Application of Computer Simulation Modeling to Evaluate Business Continuity Plans

Business continuity plans (BCP) help organizations plan for and withstand the occurrence of unexpected events that interrupt the normal operation of business. Managers typically develop several alternate plans to minimize the business impact of unexpected events. The problem for decision makers is that comparative evaluation of BCP is typically done using subjective judgments. This research uses a case study approach focusing on a single organization and a single business continuity application to propose the use of computer simulation as a tool for managers to identify and evaluate different BCP prior to committing resources. In the context of an insurance firm, a specific plan was evaluated using simulation methods. A simulation model was used to model the operational aspects of the call center in an insurance company. After the model was validated, it was used to answer questions about what-if scenarios. Results suggest that scenario analysis using simulated model enables managers to ask useful questions that can help evaluate the plan. Managers at the insurance company used the simulation model to determine the level of service required and evaluate business continuity strategies to achieve it

Towards a TDD maturity model through an anti-patterns framework

Agile software development has been adopted in the industry to quickly react to business change. Since its inception both academia and industry debate the different shades that agile processes and technical practices play in the day-to-day of students and professional developers. Efforts have been made to understand the pros and cons of the Test Driven Development (TDD) practice to develop software as part of a professional environment. Despite the effort of practitioners to list the TDD anti-patterns that unveil undesired effects in the code when practicing TDD, work is needed to understand the causes that lead to that. In that sense, this paper proposes a research project that explores the TDD anti-patterns context and what leads practitioners to face them in the software development context. As a result, we expect to offer a TDD maturity framework to help practitioners in the process of writing code guided by tests and prevent the addition of anti-pattern

A comparative analysis between two statistical deviation–based consensus measures in group decision making problems

The mean absolute deviation and the standard deviation, two statistical measures commonly used in quantifying variability, may become an interesting tool when defining consensus measures. Two consensus indexes which obtain the level of consensus in some problems of Group Decision Making are introduced in this paper by expanding the aforementioned statistical concepts. A comparative analysis reveals that the levels of consensus derived from these indexes are close to those obtained employing distance functions when a fuzzy preference relations frame is considered, so they turn out to be a useful tool in this context. In addition, these indexes are different from each other and with the distance functions considered. Thus, they are applicable tools in the calculation of consensus in our context and are different from those commonly used

Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia

Perinatal asphyxia (PA) remains as one of the most important causes of short-term mortality, psychiatric and neurological disorders in children, without an effective treatment. In previous studies we have observed that the expression of different neurodegenerative markers increases in CA1 hippocampal area of 4-months-old male rats born by cesarean section and exposed for 19 min to PA. We have also shown that a late treatment with 17β estradiol (daily dose of 250 μg/kg for 3 days) was able to revert the brain alterations observed in those animals. Based on these previous results, the main aim of the present study was to explore the mechanism by which the estrogenic treatment is involved in the reversion of the chronic neurodegenerative conditions induced by PA. We demonstrated that estradiol treatment of adult PA exposed animals induced an increase in estrogen receptor (ER) a and insulin-like growth factor receptor (IGF-1R) protein levels, an activation of the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 beta/β-catenin signaling pathway and an increase in Bcl-2/Bax ratio in the hippocampus in comparison to PA exposed animals treated with vehicle. Taking together, our data suggest that the interaction between ERa and IGF-IR, with the subsequent downstream activation, underlies the beneficial effects of estradiol observed in late treatment of PA.Fil: Saraceno, Gustavo Ezequiel. Universite de Bordeaux; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Bellini, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Garcia Segura, Luis Miguel. Consejo Superior de Investigaciones Científicas; España. Instituto de Salud Carlos III; EspañaFil: Capani, Francisco. Universidad Autónoma de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentin