1,038 research outputs found
On the abundance discrepancy problem in HII regions
The origin of the abundance discrepancy is one of the key problems in the
physics of photoionized nebula. In this work, we analize and discuss data for a
sample of Galactic and extragalactic HII regions where this abundance
discrepancy has been determined. We find that the abundance discrepancy factor
(ADF) is fairly constant and of the order of 2 in all the available sample of
HII regions. This is a rather different behaviour than that observed in
planetary nebulae, where the ADF shows a much wider range of values. We do not
find correlations between the ADF and the O/H, O++/H+ ratios, the ionization
degree, Te(High), Te(Low)/ Te(High), FWHM, and the effective temperature of the
main ionizing stars within the observational uncertainties. These results
indicate that whatever mechanism is producing the abundance discrepancy in HII
regions it does not substantially depend on those nebular parameters. On the
contrary, the ADF seems to be slightly dependent on the excitation energy, a
fact that is consistent with the predictions of the classical temperature
fluctuations paradigm. Finally, we obtain that Te values obtained from OII
recombination lines in HII regions are in agreement with those obtained from
collisionally excited line ratios, a behaviour that is again different from
that observed in planetary nebulae. These similar temperature determinations
are in contradiction with the predictions of the model based on the presence of
chemically inhomogeneous clumps but are consistent with the temperature
fluctuations paradigm. We conclude that all the indications suggest that the
physical mechanism responsible of the abundance discrepancy in HII regions and
planetary nebulae are different.Comment: 14 pages, 8 figures, 9 tables. Accepted for publication in the Ap
What Produced the Ultraluminous Supernova Remnant in NGC 6946?
The ultraluminous supernova remnant (SNR) in NGC 6946 is the brightest known
SNR in X-rays, ~1000 times brighter than Cas A. To probe the nature of this
remnant and its progenitor, we have obtained high-dispersion optical echelle
spectra. The echelle spectra detect H-alpha, [N II], and [O III] lines, and
resolve these lines into a narrow (FWHM ~20--40 km/s) component from un-shocked
material and a broad (FWHM ~250 km/s) component from shocked material. Both
narrow and broad components have unusually high [N II]/H-alpha ratios, ~1.
Using the echelle observation, archival HST images, and archival ROSAT X-ray
observations, we conclude that the SNR was produced by a normal supernova,
whose progenitor was a massive star, either a WN star or a luminous blue
variable. The high luminosity of the remnant is caused by the supernova ejecta
expanding into a dense, nitrogen-rich circumstellar nebula created by the
progenitor.Comment: 20 pages, 5 figures. To be published in The Astronomical Journal,
March 200
Auxiliary functions of the LISA laser link: ranging, clock noise transfer and data communication
The Laser Interferometer Space Antenna (LISA) is required to reduce two important noise sources by post-processing on the ground using time-delay interferometry (TDI): phase noise of the on-board reference clocks and laser frequency noise. To achieve the desired suppression, the TDI algorithm needs measurements of the differential clock noise between any two spacecraft and inter-spacecraft ranging measurements with at least 1 m accuracy, which is beyond the precision of ground-based measurements for deep space missions. Therefore, we need on-board measurements by transmitting clock noise and ranging information between the spacecraft as auxiliary functions of the laser link. This paper reports our current experimental results in clock noise transfer and ranging for noise subtraction via post-processing as well as additional data transfer
A Computer Application to Predict Adverse Events in the Short-Term Evolution of Patients With Exacerbation of Chronic Obstructive Pulmonary Disease
Background: Chronic obstructive pulmonary disease (COPD) is a common chronic disease. Exacerbations of COPD (eCOPD) contribute to the worsening of the disease and the patient’s evolution. There are some clinical prediction rules that may help to stratify patients with eCOPD by their risk of poor evolution or adverse events. The translation of these clinical prediction rules into computer applications would allow their implementation in clinical practice.
Objective: The goal of this study was to create a computer application to predict various outcomes related to adverse events of short-term evolution in eCOPD patients attending an emergency department (ED) based on valid and reliable clinical prediction rules.
Methods: A computer application, Prediction of Evolution of patients with eCOPD (PrEveCOPD), was created to predict 2 outcomes related to adverse events: (1) mortality during hospital admission or within a week after an ED visit and (2) admission to an intensive care unit (ICU) or an intermediate respiratory care unit (IRCU) during the eCOPD episode. The algorithms included in the computer tool were based on clinical prediction rules previously developed and validated within the Investigación en Resultados y Servicios de Salud COPD study. The app was developed for Windows and Android systems, using Visual Studio 2008 and Eclipse, respectively.
Results: The PrEveCOPD computer application implements the prediction models previously developed and validated for 2 relevant adverse events in the short-term evolution of patients with eCOPD. The application runs under Windows and Android systems and it can be used locally or remotely as a Web application. Full description of the clinical prediction rules as well as the original references is included on the screen. Input of the predictive variables is controlled for out-of-range and missing values. Language can be switched between English and Spanish. The application is available for downloading and installing on a computer, as a mobile app, or to be used remotely via internet.
Conclusions: The PrEveCOPD app shows how clinical prediction rules can be summarized into simple and easy to use tools, which allow for the estimation of the risk of short-term mortality and ICU or IRCU admission for patients with eCOPD. The app can be used on any computer device, including mobile phones or tablets, and it can guide the clinicians to a valid stratification of patients attending the ED with eCOPD.Fondo de Investigación Sanitaria (PI 06\1010, PI06\1017, PI06\714, PI06\0326, PI06\0664)
Departamento de Salud del Gobierno Vasco (2012111008)
Departamento de Educación, Política Lingüística y Cultura del Gobierno Vasco (IT620-13)
Ministerio de Economía y Competitividad del Gobierno Español and FEDER (MTM2013-40941-P and MTM2016-74931-P) the Research Committee of the Hospital Galdakao
the thematic networks -REDISSEC (Red de Investigación en Servicios de Salud en Enfermedades Crónicas) - of the Instituto de Salud Carlos III
A decision tree to assess short-term mortality after an emergency department visit for an exacerbation of COPD: A cohort study
Background: Creating an easy-to-use instrument to identify predictors of short-term (30/60-day) mortality after an exacerbation of chronic obstructive pulmonary disease (eCOPD) could help clinicians choose specific measures of medical care to decrease mortality in these patients. The objective of this study was to develop and validate a classification and regression tree (CART) to predict short term mortality among patients evaluated in an emergency department (ED) for an eCOPD. Methods: We conducted a prospective cohort study including participants from 16 hospitals in Spain. COPD patients with an exacerbation attending the emergency department (ED) of any of the hospitals between June 2008 and September 2010 were recruited. Patients were randomly divided into derivation (50 %) and validation samples (50 %). A CART based on a recursive partitioning algorithm was created in the derivation sample and applied to the validation sample. Results: Two thousand four hundred eighty-seven patients, 1252 patients in the derivation sample and 1235 in the validation sample, were enrolled in the study. Based on the results of the univariate analysis, five variables (baseline dyspnea, cardiac disease, the presence of paradoxical breathing or use of accessory inspiratory muscles, age, and Glasgow Coma Scale score) were used to build the CART. Mortality rates 30 days after discharge ranged from 0 % to 55 % in the five CART classes. The lowest mortality rate was for the branch composed of low baseline dyspnea and lack of cardiac disease. The highest mortality rate was in the branch with the highest baseline dyspnea level, use of accessory inspiratory muscles or paradoxical breathing upon ED arrival, and Glasgow score <15. The area under the receiver-operating curve (AUC) in the derivation sample was 0.835 (95 % CI: 0.783, 0.888) and 0.794 (95 % CI: 0.723, 0.865) in the validation sample. CART was improved to predict 60-days mortality risk by adding the Charlson Comorbidity Index, reaching an AUC in the derivation sample of 0.817 (95 % CI: 0.776, 0.859) and 0.770 (95 % CI: 0.716, 0.823) in the validation sample. Conclusions: We identified several easy-to-determine variables that allow clinicians to classify eCOPD patients by short term mortality risk, which can provide useful information for establishing appropriate clinical care. Trial registration: NCT02434536
Physical Structure of Small Wolf-Rayet Ring Nebulae
We have selected the seven most well-defined WR ring nebulae in the LMC (Br
2, Br 10, Br 13, Br 40a, Br 48, Br 52, and Br 100) to study their physical
nature and evolutionary stages. New CCD imaging and echelle observations have
been obtained for five of these nebulae; previous photographic imaging and
echelle observations are available for the remaining two nebulae. Using the
nebular dynamics and abundances, we find that the Br 13 nebula is a
circumstellar bubble, and that the Br 2 nebula may represent a circumstellar
bubble merging with a fossil main-sequence interstellar bubble. The nebulae
around Br 10, Br 52, and Br 100 all show influence of the ambient interstellar
medium. Their regular expansion patterns suggest that they still contain
significant amounts of circumstellar material. Their nebular abundances would
be extremely interesting, as their central stars are WC5 and WN3-4 stars whose
nebular abundances have not been derived previously. Intriguing and tantalizing
implications are obtained from comparisons of the LMC WR ring nebulae with ring
nebulae around Galactic WR stars, Galactic LBVs, LMC LBVs, and LMC BSGs;
however, these implications may be limited by small-number statistics. A SNR
candidate close to Br 2 is diagnosed by its large expansion velocity and
nonthermal radio emission. There is no indication that Br 2's ring nebula
interacts dynamically with this SNR candidate.Comment: 20 pages, Latex (aaspp4.sty), 2 figures, accepted by the Astronomical
Journal (March 99 issue
Carbon Nitrogen, and Oxygen Galactic Gradients: A Solution to the Carbon Enrichment Problem
Eleven models of Galactic chemical evolution, differing in the carbon,
nitrogen,and oxygen yields adopted, have been computed to reproduce the
Galactic O/H values obtained from H II regions. All the models fit the oxygen
gradient, but only two models fit also the carbon gradient, those based on
carbon yields that increase with metallicity due to stellar winds in massive
stars (MS) and decrease with metallicity due to stellar winds in low and
intermediate mass stars (LIMS). The successful models also fit the C/O versus
O/H evolution history of the solar vicinity obtained from stellar observations.
We also compare the present day N/H gradient and the N/O versus O/H and the
C/Fe, N/Fe, O/Fe versus Fe/H evolution histories of the solar vicinity
predicted by our two best models with those derived from H II regions and from
stellar observations. While our two best models fit the C/H and O/H gradients
as well as the C/O versus O/H history, only Model 1 fits well the N/H gradient
and the N/O values for metal poor stars but fails to fit the N/H values for
metal rich stars. Therefore we conclude that our two best models solve the C
enrichment problem, but that further work needs to be done on the N enrichment
problem. By adding the C and O production since the Sun was formed predicted by
Models 1 and 2 to the observed solar values we find an excellent agreement with
the O/H and C/H values of the solar vicinity derived from H II regions O and C
recombination lines. One of the most important results of this paper is that
the fraction of carbon due to MS and LIMS in the interstellar medium is
strongly dependent on time and on the galactocentric distance; at present about
half of the carbon in the interstellar medium of the solar vicinity has been
produced by MS and half by LIMS.Comment: 34 pages, 6 tables, 7 figures. Accepted for publication in Ap
Use of calculus of variations to determine the shape of hovering rotors of minimum power and its application to micro air vehicles
In this paper, calculus of variations and combined blade element and momentum theory (BEMT) are used to demonstrate that, in hover, when neither root nor tip losses are considered; the rotor, which minimizes the total power (MPR), generates an induced velocity that varies linearly along the blade span. The angle of attack of every blade element is constant and equal to its optimum value. The traditional ideal twist (ITR) and optimum (OR) rotors are revisited in the context of this variational framework. Two more optimum rotors are obtained considering root and tip losses, the ORL, and the MPRL. A comparison between these five rotors is presented and discussed. The MPR and MPRL present a remarkable saving of power for low values of both thrust coefficient and maximum aerodynamic efficiency. The result obtained can be exploited to improve the aerodynamic behaviour of rotary wing micro air vehicles (MAV). A comparison with experimental results obtained from the literature is presented
Testing matter effects in propagation of atmospheric and long-baseline neutrinos
We quantify our current knowledge of the size and flavor structure of the
matter effects in the evolution of atmospheric and long-baseline neutrinos
based solely on the analysis of the corresponding neutrino data. To this aim we
generalize the matter potential of the Standard Model by rescaling its
strength, rotating it away from the e-e sector, and rephasing it with respect
to the vacuum term. This phenomenological parametrization can be easily
translated in terms of non-standard neutrino interactions in matter. We show
that in the most general case, the strength of the potential cannot be
determined solely by atmospheric and long-baseline data. However its flavor
composition is very much constrained and the present determination of the
neutrino masses and mixing is robust under its presence. We also present an
update of the constraints arising from this analysis in the particular case in
which no potential is present in the e-mu and e-tau sectors. Finally we
quantify to what degree in this scenario it is possible to alleviate the
tension between the oscillation results for neutrinos and antineutrinos in the
MINOS experiment and show the relevance of the high energy part of the spectrum
measured at MINOS.Comment: PDFLaTeX file using JHEP3 class, 25 pages, 7 figures included.
Accepted for publication in JHE
Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study
Respiratory infections and tuberculosisInfecciones respiratorias y tuberculosisInfeccions respiratòries i tuberculosiDue to the large number of patients with severe coronavirus disease 2019 (COVID-19), many were treated outside the traditional walls of the intensive care unit (ICU), and in many cases, by personnel who were not trained in critical care. The clinical characteristics and the relative impact of caring for severe COVID-19 patients outside the ICU is unknown. This was a multinational, multicentre, prospective cohort study embedded in the International Severe Acute Respiratory and Emerging Infection Consortium World Health Organization COVID-19 platform. Severe COVID-19 patients were identified as those admitted to an ICU and/or those treated with one of the following treatments: invasive or noninvasive mechanical ventilation, high-flow nasal cannula, inotropes or vasopressors. A logistic generalised additive model was used to compare clinical outcomes among patients admitted or not to the ICU. A total of 40 440 patients from 43 countries and six continents were included in this analysis. Severe COVID-19 patients were frequently male (62.9%), older adults (median (interquartile range (IQR), 67 (55–78) years), and with at least one comorbidity (63.2%). The overall median (IQR) length of hospital stay was 10 (5–19) days and was longer in patients admitted to an ICU than in those who were cared for outside the ICU (12 (6–23) days versus 8 (4–15) days, p<0.0001). The 28-day fatality ratio was lower in ICU-admitted patients (30.7% (5797 out of 18 831) versus 39.0% (7532 out of 19 295), p<0.0001). Patients admitted to an ICU had a significantly lower probability of death than those who were not (adjusted OR 0.70, 95% CI 0.65–0.75; p<0.0001). Patients with severe COVID-19 admitted to an ICU had significantly lower 28-day fatality ratio than those cared for outside an ICU.This work was supported by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z), the Bill and Melinda Gates Foundation (OPP1209135), Canadian Institutes of Health Research Coronavirus Rapid Research Funding Opportunity OV2170359, grants from Rapid European COVID-19 Emergency Response Research (Horizon 2020 project 101003589), the European Clinical Research Alliance on Infectious Diseases (965313), The Imperial National Institute for Health Research (NIHR) Biomedical Research Centre, and The Cambridge NIHR Biomedical Research Centre; and endorsed by the Irish Critical Care Clinical Trials Group, co-ordinated in Ireland by the Irish Critical Care Clinical Trials Network at University College Dublin and funded by the Health Research Board of Ireland (CTN-2014-12). Data and Material provision was supported by grants from: the NIHR (award CO-CIN-01), the Medical Research Council (grant MC_PC_19059), the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with Public Health England (PHE) (award 200907), Wellcome Trust (Turtle, Lance-fellowship 205228/Z/16/Z), NIHR HPRU in Respiratory Infections at Imperial College London with PHE (award 200927), Liverpool Experimental Cancer Medicine Centre (grant C18616/A25153), NIHR Biomedical Research Centre at Imperial College London (award IS-BRC-1215-20013), and NIHR Clinical Research Network providing infrastructure support. This work was by Research Council of Norway grant number 312780, and a philanthropic donation from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner
- …