5,931 research outputs found
The introduction of modern physics: overcoming a deformed vision of science
In this paper, we try to show initially that modern physics is usually introduced in high school curricula without reference to the difficulties of classical physics, simply juxtaposing the two paradigms or even mixing them up. As a result, serious misconceptions arise. We then present another way of introducing modern physics, based on a contructivist view of science learning, and give some results obtained with the new materials
Bilateral Internuclear Ophthalmoplegia in a Patient with Devic's Neuromyelitis Optica
An unusual presentation of Devic's neuromyelitis optica (NMO) disease associated with bilateral internuclear ophthalmoplegia (INO) is described. A 32-year-old pregnant patient was diagnosed with NMO. First symptoms were headache and sudden visual loss in her right eye (RE). Eighteen months ago, she reported other neurologic symptoms such as paresthesia. Based on her visual field, fundoscopy and Ishihara test, she was diagnosed with retrobulbar neuritis of the RE. After delivery, new neurologic symptoms resembling transverse myelitis appeared. She was treated with methylprednisolone and plasmapheresis, which improved her visual acuity; however, a sudden bilateral INO appeared, with adduction defect and nystagmus with abduction in both eyes. No improvement was obtained after treatment with azathioprine and rituximab. Paresis of the legs and the right arm persisted, but double vision and OIN gradually disappeared. At the end, the patient had a residual exophoria in the RE and nystagmus with abduction in the left eye. Prevalence of NMO is lower than one case per one million inhabitants, and it is not likely to affect the encephalic trunk; furthermore, bilateral INO in NMO is rare. Two major criteria and at least two of the three minor ones are required to confirm a NMO diagnosis, and our patient fulfilled these diagnosis criteria
Inflation-Produced Magnetic Fields in Nonlinear Electrodynamics
We study the generation of primeval magnetic fields during inflation era in
nonlinear theories of electrodynamics. Although the intensity of the produced
fields strongly depends on characteristics of inflation and on the form of
electromagnetic Lagrangian, our results do not exclude the possibility that
these fields could be astrophysically interesting.Comment: 6 page
SWI/SNF regulates a transcriptional programme that induces senescence to prevent liver cancer
Oncogene-induced senescence (OIS) is a potent tumour suppressor mechanism. To identify senescence regulators relevant to cancer, we screened an shRNA library targeting genes deleted in hepatocellular carcinoma (HCC). Here, we describe how knockdown of the SWI/SNF component ARID1B prevents OIS and cooperates with RAS to induce liver tumours. ARID1B controls p16INK4a and p21CIP1a transcription but also regulates DNA damage, oxidative stress and p53 induction, suggesting that SWI/SNF uses additional mechanisms to regulate senescence. To systematically identify SWI/SNF targets regulating senescence, we carried out a focused shRNA screen. We discovered several new senescence regulators including ENTPD7, an enzyme that hydrolyses nucleotides. ENTPD7 affects oxidative stress, DNA damage and senescence. Importantly, expression of ENTPD7 or inhibition of nucleotide synthesis in ARID1B-depleted cells results in re-establishment of senescence. Our results identify novel mechanisms by which epigenetic regulators can affect tumor progression and suggest that pro-senescence therapies could be employed against SWI/SNF-mutated cancers
Restoring the sting to metric preheating
The relative growth of field and metric perturbations during preheating is
sensitive to initial conditions set in the preceding inflationary phase. Recent
work suggests this may protect super-Hubble metric perturbations from resonant
amplification during preheating. We show that this possibility is fragile and
sensitive to the specific form of the interactions between the inflaton and
other fields. The suppression is naturally absent in two classes of preheating
in which either (1) the vacua of the non-inflaton fields during inflation are
deformed away from the origin, or (2) the effective masses of non-inflaton
fields during inflation are small but during preheating are large. Unlike the
simple toy model of a coupling, most realistic particle
physics models contain these other features. Moreover, they generically lead to
both adiabatic and isocurvature modes and non-Gaussian scars on super-Hubble
scales. Large-scale coherent magnetic fields may also appear naturally.Comment: 6 pages, 3 ps figures, RevTex, revised discussion of backreaction and
new figure. To appear Phys. Rev. D (Rapid Communication
Ionized and neutral gas in the peculiar star/cluster complex in NGC 6946
The characteristics of ionized and HI gas in the peculiar star/cluster
complex in NGC 6946, obtained with the 6-m telescope (BTA) SAO RAS, the Gemini
North telescope, and the Westerbork Synthesis Radio Telescope (WSRT), are
presented. The complex is unusual as hosting a super star cluster, the most
massive known in an apparently non-interacting giant galaxy. It contains a
number of smaller clusters and is bordered by a sharp C-shaped rim. We found
that the complex is additionally unusual in having peculiar gas kinematics. The
velocity field of the ionized gas reveals a deep oval minimum, ~300 pc in size,
centered 7" east of the supercluster. The Vr of the ionized gas in the dip
center is 100 km/s lower than in its surroundings, and emission lines within
the dip appear to be shock excited. This dip is near the center of an HI hole
and a semi-ring of HII regions. The HI (and less certainly, HII) velocity
fields reveal expansion, with the velocity reaching ~30 km/s at a distance
about 300 pc from the center of expansion, which is near the deep minimum
position. The super star cluster is at the western rim of the minimum. The
sharp western rim of the whole complex is plausibly a manifestation of a
regular dust arc along the complex edge. Different hypotheses about the complex
and the Vr depression origins are discussed, including a HVC/dark mini-halo
impact, a BCD galaxy merging, and a gas outflow due to release of energy from
the supercluster stars.Comment: MN RAS, accepte
Remote sensing detection of nutrient uptake in vineyards using narrow-band hyperspectral imagery
This manuscript delves further into the assessment of narrow-band vegetation indices derived from hyperspectral imagery acquired at 1 m spatial resolution with the Compact Airborne Spectrographic Imager (CASI). Narrow-band indices proposed in this study were assessed as indicators of biochemical and structural parameters in Vitis vinifera L., observing their relationships with foliar variables such as N, P, K, Ca, Fe, Mg and chlorophyll a+b concentration (Ca+b). Hyperspectral indices were assessed to study their capability for vegetation condition monitoring as a function of fertilization treatments applied (basically extracts of Ascophyllum nodosum seaweed and chelates), showing associations with field variables. Narrow-band vegetation indices displayed sensitivity to vineyard growth and condition as a function of seaweed fertilization and other supplementary mineral correctors, such as chelates. This work shows the interest of using new narrow-band hyperspectral remote sensing indices for vineyard monitoring due to their potential to indicate physiological condition.
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