \u3c 0.001) and female (r = 0.712, p \u3c 0.001) participants. Similarly, the subscapular (SS) SFs had a significant correlation with BF% for both male (r = 0.851, p \u3c 0.001) and female (r = 0.788, p \u3c 0.001) participants. BF% was successfully predicted [4.142 + (10.154 * Sex) + (0.255 * RVMA) + (0.516 * SS), adjusted R2 = 0.874], where sex (0 = male, 1 = female). The average RVMA SFs were 18.43 ± 7.85 mm for males and 19.91 ± 6.78 mm for females, while the SS SFs were 13.50 ± 4.95 mm for males and 14.05 ± 5.34 mm for females. CONCLUSION: Although RVMA SFs are not commonly utilized to estimate BF%, there is evidence of a high correlation with BF%. The applicability of utilizing the RVMA jointly with the SS SFs as a fast yet reliable method to estimate BF% should be examined in a large and diverse cohort