8,158 research outputs found
Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry
In several species, developmental skeletal diseases involving abnormal endochondral ossification have been associated with imbalanced mineral intake. Hair analysis reflects long-term mineral status. To determine the mineral content of hair from dogs with or without medial coronoid process disease (MCPD). Dogs with MCPD have a different profile of minerals known to influence metalloenzymes involved in endochondral ossification. After cleansing, chelation and acid digestion of hair samples (n=79 in total: control dogs, n=70 v MCPD, n=9), mineral profile (7 major and 25 trace elements) was determined by inductively coupled plasma-mass spectrometry. Dogs were of similar age (control, 4.05 [1.85-7.70] v MCPD, 4.30 [3.25-6.53] median (IQR) years; P=0.78) and gender (control, n=43/27 v MCPD, n=4/5 males/females). 28/70 (40 per cent) of control and 8/9 (88 per cent) of MCPD dogs were neutered, respectively. Hair from dogs with MCPD contained significantly lower amounts (µg/g/DM) of copper, sulphur and zinc (all at P<0.001). Age, sex and neutered status had no effect on hair mineral status. Based on hair analysis, a role for mineral imbalance including copper, sulphur and zinc in the aetiopathogenesis of canine MCPD is suggested. Hair mineral analysis may prove useful as a biomarker for susceptible puppies
The Population of Damped Lyman-alpha and Lyman Limit Systems in the Cold Dark Matter Model
Lyman limit and damped Lyman-alpha absorption systems probe the distribution
of collapsed, cold gas at high redshift. Numerical simulations that incorporate
gravity and gas dynamics can predict the abundance of such absorbers in
cosmological models. We develop a semi-analytical method to correct the
numerical predictions for the contribution of unresolved low mass halos, and we
apply this method to the Katz et al. (1996) simulation of the standard cold
dark matter model (, , , ). Using
this simulation and higher resolution simulations of individual low mass
systems, we determine the relation between a halo's circular velocity and
its cross section for producing Lyman limit or damped absorption. We combine
this relation with the Press-Schechter formula for the abundance of halos to
compute the number of absorbers per unit redshift. The resolution correction
increases the predicted abundances by about a factor of two at z=2, 3, and 4,
bringing the predicted number of damped absorbers into quite good agreement
with observations. Roughly half of the systems reside in halos with circular
velocities v_c>100\kms and half in halos with 35\kms. Halos
with v_c>150\kms typically harbor two or more systems capable of producing
damped absorption. Even with the resolution correction, the predicted abundance
of Lyman limit systems is a factor of three below observational estimates,
signifying either a failure of standard CDM or a failure of these simulations
to resolve the systems responsible for most Lyman limit absorption. By
comparing simulations with and without star formation, we find that depletion
of the gas supply by star formation affects absorption line statistics at
only for column densities exceeding .Comment: AASlatex, 17 pages w/ 3 embedded ps figures. Submitted to Ap
Simulations of Damped Lyman-Alpha and Lyman Limit Absorbers in Different Cosmologies: Implications for Structure Formation at High Redshift
We use hydrodynamic cosmological simulations to study damped Lyman-alpha
(DLA) and Lyman limit (LL) absorption at redshifts z=2-4 in five variants of
the cold dark matter scenario. Our standard simulations resolve the formation
of dense concentrations of neutral gas in halos with circular velocity v_c
roughly 140 km/s for Omega_m=1 and 90 km/s for Omega_m=0.4, at z=2; an
additional LCDM simulation resolves halos down to v_c approximately 50 km/s at
z=3. We find a clear relation between HI column density and projected distance
to the center of the nearest galaxy, with DLA absorption usually confined to
galactocentric radii less than 10-15 kpc and LL absorption arising out to
projected separations of 30 kpc or more. Detailed examination provides evidence
of non-equilibrium effects on absorption cross-section. If we consider only
absorption in the halos resolved by our standard simulations, then all five
models fall short of reproducing the observed abundance of DLA and LL systems
at these redshifts. If we extrapolate to lower halo masses, we find all four
models are consistent with the observed abundance of DLA systems if the the
extrapolated behavior extends to circular velocities roughly 50-80 km/s, and
they may produce too much absorption if the relation continues to 40 km/s. Our
results suggest that LL absorption is closely akin to DLA absorption, arising
in less massive halos or at larger galactocentric radii but not caused by
processes acting on a radically different mass scale.Comment: 33 pages with 10 embedded EPS figures. Substantially revised and
updated from original version. Includes new high-resolution simulations.
Accepted for publication in the Ap
Interstellar Scintillation of the Polarized Flux Density in Quasar, PKS 0405-385
The remarkable rapid variations in radio flux density and polarization of the
quasar PKS 0405-385 observed in 1996 are subject to a correlation analysis,
from which characteristic time scales and amplitudes are derived. The
variations are interpreted as interstellar scintillations. The cm wavelength
observations are in the weak scintillation regime for which models for the
various auto- and cross-correlations of the Stokes parameters are derived and
fitted to the observations. These are well modelled by interstellar
scintillation (ISS) of a 30 by 22 micro-as source, with about 180 degree
rotation of the polarization angle along its long dimension. This success in
explaining the remarkable intra-day variations (IDV)in polarization confirms
that ISS gives rise to the IDV in this quasar. However, the fit requires the
scintillations to be occurring much closer to the Earth than expected according
to the standard model for the ionized interstellar medium (IISM). Scattering at
distances in the range 3-30 parsec are required to explain the observations.
The associated source model has a peak brightness temperature near 2.0
10^{13}K, which is about twenty-five times smaller than previously derived for
this source. This reduces the implied Doppler factor in the relativistic jet,
presumed responsible to 10-20, high but just compatible with cm wavelength VLBI
estimates for the Doppler factors in Active Galactic Nuclei (AGNs).Comment: 43 pages 15 figures, accepted for ApJ Dec 200
Quasifree kaon-photoproduction from nuclei in a relativistic approach
We compute the recoil polarization of the lambda-hyperon and the photon
asymmetry for the quasifree photoproduction of kaons in a relativistic
impulse-approximation approach. Our motivation for studying polarization
observables is threefold. First, polarization observables are more effective
discriminators of subtle dynamics than the unpolarized cross section. Second,
earlier nonrelativistic calculations suggest an almost complete insensitivity
of polarization observables to distortions effects. Finally, this insensitivity
entails an enormous simplification in the theoretical treatment. Indeed, by
introducing the notion of a ``bound-nucleon propagator'' we exploit Feynman's
trace techniques to develop closed-form, analytic expressions for all
photoproduction observables. Moreover, our results indicate that polarization
observables are also insensitive to relativistic effects and to the nuclear
target. Yet, they are sensitive to the model parameters, making them ideal
tools for the study of modifications to the elementary amplitude --- such as in
the production, propagation, and decay of nucleon resonances --- in the nuclear
medium.Comment: 15 pages and 6 figures - submitted to PR
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Restructuring the Homicide Offences to Tackle Violence, Discrimination and Drugs in a Modern Society
This article argues that the current law on homicide fails to satisfy the goal of “fair labelling” leading to an indirect risk of discrimination against vulnerable members of our society who are not being consistently recognized as the victims of a fatal crime. The case is put forward for two new rungs in the homicide ladder of “aggravated murder” and “aggravated manslaughter”, along with statutory offences which directly cater for the victims of drug homicides and domestic abuse leading to a suicide
The Effect of Cone Opsin Mutations on Retinal Structure and the Integrity of the Photoreceptor Mosaic
Purpose.
To evaluate retinal structure and photoreceptor mosaic integrity in subjects with OPN1LW and OPN1MW mutations.
Methods.
Eleven subjects were recruited, eight of whom have been previously described. Cone and rod density was measured using images of the photoreceptor mosaic obtained from an adaptive optics scanning light ophthalmoscope (AOSLO). Total retinal thickness, inner retinal thickness, and outer nuclear layer plus Henle fiber layer (ONL+HFL) thickness were measured using cross-sectional spectral-domain optical coherence tomography (SD-OCT) images. Molecular genetic analyses were performed to characterize the OPN1LW/OPN1MW gene array.
Results.
While disruptions in retinal lamination and cone mosaic structure were observed in all subjects, genotype-specific differences were also observed. For example, subjects with “L/M interchange” mutations resulting from intermixing of ancestral OPN1LW and OPN1MW genes had significant residual cone structure in the parafovea (∼25% of normal), despite widespread retinal disruption that included a large foveal lesion and thinning of the parafoveal inner retina. These subjects also reported a later-onset, progressive loss of visual function. In contrast, subjects with the C203R missense mutation presented with congenital blue cone monochromacy, with retinal lamination defects being restricted to the ONL+HFL and the degree of residual cone structure (8% of normal) being consistent with that expected for the S-cone submosaic.
Conclusions.
The photoreceptor phenotype associated with OPN1LW and OPN1MW mutations is highly variable. These findings have implications for the potential restoration of visual function in subjects with opsin mutations. Our study highlights the importance of high-resolution phenotyping to characterize cellular structure in inherited retinal disease; such information will be critical for selecting patients most likely to respond to therapeutic intervention and for establishing a baseline for evaluating treatment efficacy
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Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy.
ObjectiveTo characterize individual and group-level neuroimaging findings in patients at risk for Chronic Traumatic Encephalopathy (CTE).MethodsEleven male patients meeting criteria for Traumatic Encephalopathy Syndrome (TES, median age: 64) underwent neurologic evaluation, 3-Tesla MRI, and PET with [18F]-Flortaucipir (FTP, tau-PET) and [11C]-Pittsburgh compound B (PIB, amyloid-PET). Six patients underwent [18F]-Fluorodeoxyglucose-PET (FDG, glucose metabolism). We assessed imaging findings at the individual patient level, and in group-level comparisons with modality-specific groups of cognitively normal older adults (CN). Tau-PET findings in patients with TES were also compared to a matched group of patients with mild cognitive impairment or dementia due to Alzheimer's disease (AD).ResultsAll patients with TES sustained repetitive head injury participating in impact sports, ten in American football. Three patients met criteria for dementia and eight had mild cognitive impairment. Two patients were amyloid-PET positive and harbored the most severe MRI atrophy, FDG hypometabolism, and FTP-tau PET binding. Among the nine amyloid-negative patients, tau-PET showed either mildly elevated frontotemporal binding, a "dot-like" pattern, or no elevated binding. Medial temporal FTP was mildly elevated in a subset of amyloid-negative patients, but values were considerably lower than in AD. Voxelwise analyses revealed a convergence of imaging abnormalities (higher FTP binding, lower FDG, lower gray matter volumes) in frontotemporal areas in TES compared to controls.ConclusionsMildly elevated tau-PET binding was observed in a subset of amyloid-negative patients at risk for CTE, in a distribution consistent with CTE pathology stages III-IV. FTP-PET may be useful as a biomarker of tau pathology in CTE but is unlikely to be sensitive to early disease stages
The Kinetics of Primary Alpha Plate Growth in Titanium Alloys
The kinetics of primary alpha-Ti colony/Widmanstatten plate growth from the
beta are examined, comparing model to experiment. The plate growth velocity
depends sensitively both on the diffusivity D(T) of the rate-limiting species
and on the supersaturation around the growing plate. These result in a maxima
in growth velocity around 40 K below the transus, once sufficient
supersaturation is available to drive plate growth. In Ti-6246, the plate
growth velocity was found to be around 0.32 um min-1 at 850 oC, which was in
good agreement with the model prediction of 0.36 um min-1 . The solute field
around the growing plates, and the plate thickness, was found to be quite
variable, due to the intergrowth of plates and soft impingement. This solute
field was found to extend to up to 30 nm, and the interface concentration in
the beta was found to be around 6.4 at.% Mo. It was found that increasing O
content will have minimal effect on the plate lengths expected during
continuous cooling; in contrast, Mo approximately doubles the plate lengths
obtained for every 2 wt.% Mo reduction. Alloys using V as the beta stabiliser
instead of Mo are expected to have much faster plate growth kinetics at
nominally equivalent V contents. These findings will provide a useful tool for
the integrated design of alloys and process routes to achieve tailored
microstructures.Comment: Revised version resubmitted to journa
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