707 research outputs found
The initial-final mass relationship of white dwarfs in common proper motion pairs
A promising approach to decrease the uncertainties in the initial-final mass relationship, which is still poorly constrained, is to study white dwarfs for which external constraints are available, for instance, white dwarfs in common proper motion pairs (CPMPs). Important information of the white dwarf can be inferred from the study of the companion, since they were born at the same time and with the same initial chemical composition. In this contribution, we report new results obtained from spectroscopic observations of both members of several CPMPs composed of a F, G or K type star and a DA white dwarf
Propuesta innovadora en el marco de la formación del profesorado para la enseñanza secundaria en la especialidad biologia geologia
Strategies to train students in cooperative work through leadership are developed in the Máster de Formación del Profesorado. Aims are to motivate learning within a working team with a leader and leader assistant. The leader will encourage team work, accept responsibilities and organize commands properly by planning the study personally and collectively. The leader assistant's should execute jobs commanded by the leader. The teacher will never be its main source of information
Lowering the background level and the energy threshold of Micromegas x-ray detectors for axion searches
Axion helioscopes search for solar axions by their conversion in x-rays in
the presence of high magnetic fields. The use of low background x-ray detectors
is an essential component contributing to the sensitivity of these searches. In
this work, we review the recent advances on Micromegas detectors used in the
CERN Axion Solar Telescope (CAST) and proposed for the future International
Axion Observatory (IAXO). The actual setup in CAST has achieved background
levels below 10 keV cm s, a factor 100 lower than
the first generation of Micromegas detectors. This reduction is based on active
and passive shielding techniques, the selection of radiopure materials, offline
discrimination techniques and the high granularity of the readout. We describe
in detail the background model of the detector, based on its operation at CAST
site and at the Canfranc Underground Laboratory (LSC), as well as on Geant4
simulations. The best levels currently achieved at LSC are low than 10
keV cm s and show good prospects for the application of
this technology in IAXO. Finally, we present some ideas and results for
reducing the energy threshold of these detectors below 1 keV, using
high-transparent windows, autotrigger electronics and studying the cluster
shape at different energies. As a high flux of axion-like-particles is expected
in this energy range, a sub-keV threshold detector could enlarge the physics
case of axion helioscopes.Comment: Proceedings of 3rd International Conference on Technology and
Instrumentation in Particle Physics (TIPP 2014
TMT-Based Proteomic Analysis of Human Spermatozoa from Unexplained Recurrent Miscarriage Patients before and after Oral Antioxidant Treatment
Recently, sperm quality and the presence of double-stranded breaks (DSB) has been pointed out as a possible cause of recurrent miscarriage, and the use of antioxidants has expanded as a treatment for male infertility. The aim of the present study was to analyze the proteomic effects of antioxidants on sperm from RM patients with high incidence of DSB. Proteomic analysis was performed using a tandem mass tag labeling technique, and subsequently compared with the PANTHER database for DEPs, and the STRING database for protein-protein interactions (PPI). Differentially expressed proteins (DEPs) both before and after antioxidant oral treatment were identified. PPI involving DEPs clustered into networks related to cell metabolism, cytoskeleton, and DNA damage. Results show that the sperm proteomic profiles before and after antioxidant treatment do not significantly differ from each other. However, some DEPs found after the antioxidant treatment shifted towards a DEPs profile typical of fertile donors. This indirect measurement suggests an improvement caused by antioxidants on the expression of several proteins. Among them were proteins involved in sperm DNA remodeling (LMO7, MMP28, BNC2, H2B, and PRDM2). The results presented here represent the first approach in the analysis and repair of the proteomic change caused by antioxidants in recurrent miscarriage patients, elucidating biomarkers that may be useful for the diagnosis and further sperm selection in this type of patient. Further studies should be conducted to validate the usefulness of these biomarkers in larger study groups
A Micromegas-based low-background x-ray detector coupled to a slumped-glass telescope for axion research
We report on the design, construction and operation of a low background x-ray
detection line composed of a shielded Micromegas (micromesh gaseous structure)
detector of the microbulk technique. The detector is made from radiopure
materials and is placed at the focal point of a ~5 cm diameter, 1.3 m
focal-length, cone-approximation Wolter I x-ray telescope (XRT) comprised of
thermally-formed (or "slumped") glass substrates deposited with multilayer
coatings. The system has been conceived as a technological pathfinder for the
future International Axion Observatory (IAXO), as it combines two of the
techniques (optic and detector) proposed in the conceptual design of the
project. It is innovative for two reasons: it is the first time an x-ray optic
has been designed and fabricated specifically for axion research, and the first
time a Micromegas detector has been operated with an x-ray optic. The line has
been installed at one end of the CERN Axion Solar Telescope (CAST) magnet and
is currently looking for solar axions. The combination of the XRT and
Micromegas detector provides the best signal-to-noise ratio obtained so far by
any detection system of the CAST experiment with a background rate of
5.410counts per hour in the energy region-of-interest and
signal spot area.Comment: 21 pages, 16 figure
Towards a new generation axion helioscope
We study the feasibility of a new generation axion helioscope, the most
ambitious and promising detector of solar axions to date. We show that large
improvements in magnetic field volume, x-ray focusing optics and detector
backgrounds are possible beyond those achieved in the CERN Axion Solar
Telescope (CAST). For hadronic models, a sensitivity to the axion-photon
coupling of \gagamma\gtrsim {\rm few} \times 10^{-12} GeV is
conceivable, 1--1.5 orders of magnitude beyond the CAST sensitivity. If axions
also couple to electrons, the Sun produces a larger flux for the same value of
the Peccei-Quinn scale, allowing one to probe a broader class of models. Except
for the axion dark matter searches, this experiment will be the most sensitive
axion search ever, reaching or surpassing the stringent bounds from SN1987A and
possibly testing the axion interpretation of anomalous white-dwarf cooling that
predicts of a few meV. Beyond axions, this new instrument will probe
entirely unexplored ranges of parameters for a large variety of axion-like
particles (ALPs) and other novel excitations at the low-energy frontier of
elementary particle physics.Comment: 37 pages, 11 figures, accepted for publication in JCA
Seminal Microbiota of Idiopathic Infertile Patients and Its Relationship With Sperm DNA Integrity
The development of new biomarkers for human male infertility is crucial to improve the diagnosis and the prognosis of this disease. Recently, seminal microbiota was shown to be related to sperm quality parameters, suggesting an effect in human fertility and postulating it as a biomarker candidate. However, its relationship to sperm DNA integrity has not been studied yet. The aim of the present study is to characterize the seminal microbiota of a western Mediterranean population and to evaluate its relationship to sperm chromatin integrity parameters, and oxidative stress. For that purpose, 14 samples from sperm donors and 42 samples from infertile idiopathic patients were obtained and were analyzed to assess the composition of the microbiota through full-length 16S rRNA gene sequencing (Illumina MiSeq platform). Microbial diversity and relative abundances were compared to classic sperm quality parameters (macroscopic semen parameters, motility, morphology and concentration), chromatin integrity (global DNA damage, double-stranded DNA breaks and DNA protamination status) and oxidative stress levels (oxidation-reduction potential). The seminal microbiota observed of these samples belonged to the phyla Firmicutes, Proteobacteria, Actinobacteria and Bacteroidetes. The most abundant genera were Finegoldia, Peptoniphilus, Anaerococcus, Campylobacter, Streptococcus, Staphylococcus, Moraxella, Prevotella, Ezakiella, Corynebacterium and Lactobacillus. To our knowledge, this is the first detection of Ezakiella genus in seminal samples. Two clusters of microbial profiles were built based on a clustering analysis, and specific genera were found with different frequencies in relation to seminal quality defects. The abundances of several bacteria negatively correlate with the sperm global DNA fragmentation, most notably Moraxella, Brevundimonas and Flavobacterium. The latter two were also associated with higher sperm motility and Brevundimonas additionally with lower oxidative-reduction potential. Actinomycetaceae, Ralstonia and Paenibacillus correlated with reduced chromatin protamination status and increased double-stranded DNA fragmentation. These effects on DNA integrity coincide in many cases with the metabolism or enzymatic activities of these genera. Significant differences between fertile and infertile men were found in the relative presence of the Propionibacteriaceae family and the Cutibacterium, Rhodopseudomonas and Oligotropha genera, which supports its possible involvement in male fertility. Our findings sustain the hypothesis that the seminal microbiome has an effect on male fertility
A Yoga and Compassion Meditation Program Reduces Stress in Familial Caregivers of Alzheimer's Disease Patients
Familial caregivers of patients with Alzheimer's disease exhibit reduced quality of life and increased stress levels. the aim of this study was to investigate the effects of an 8-week yoga and compassion meditation program on the perceived stress, anxiety, depression, and salivary cortisol levels in familial caregivers. A total of 46 volunteers were randomly assigned to participate in a stress-reduction program for a 2-month period (yoga and compassion meditation program-YCMP group) (n = 25) or an untreated group for the same period of time (control group) (n = 21). the levels of stress, anxiety, depression, and morning salivary cortisol of the participants were measured before and after intervention. the groups were initially homogeneous; however, after intervention, the groups diverged significantly. the YCMP group exhibited a reduction of the stress (P < 0.05), anxiety (P < 0.000001), and depression (P < 0.00001) levels, as well as a reduction in the concentration of salivary cortisol (P < 0.05). Our study suggests that an 8-week yoga and compassion meditation program may offer an effective intervention for reducing perceived stress, anxiety, depression, and salivary cortisol in familial caregivers.Associacao Fundo de Incentivo a Pesquisa-AFIPUniversidade Federal de São Paulo UNIFESP, Dept Psychobiol, BR-04024002 São Paulo, BrazilInst Appana Mind Desenvolvimento Humano, Departiment Res, BR-05436020 São Paulo, BrazilHosp Israelita Albert Einstein, Inst Cerebro, BR-05601901 São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Div Endocrinol, Dept Med, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Psychobiol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Div Endocrinol, Dept Med, BR-04023062 São Paulo, BrazilWeb of Scienc
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