A indústria de calçados de Nova Serrana (MG)

On the basis of previous statistical work with data and information from RAIS - Relação Anual de Informações Sociais, characterizing the Nova Serrana shoe industry as a local production system, and the results of a field research work with visits and interviews in local firms and institutions, this paper studies the Nova Serrana local production system as a whole as well as its firms and supporting institutions. The objective is to bring empirical evidence to guide public policy and private actions with a view to upgrade the local system in two spheres: (1) productive and technological, and (2) institutional and organizational. With this purpose in mind, this paper first characterizes and describes the local system in terms of location, adjoining influenced areas, logistics, population and number of jobs, history and evolution, production structure, supporting institutions, and social, cultural and political contexts. Next, the paper characterizes local firms in terms of size, product development, trading system, cooperation between rival firms, interactions with suppliers, sources of information for product development and on market trends and production technologies, practices and policies with regard to quality, financing, and other aspects. Finally, the paper summarizes the most relevant issues for policy measures and private actions by local firms and institutions

INOVAÇÃO E CONHECIMENTO: INDICADORES REGIONALIZADOS E APLICAÇÃO A SÃO PAULO

This paper develops multiple indicators to map the geographical distribution of knowledge and scientific and technological capabilities as proxies of the geographical distribution of S,T&I activities, and applies such indicators to data and information from the state of São Paulo. The overall view of the geographical distribution of S,T&I activities in the state is complemented by the analysis of the same activities in the perspective of a local production and innovation system: the case of information and communication technologies in the microrregion of Campinas. The results show a pattern for the regional distributions of S,T&I activities along the main highways of the state, around metropolitan areas such as São Paulo and Campinas, and in regions where educational, science and technology and R&D institutions are strongly concentrated. Firms tend to agglomerate in these areas and regions, forming local production and innovation systems. The paper produces evidence on the adherence of the geographical distribution of those systems to the geographical distribution of S,T&I activities as shown by the indicators. This confirms the empirical findings of the literature about the relationship between geography and innovation.

Coeficientes de Gini locacionais - GL: aplicação à indústria de calçados do Estado de São Paulo [Locational Gini coefficients - LG: application to the shoe industry in the state of São Paulo]

This paper suggests a specific methodology to geographically locate and delimit local production systems, with an application to the leather and shoe industry in the state of São Paulo. The methodology consists on the elaboration of locational Gini coefficients (GL) for four-digit industries at municipal or micro region level from data in RAIS/MTE and PIA/IBGE. These GL coefficients indicate the industrial branches which are spatially concentrated. For the latter, location quotients (QL) by microregions in the state are used in order to identify local production systems within these industries. The QL data - combined with data on the share of the microregion in question in total industry employment and number of industrial plants - unequivocally show that there are three main local production systems in the leather and shoe industry in the state of São Paulo: Franca, Birigui, and Jaú. Based on a field research work, these three local systems are briefly characterized in regard to their location, territorial extension, production structure and integration, local institutions, and forms of interfirm cooperation.Locational Gini coefficients, locational quotients, local production systems, spatial concentration

New insights into the outflows from R Aquarii

R Aquarii is a symbiotic binary surrounded by a large and complex nebula with a prominent curved jet. It is one of the closest known symbiotic systems, and therefore offers a unique opportunity to study the central regions of these systems and the formation and evolution of astrophysical jets. We studied the evolution of the central jet and outer nebula of R Aqr taking advantage of a long term monitoring campaign of optical imaging, as well as of high-resolution integral field spectroscopy. Narrow-band images acquired over a period of more than 21 years are compared in order to study the expansion and evolution of all components of the R Aqr nebula. The magnification method is used to derive the kinematic ages of the features that appear to expand radially. Integral field spectroscopy of the OIII 5007A emission is used to study the velocity structure of the central regions of the jet. New extended features, further out than the previously known hourglass nebula, are detected. The kinematic distance to R Aqr is calculated to be 178 pc using the expansion of the large hourglass nebula. This nebula of R Aqr is found to be roughly 650 years old, while the inner regions have ages ranging from 125 to 290 years. The outer nebula is found to be well described by a ballistic expansion, while for most components of the jet strong deviations from such behaviour are found. We find that the Northern jet is mostly red-shifted while its Southern part is blue-shifted, apparently at odds with findings from previous studies but almost certainly a consequence of the complex nature of the jet and variations in ionisation and illumination between observations.Comment: 13 pages, 8 figures, accepted for publication in A&

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

Malaria is a global health concern and research efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To guide immunogen design, we seek a comprehensive understanding of the protective humoral response against Plasmodium falciparum circumsporozoite protein (PfCSP). In contrast to the well-studied responses to the repeat region and the C-terminus, the antibody response against the N-terminal domain of PfCSP (N-CSP) remains obscure. Here, we characterized the molecular recognition and functional efficacy of the N-CSP-specific monoclonal antibody 5D5. The crystal structure at 1.85 Åresolution revealed that 5D5 binds an α-helical epitope in N-CSP with high affinity through extensive shape and charge complementarity, and the unusual utilization of an N-linked glycan. Nevertheless, functional studies indicated low 5D5 binding to live Pf sporozoites, and lack of sporozoite inhibition in vitro and in mosquitoes. Overall, our data on low recognition and inhibition of sporozoites do not support the inclusion of the 5D5 epitope into the next generation of CSP-based vaccines.Summary Statement The Plasmodium falciparum sporozoite surface protein, PfCSP, is an attractive vaccine target, but the antibody response against the CSP N-terminal domain has remained understudied. Here, to guide immunogen design, Thai et al. provide insights into the binding motif and functional efficacy of the N-terminal domain-specific monoclonal antibody, 5D5

Ultraviolet-Optical observations of the Seyfert 2 Galaxies NGC 7130, NGC 5135 and IC 3639: Implications for the Starburst-AGN Connection

We present and discuss HST (WFPC2 and FOC) images and UV GHRS spectra plus ground-based near UV through to near IR spectra of three Seyfert 2 nuclei (NGC 7130, NGC 5135 and IC 3639). These galaxies, together to Mrk 477, were selected from a bigger sample that comprises the 20 brightest Seyfert 2 nuclei, with the goal to study the origin of the UV-optical-near IR featureless continuum in Seyfert 2 nuclei. These four galaxies have bolometric luminosities, as computed with the four IRAS bands, of 10^11 Lsol. They are close enough to be resolved with HST the nuclear zone. This makes these Seyfert 2 galaxies benchmarks to study the Starburst-AGN connection in more distant galaxies. The data provide direct evidence of the existence of a central nuclear starburst that dominates the UV light, and that seem to be responsible for the origin of the so called featureless continuum. These starbursts are dusty and compact. They have sizes (from less than 100 pc to a few hundred pc) much smaller and closer to the nucleus than that seen in the prototype Seyfert 2 galaxy NGC 1068. The bolometric luminosity of these starbursts is similar to the estimated bolometric luminosities of their obscured Seyfert 1 nuclei, and thus they contribute in the same amount to the overall energetics of these galaxies.Comment: to be published in ApJ 505, September issue. The figures are in a tar files at: http://www.iaa.es/~rosa/Seyfert

Structure of the interstellar medium around Cas A

We present a three-year series of observations at 24 microns with the Spitzer Space Telescope of the interstellar material in a 200 x 200 arcmin square area centered on Cassiopeia A. Interstellar dust heated by the outward light pulse from the supernova explosion emits in the form of compact, moving features. Their sequential outward movements allow us to study the complicated three-dimensional structure of the interstellar medium (ISM) behind and near Cassiopeia A. The ISM consists of sheets and filaments, with many structures on a scale of a parsec or less. The spatial power spectrum of the ISM appears to be similar to that of fractals with a spectral index of 3.5. The filling factor for the small structures above the spatial wavenumber k ~ 0.5 cycles/pc is only ~ 0.4%.Comment: 29 pages including 10 figures; accepted by The Astrophysical Journa

Analysis of a spatial Lotka-Volterra model with a finite range predator-prey interaction

We perform an analysis of a recent spatial version of the classical Lotka-Volterra model, where a finite scale controls individuals' interaction. We study the behavior of the predator-prey dynamics in physical spaces higher than one, showing how spatial patterns can emerge for some values of the interaction range and of the diffusion parameter.Comment: 7 pages, 7 figure