Autologous Transplantation of Adrenal Medulla Into the Caudate Nucleus: A Four Year Follow Up Study

The objective of this study was to determine whether the associated morbidity and mortality of adrenal medulla autologous transplantation into the striatum (open transcortical procedure) justifies this as a safe and effective treatment for Parkinson's Disease (PD)

Search For Spin-lattice Coupling Mediated By Itinerant Electrons: Synchrotron X-ray Diffraction And Raman Scattering From Gd Al3

The coupling among the spin degree of freedom and the atomic displacements in intermetallic Gd Al3 was investigated by means of synchrotron x-ray diffraction and polarized Raman scattering. In this compound, the Gd 4 f7 shell is spherical and the spin-lattice coupling provides a fingerprint of the exchange mechanism and degree of magnetic correlations. X-ray diffraction shows nonresonant symmetry-forbidden charge Bragg peaks below the long-range magnetic ordering temperature TN =18 K, revealing a symmetry-lowering crystal lattice transition associated with Gd displacements, consistent with a Ruderman-Kittel-Kasuya-Yosida mechanism for the magnetic coupling. Raman scattering in fresh broken surfaces shows phonons with conventional frequency behavior, while naturally grown and polished surfaces present frequency anomalies below T* ∼50 K. Such anomalies are possibly due to a modulation of the magnetic energy by the lattice vibrations in a strongly spin-correlated paramagnetic phase. 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Intestinal resection and primary anastomosis as treatment of intussusception due to ileum lipoma: case report and review

Intussusception is an unusual cause of intestinal occlusion in adults, accounting for 5% of cases, and is the result of an underlying pathology in 90% of cases, 60% of which are tumors. The pathogenesis describes the invagination of an intestinal segment into the lumen of an adjacent segment with subsequent alterations in irrigation, risk of necrosis and perforation. Surgical management is indicated in adult patients to restore intestinal transit and to exclude malignancy as the axis of the intussusception. We present the case of a 58-year-old female patient with enteric intussusception at ileum due to lipoma, who underwent bowel resection and manual end-to-end intestinal anastomosis in two planes

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

Malaria is a global health concern and research efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To guide immunogen design, we seek a comprehensive understanding of the protective humoral response against Plasmodium falciparum circumsporozoite protein (PfCSP). In contrast to the well-studied responses to the repeat region and the C-terminus, the antibody response against the N-terminal domain of PfCSP (N-CSP) remains obscure. Here, we characterized the molecular recognition and functional efficacy of the N-CSP-specific monoclonal antibody 5D5. The crystal structure at 1.85 Åresolution revealed that 5D5 binds an α-helical epitope in N-CSP with high affinity through extensive shape and charge complementarity, and the unusual utilization of an N-linked glycan. Nevertheless, functional studies indicated low 5D5 binding to live Pf sporozoites, and lack of sporozoite inhibition in vitro and in mosquitoes. Overall, our data on low recognition and inhibition of sporozoites do not support the inclusion of the 5D5 epitope into the next generation of CSP-based vaccines.Summary Statement The Plasmodium falciparum sporozoite surface protein, PfCSP, is an attractive vaccine target, but the antibody response against the CSP N-terminal domain has remained understudied. Here, to guide immunogen design, Thai et al. provide insights into the binding motif and functional efficacy of the N-terminal domain-specific monoclonal antibody, 5D5

Design, synthesis, and characterization of stapled oligosaccharides

Stapling short peptides to lock specific conformations and thereby obtain superior pharmacological properties is well established. However, similar concepts have not been applied to oligosaccharides. Here, we describe the design, synthesis, and characterization of the first stapled oligosaccharides. Automated assembly of β-(1,6)-glucans equipped with two alkenyl side chains was followed by on-resin Grubbs metathesis for efficient ring closure with a variety of cross-linkers of different sizes. Oligosaccharide stapling increases enzymatic stability and cell penetration, therefore opening new opportunities for the use of glycans in medicinal chemistry

HER2/HER3 regulates lactate secretion and expression of lactate receptor mRNA through the MAP3K4 associated protein GIT1

One of the major features of cancer is Otto Warburg's observation that many tumors have increased extracellular acidification compared to healthy tissues. Since Warburg's observation, the importance of extracellular acidification in cancer is now considered a hallmark of cancer. Human MAP3K4 functions upstream of the p38 and JNK mitogen activated protein kinases (MAPKs). Additionally, MAP3K4 is required for cell migration and extracellular acidification of breast cancer cells in response to HER2/HER3 signaling. Here, we demonstrate that GIT1 interacts with MAP3K4 by immunoprecipitation, while cellular lactate production and the capacity of MCF-7 cells for anchorage independent growth in soft agar were dependent on GIT1. Additionally, we show that activation of HER2/HER3 signaling leads to reduced expression of lactate receptor (GPR81) mRNA and that both, GIT1 and MAP3K4, are necessary for constitutive expression of GPR81 mRNA. Our study suggests that targeting downstream proteins in the HER2/HER3-induced extracellular lactate signaling pathway may be a way to inhibit the Warburg Effect to disrupt tumor growth.NIEHS Training grant [ES007091]; Arizona Science Foundation [CAA 0226-08, ES006694, ES012007, ES04940]Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Chemical composition, physicochemical evaluation and sensory analysis of yogurt added with extract of polyphenolic compounds from Quercus crassifolia oak bark

Introduction: A diet high in calories and saturated fats has been associated with health problems that have been increasing worldwide. Therefore, it is required to increase the number of formulated foods that generate well-being to health. Yogurt is a widely consumed food by all sectors of the population and it can be used as a vehicle to incorporate bioactive compounds. The phenolic compounds present in forest residues, such as those from oak bark, can be used and incorporated into yogurt, to increase its benefits as a functional food. Objective: The objective of this study was to develop a multifunctional yogurt enriched with vegetable oil (2.3% w/w) as a source of omega 6 and 3 and adding nanocapsules (24.5% w/w) of an extract of oak bark from Quercus crassifolia, rich in in phenolic compounds and high antioxidant capacity. Methods: Three yogurt formulations were prepared: F1: yogurt was made with non-fat milk, used as a control, F2: yogurt was prepared with non-fat milk and added with vegetable palm oil, and F3: non-fat yogurt was added with vegetable oil and nanoencapsulated oak bark phenolic extract. The yogurts were characterized in their chemical composition, microbiological analysis, and sensory analysis. Results: The multifunctional product F3 and product F2 presented lactic acid bacteria in concentration of 3.01X106 and 4.73x106, respectively, preserving characteristics of probiotic food. Product F3 presented low levels of syneresis (7.34%) and it was significantly different from the control yogurt (9.01%). The viscosity increased from 150 cP in the control yogurt to 341 cP in F3, due to the increase in the concentrations of solids by nanoencapsulating the phenolic. The wall material used for nanoencapsulation was sodium caseinate and mantodextrin. However, this increase in viscosity did not affect the sensory evaluation of the product. There were no significant differences between the control yogurt and the F2 and F3 products. Conclusion: A yogurt added with vegetable oil and nanoencapsulated oak bark phenolic extract was obtained. It was enhanced by the presence of probiotics, bioactive compounds, and essential fatty acids, and then evaluated and accepted by a sensory panel. Nanoencapsulation is a viable alternative to mask the characteristic astringent taste of phenolic compounds because it was not detected by the panelists

Inguinal plasty and appendectomy as treatment for Amyand's hernia: case report and literature review

Amyand's hernia is described as the presence of the caecal appendix within the hernial sac of an incarcerated inguinal hernia. It was reported as an incidental finding in 1% of cases and with evidence of appendicitis in 0.1% of cases. The approach involves performing appendectomy and inguinal repair in the same surgical time, depending on the clinical scenario and the surgeon's decisions. We presented the case of a 76-year-old male patient with a diagnosis of Amyand's right inguinal hernia diagnosed during trans-operative right inguinal plasty