Conocimiento sobre Consentimiento Informado en Odontología. Una encuesta aplicada a los odontólogos de la Universidad Europea de Valencia

Introducción: Conocer los aspectos fundamentales del consentimiento informado es imprescindible para una correcta practica clínica odontológica. Objetivo: Valorar el conocimiento de los odontólogos sobre el Consentimiento Informado y relacionarlo con género, edad y especialidad del odontólogo. Analizar la relación entre apreciación sobre la formación ética del odontólogo y el manejo de situaciones éticas en la consulta con género, edad y especialidad del odontólogo. Material y método: se aplicó un cuestionario online a los odontólogos que prestan servicio en la Clínica odontológica de la Universidad Europea de Valencia. Resultados: se analizaron 62 cuestionarios. Se obtuvo una nota ponderada de 4,27 ± 0,55 en conocimiento objetivo. Conclusiones: Los odontólogos suelen tener un nivel de conocimiento entre medio y bajo. No se ha encontrado ninguna diferencia estadísticamente significativa entre el nivel de conocimientos sobre consentimiento informado en Odontología y las variables edad, género y especialidad. La percepción que el odontólogo tiene sobre su formación ética no guarda ninguna diferencia estadísticamente significativa con edad, género y especialidad. El manejo de la situación clínica guarda una relación estadísticamente significativa con la especialidad de Ortodoncia con independencia de la edad y género del odontólogo. En relación a la segunda situación clínica no se ha encontrado ninguna diferencia estadísticamente significativa con respecto a edad, género y especialidad del odontólogo

MicroRNA-21 Expression as a Prognostic Biomarker in Oral Cancer: Systematic Review and Meta-Analysis

Oral carcinoma represents one of the main carcinomas of the head and neck region, with a 5-year survival rate of less than 50%. Smoking and tobacco use are recognized risk factors. Prognostic survival biomarkers can be a valid tool for assessing a patient’s life expectancy and directing therapy towards specific targets. Among the biomarkers, the alteration of miR-21 expression in tumor tissues is increasingly reported as a valid prognostic biomarker of survival for oral cancer. The purpose of this meta-analysis was, therefore, to investigate and summarize the results in the literature concerning the potential prognostic expression of tissue miR-21 in patients with OSCC. Methods: The systematic review was conducted following the PRISMA guidelines using electronic databases, such as PubMed, Scopus, and the Cochrane Central Register of Controlled Trials, with the use of combinations of keywords, such as miR-21 AND oral cancer, microRNA AND oral cancer, and miR-21. The meta- analysis was performed using the RevMan 5.41 software. Results: At the end of the article-selection process, 10 studies were included in the meta-analysis, and the result for the main outcome was a pooled HR per overall survival (OS) of 1.29 (1.16–1.44) between high and low expression of miR-21. Conclusions: The data in the literature and the results emerging from the systematic review indicate that miR-21 can provide a prognostic indication in oral cancer

From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis

Background and objective: Diabetes mellitus (DM) refers to a group of metabolic disorders characterized by hyperglycemia resulting from impaired secretion or action of insulin. The high levels of glucose in the blood can negatively affect the healing processes through alterations in vascularization, bone remodeling, and with increased susceptibility to infections. Diabetes mellitus is therefore a risk factor not only for many systemic diseases, but also for localized problems such as peri-implantitis. The objective of this systematic review was to identify a clear relationship between peri-implant inflammation indices and glycemic levels, through the investigation of prospective studies that report data on a short-term follow-up period. Our hypothesis was that peri-implant inflammatory indices may already present themselves in a statistically significant way as altered in patients with DM compared to patients without DM. Materials and methods: This review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Results: More than 992 records were identified in the PubMed, Scopus, and Cochrane Central Register of Controlled Trial electronic databases and only seven studies were included in the meta-analysis. The results of the meta-analysis report worse outcomes in patients with DM, even in the short period of six months, for peri-implatitis inflammation indices, such as Marginal bone loss (standardized (Std). mean difference (MD) 12 months 0.81 [0.45, 1.17].82 [0.53, 3.10]), Bleeding on probing (Std. MD 12 months 2.84 [1.34, 4.34].44 [1.41, 5.50]), Probing depth (Std. MD 12 months 1.14 [0.60, 1.68].24 [0.66, 3.83]), and the plaque index (Std. MD 12 months 2.83 [0.09, 5.57]). Conclusion: The literature linking glycaemic control to peri-implant disease is highly heterogeneous due to lack of consistency of the definition of peri-implantitis and its clinical indicators among studies. Therefore, interpretation of finding and relevance to clinical practice should be considered on individual bases. In the era of personalized medicine, the clinician should utilize individualized information from translational researches and analyze all risk factors to provide the patient with evidence-based treatment options

Serum Albumin Is Inversely Associated With Portal Vein Thrombosis in Cirrhosis

We analyzed whether serum albumin is independently associated with portal vein thrombosis (PVT) in liver cirrhosis (LC) and if a biologic plausibility exists. This study was divided into three parts. In part 1 (retrospective analysis), 753 consecutive patients with LC with ultrasound-detected PVT were retrospectively analyzed. In part 2, 112 patients with LC and 56 matched controls were entered in the cross-sectional study. In part 3, 5 patients with cirrhosis were entered in the in vivo study and 4 healthy subjects (HSs) were entered in the in vitro study to explore if albumin may affect platelet activation by modulating oxidative stress. In the 753 patients with LC, the prevalence of PVT was 16.7%; logistic analysis showed that only age (odds ratio [OR], 1.024; P = 0.012) and serum albumin (OR, -0.422; P = 0.0001) significantly predicted patients with PVT. Analyzing the 112 patients with LC and controls, soluble clusters of differentiation (CD)40-ligand (P = 0.0238), soluble Nox2-derived peptide (sNox2-dp; P < 0.0001), and urinary excretion of isoprostanes (P = 0.0078) were higher in patients with LC. In LC, albumin was correlated with sCD4OL (Spearman's rank correlation coefficient [r(s)], -0.33; P < 0.001), sNox2-dp (r(s), -0.57; P < 0.0001), and urinary excretion of isoprostanes (r(s), -0.48; P < 0.0001) levels. The in vivo study showed a progressive decrease in platelet aggregation, sNox2-dp, and urinary 8-iso prostaglandin F2 alpha-III formation 2 hours and 3 days after albumin infusion. Finally, platelet aggregation, sNox2-dp, and isoprostane formation significantly decreased in platelets from HSs incubated with scalar concentrations of albumin. Conclusion: Low serum albumin in LC is associated with PVT, suggesting that albumin could be a modulator of the hemostatic system through interference with mechanisms regulating platelet activation

Measuring the social impact of research in Paediatric Dentistry: An Altmetric study

Background: Traditional metrics have been extensively used to evaluate the scientific performance. Despite being widespread accepted, citation-based metrics are not able to describe the social impact of research. A diverse metric, Altmetric, was proposed to overcome those limitations. Aim: This study aims to analyse the social impact of research in the field of paediatric dentistry and to assess if a correlation exists between the JCR citations, the AAS score, and the recently released Dimensions citation count. Design: A bibliometric study was conducted on the four journals related to Paediatric Dentistry listed in the JCR from 2014 to 2017. Descriptive statistics was used to describe the articles and the journals. Pearson's correlation analysis was used to explore the relationship among JCR citations, AAS, and Dimensions. Results: The percentage of articles with an AAS presents a huge variability and was significantly higher in the International Journal of Paediatric Dentistry. In our sample, the correlation between the JCR citation count and the AAS was poor in the years 2014, 2015, and 2016 and low in 2017. The correlation between JCR citation and Dimensions citation count was strong. Conclusions: The social impact of research in paediatric dentistry can be increased. Dimensions could be an alternative to the JCR. Both the editors and the researcher should change their vision and facilitate the access to research information to scholar and non-scholar audiences.Sin financiación3.455 JCR (2020) Q1, 22/129 Pediatrics1.183 SJR (2020) Q1, 11/141 Dentistry (miscellaneous)No data IDR 2020UE

Space Regaining Made Easy: The Case of a Severely Infraoccluded Primary Molar

Infraocclusion of deciduous molars is a quite common but challenging clinical situation that a paediatric dentist has to face in his everyday practice. This anomaly can lead to space loss, eruption disturbances of the permanent successor, and deformation of the occlusal plane. A case of a severely infraoccluded primary molar is presented. The treatment was carried out using a compressed NiTi wire applied only to the adjacent teeth. In three months, the space was recovered, and the infraoccluded temporary molar was extracted. After one year, the permanent successor erupted without any complication. The technique presented can be considered minimally invasive, and it involves cost- and time-efficient mechanics.Sin financiaciónNo data JCR 20190.242 SJR (2019) Q3, 93/148 Dentistry (miscellaneous)No data IDR 2019UE

Uncovering and autonomous eruption of palatally impacted canines

Background: The palatal impaction of maxillary canine is a quite common yet challenging clinical condition that orthodontists have to face in the everyday practice. The purpose of this report is to describe and discuss a case involving the uncovering of an upper canine and it subsequent spontaneous eruption. Case report: The diagnostic and therapeutic protocol of a case with a palatally impacted canine is presented. The upper right canine was uncovered with an open surgical approach. Removal of the attached gingiva and bone covering the crown enhanced the tooth spontaneous eruption, while the first levelling and aligning phase of the treatment was performed. This approach results in a shorter overall treatment time. This protocol produced an aesthetic, healthy and functional result, which was stable at the two-year post-treatment follow-up.Sin financiación0.870 JCR (2018) Q4, 82/91 Dentistry, Oral Surgery & Medicine0.631 SJR (2018) Q2, 38/148 Dentistry (miscellaneous)No data IDR 2018UE

Publishing challenges in the new decade - Publish (on social media)… or perish?

Sin financiación2.231 JCR (2020) Q3, 57/92 Dentristry, Oral Surgery & Medicine0.698 SJR (2020) Q2, 37/92 Dentistry Dentistry (miscellaneous)No data IDR 2020UE

The online attention to orthodontic research: an Altmetric analysis of the orthodontic journals indexed in the journal citation reports from 2014 to 2018

Background: To describe the impact of research, beyond the limits of the academic environment, Altmetric, a new social and traditional media metric was proposed. The aims of this study were to analyze the online activity related to orthodontic research via Altmetric and to assess if a correlation exists among citations, Mendeley reader count, and the AAS (Altmetric Attention Score). Method: The Dimensions App was searched for articles published in the orthodontic journals listed in the Journal Citation Reports (JCR) throughout the years 2014 to 2018. The articles with a positive AAS were collected and screened for data related to publication and authorship. The articles with an AAS higher than 5 were screened for research topic and study design. Citation counts were harvested from Web of Science (WOS) and Scopus. Results: The best performing journals were Progress in Orthodontics and the European Journal of Orthodontics with a mean AAS per published item of 1.455 and 1.351, respectively and the most prevalent sources were Tweets and Facebook mentions. The most prevalent topic was Oral Health-Related Quality of Life (OHRQOL) and the study design was systematic reviews. The correlation between the AAS and the citations in both WOS and Scopus was poor (r = 0.1463 and r = 0.1508, p < .05). The correlation between citations count and Mendeley reader (r = 0.6879 and r = 0.697, p < .05) was moderate. Conclusions: Few journals displayed a high level of web activity. Journals and editors should enhance online dissemination of the scientific outputs. The authors should report the impact of the findings to the general public in a convenient way to facilitate online dissemination but to avoid an opportunistic use of the research outputs. Despite the lack of correlation, a combination of the citation count and the AAS can give a more comprehensive assessment of research impact.Sin financiación2.750 JCR (2020) Q2, 37/92 Dentistry, Oral Surgery & Medicine0.949 SJR (2020) Q1, 4/22 OrthodonticsNo data IDR 2020UE

Invisalign treatment from the patient perspective: A Twitter content analyses

Background: Understanding patient perspective is a key factor in improving treatment satisfaction. The aim of the present study is to qualitatively describe the content of Twitter posts related to the treatment with Invisalign in order to get a better understanding of patient experience. Material and Methods: Tweets were prospectively collected during a period of four weeks from public available posts on Twitter using Awario™ a bespoke social media monitoring tool. After applying the pertinent inclusion and exclusion criteria the selected posts were analysed by three investigators using thematic analysis. Specific themes and subthemes were developed. Results: A total of 1564 tweets were analysed; three mayor themes were identified: Pre-treatment related, Treatment related and Patient/clinician relationship. Pre-treatment posts were mainly positive and underlined patients’ expectations, while in the treatment phase an almost equal number of positive and negative posts were found. The positive post were about the satisfaction with treatment and the improvement of self-esteem. The negative ones were related to pain, compliance, the impact on diet and pronunciation. Conclusions: The present study provides a better understanding of patients’ experience during clear aligners treatment. Increasing the awareness of the clinicians can improve their ability to face problems related to the orthodontic treatment and to provide to their patients better professional advices and counselling.Comprender la expectativa del paciente es un factor clave para mejorar la satisfacción con el tratamiento. El objetivo del presente estudio es describir cualitativamente el contenido de las publicaciones de Twitter relacionadas con el tratamiento con Invisalign para comprender mejor la experiencia del paciente. Material y métodos: los tweets se recopilaron prospectivamente durante un período de cuatro semanas a partir de publicaciones disponibles al público en Twitter utilizando Awario TM, una herramienta de monitoreo de redes sociales a medida. Después de aplicar los criterios de inclusión y exclusión pertinentes, las publicaciones seleccionadas fueron analizadas por tres investigadores mediante análisis temático. Se desarrollaron temas y sub-temas específicos. Resultados: Se analizaron un total de 1564 tuits; Se identificaron tres temas principales: relacionados con el pre-tratamiento, relacionados con el tratamiento y la relación paciente/médico. Las publicaciones previas al tratamiento fueron principalmente positivas y subrayaron las expectativas de los pacientes, mientras que en la fase de tratamiento se encontró un número casi igual de publicaciones positivas y negativas. Los post positivos fueron sobre la satisfacción con el trato y la mejora de la autoestima. Los negativos estaban relacionados con el dolor, el cumplimiento, el impacto en la dieta y la pronunciación. Conclusiones: El presente estudio proporciona una mejor comprensión de la experiencia de los pacientes durante el tratamiento con alineadores transparentes. Aumentar la conciencia de los clínicos puede mejorar su capacidad para enfrentar los problemas relacionados con el tratamiento de ortodoncia y brindar a sus pacientes mejores consejos y asesoramiento profesional.Sin financiación0.400 JCR (2020) Q2, 63/141 Medicine (Miscellaneous)0.481 SJR (2020) Q2, 63/141 Dentistry (miscellaneous)No data IDR (2020)UE