An action-oriented approach to didactic dubbing in foreign language education: Students as producers

This article discusses the action-oriented foundations of TRADILEX (Audiovisual Translation as a Didactic Resource in Foreign Language Education), a project funded by the Spanish Ministry of Science and Innovation, which involves researchers from twelve universities across Europe and the UK. This project focuses on the improvement in the linguistic skills perceived through audiovisual translation (AVT) practices such as the use of captioning (i.e., interlingual and intralingual subtitling) and revoicing (i.e., dubbing, voice-over, and audio description) through an actionoriented approach (AoA). The ultimate objective is the study of AVT as a means to enhance learners’ communicative competence and reception, production, and mediation skills in an integrated manner. Following the design of a methodological proposal for a didactic sequence of AVT tasks, proposals are currently being piloted with B1 and B2 adult learners of English as a foreign language utilising – and adapting – the recent illustrative descriptors (Council of Europe, 2018) for AVT instruction. The potential benefits of action-oriented AVT tasks in foreign language education (FLE), in which foreign-language learners become active producers of AVT work, are put to the test employing empirical inquiry and thereafter advocating for more comprehensive integration of AVT in the FLE curriculum overall

Deep-water turbidite systems: a review of their elements, sedimentary processes and depositional models. Their characteristics on the Iberian margins - Sistemas turbidíticos de aguas profundas: revisión de sus elementos, procesos sedimentarios y modelos deposicionales. Sus características en los márgenes Ibéricos

Turbidite systems or submarine fans are considered the most important clastic accumulations in the deep sea and represent the sediment-transfer system between the hinterland source area and the deep-sea depositional sink. Their deposits contain information about global factors and local factors. Different scales and varying observational methods have contributed to the lack of a unifying terminology. In order to solve this problem several authors have proposed an “elemental approach”. The main architectural elements defining a turbidite system are: large-scale erosive features (mass-movements and canyons), channels and channel-fill deposits, overbank deposits and lobes. The sediment making up these elements is principally from gravity flow deposits, the most widely recognised being the turbidite, and other submarine mass movements. The genesis and character of these elements, as well as the overall geometry of the systems, indicate they are formed by a complex interaction between global and local factors. Various turbidite-system classifications are found in the literature, the most widely-used being based on grain size and feeder systems. Besides the scientific importance of turbiditic systems, they are predominantly studied because of the economic interest in them, as turbidite sandstones constitute important gas and oil reservoirs. Turbidite systems shape the seafloor of the Iberian continental margins and contribute in a large part to their outbuilding and basin infilling. They are hugely variable in size, location within the physiographic domains, style and overall geometry of the architectural elements, as well as sediment composition. The most studied Iberian turbidite fans are in the Mediterranean Sea whereas those of the Atlantic Ocean remain poorly known

New evidence of the Green Tuff deposits and post-caldera, recent explosive volcanic activity at Pantelleria volcano (Sicily Channel, Italy) recorded in near-vent marine areas

The record of the explosive activity of Pantelleria volcano is well documented by several distal tephra collected in various areas in and around the Mediterranean, while few tephrochronological studies exist on proximal marine areas. In this paper, we investigate three selected coring sites from the northern shoulder of the Pantelleria graben, about 15–30 km from the island, in near-vent position with respect to that volcanic source. Our multiproxy analyses revealed nine tephra layers, totally composed of juvenile materials, mostly ash and pumice fragments, as well as a coarse-grained tephra deposit at the bottom of one of the cores. The major element composition of glass shards indicates a very homogeneous geochemical composition for the tephra layers, suggesting their primary origin. Using litho-stratigraphic and paleoenvironmental proxies, we associated the tephra layers to the latest (<∼13.7 ka) explosive activity of Pantelleria. The coarse-grained deposit, instead, due to its distinctive composition is considered to represent the near-vent, marine equivalent of the distal Y-6 tephra layer, related to the ∼45 ka old co-ignimbrite fallout deposit of the Green Tuff event. The geochemical characterization of such deposit, mostly rhyolitic and partly trachytic, appears to enlarge the bimodal composition recorded in other distal tephra (Y-6) reported in the literature, highlighting the potential of near-vent record in providing additional information on the eruptive history

APPLICATION OF THE THEORY OF PEPLAU TO THE HOME CARE OF A PATIENT WITH AIDS

Descreve-se um estudo de caso clínico, realizado com um paciente portador de AIDS, baseado no referencial teórico de Peplau, em que se utilizou a taxonomia de diagnósticos de enfermagem da North American Nursing Diagnoses Association (NANDA) para retratar as respostas do paciente à situação de saúde que vivenciava. Foram realizadas 07 (sete) visitas domiciliares ao paciente, durante as quais utilizou-se a entrevista e a observação como técnicas de coleta de dados, dando-se ênfase às necessidades humanas básicas. No processo de assistência, foram identificados e tratados 03 (três) diagnósticos de enfermagem – Potencial para infecção; Potencial para déficit do volume de líquido; e Baixa auto-estima: situacional.This is a case study about a patient with AIDS, recently admitted to the home-care program of the University Hospital of the Federal University of Pernambuco for continuation of his treatment. The objective of this study is to describe an application of the nursing process in the area of home-care based on the Interpersonal Relations Theory of Peplau. Taxonomy I of the North American Nursing Diagnosis Association (NANDA) was used as a framework for portraying patient reponses regarding his lived health situation. Seven domiciliary visits were made during which data were gathered through systematic observation and a semi-structured interview with an emphasis on basic human needs. Three NANDA nursing diagnoses (Risk for Infection; Fluid Volume Deficit; and Situational Low Self Esteem) were identified for which interventions were planned and implemented

Geomorphic and shallow-acoustic investigation of an Antarctic Peninsula fjord system using high-resolution ROV and shipboard geophysical observations: Ice dynamics and behaviour since the Last Glacial Maximum

© 2016 Detailed bathymetric and sub-bottom acoustic observations in Bourgeois Fjord (Marguerite Bay, Antarctic Peninsula) provide evidence on sedimentary processes and glacier dynamics during the last glacial cycle. Submarine landforms observed in the 50 km-long fjord, from the margins of modern tidewater glaciers to the now ice-distal Marguerite Bay, are described and interpreted. The landforms are grouped into four morpho-sedimentary systems: (i) glacial advance and full-glacial; (ii) subglacial and ice-marginal meltwater; (iii) glacial retreat and neoglaciation; and (iv) Holocene mass-wasting. These morpho-sedimentary systems have been integrated with morphological studies of the Marguerite Bay continental shelf and analysed in terms of the specific sedimentary processes and/or stages of the glacial cycle. They demonstrate the action of an ice-sheet outlet glacier that produced drumlins and crag-and-tail features in the main and outer fjord. Meltwater processes eroded bedrock channels and ponds infilled by fine-grained sediments. Following the last deglaciation of the fjord at about 9000 yr BP, subsequent Holocene neoglacial activity involved minor readvances of a tidewater glacier terminus in Blind Bay. Recent stillstands and/or minor readvances are inferred from the presence of a major transverse moraine that indicates grounded ice stabilization, probably during the Little Ice Age, and a series of smaller landforms that reveal intermittent minor readvances. Mass-wasting processes also affected the walls of the fjord and produced scars and fan-shaped deposits during the Holocene. Glacier-terminus changes during the last six decades, derived from satellite images and aerial photographs, reveal variable behaviour of adjacent tidewater glaciers. The smaller glaciers show the most marked recent retreat, influenced by regional physiography and catchment-area size

Longitudinal study of the immune response and memory following natural bovine respiratory syncytial virus infections in cattle of different age

Human and bovine respiratory syncytial virus (HRSV and BRSV) are closely genetically related and cause respiratory disease in their respective host. Whereas HRSV vaccines are still under development, a multitude of BRSV vaccines are used to reduce clinical signs. To enable the design of vaccination protocols to entirely stop virus circulation, we aimed to investigate the duration, character and efficacy of the immune responses induced by natural infections. The systemic humoral immunity was monitored every two months during two years in 33 dairy cattle in different age cohorts following a natural BRSV outbreak, and again in selected individuals before and after a second outbreak, four years later. Local humoral and systemic cellular responses were also monitored, although less extensively. Based on clinical observations and economic losses linked to decreased milk production, the outbreaks were classified as moderate. Following the first outbreak, most but not all animals developed neutralising antibody responses, BRSV-specific IgG1, IgG2 and HRSV F- and HRSV N-reactive responses that lasted at least two years, and in some cases at least four years. In contrast, no systemic T cell responses were detected and only weak IgA responses were detected in some animals. Seronegative sentinels remained negative, inferring that no new infections occurred between the outbreaks. During the second outbreak, reinfections with clinical signs and virus shedding occurred, but the signs were milder, and the virus shedding was significantly lower than in naïve animals. Whereas the primary infection induced similar antibody titres against the prefusion and the post fusion form of the BRSV F protein, memory responses were significantly stronger against prefusion F. In conclusion, even if natural infections induce a long-lasting immunity, it would probably be necessary to boost memory responses between outbreaks, to stop the circulation of the virus and limit the potential role of previously infected adult cattle in the chain of BRSV transmission

Ponatinib promotes a G1 cell-cycle arrest of merlin/NF2-deficient human schwann cells

Neurofibromatosis type 2 (NF2) is a genetic syndrome that predisposes individuals to multiple benign tumors of the central and peripheral nervous systems, including vestibular schwannomas. Currently, there are no FDA approved drug therapies for NF2. Loss of function of merlin encoded by the NF2 tumor suppressor gene leads to activation of multiple mitogenic signaling cascades, including platelet-derived growth factor receptor (PDGFR) and SRC in Schwann cells. The goal of this study was to determine whether ponatinib, an FDA-approved ABL/SRC inhibitor, reduced proliferation and/or survival of merlin-deficient human Schwann cells (HSC). Merlin-deficient HSC had higher levels of phosphorylated PDGFRα/β, and SRC than merlin-expressing HSC. A similar phosphorylation pattern was observed in phospho-protein arrays of human vestibular schwannoma samples compared to normal HSC. Ponatinib reduced merlin-deficient HSC viability in a dose-dependent manner by decreasing phosphorylation of PDGFRα/β, AKT, p70S6K, MEK1/2, ERK1/2 and STAT3. These changes were associated with decreased cyclin D1 and increased p27Kip1levels, leading to a G1 cell-cycle arrest as assessed by Western blotting and flow cytometry. Ponatinib did not modulate ABL, SRC, focal adhesion kinase (FAK), or paxillin phosphorylation levels. These results suggest that ponatinib is a potential therapeutic agent for NF2-associated schwannomas and warrants further in vivo investigation

Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome

Background: Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Methods: Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed ≥ 10% eGFR decline or ≥10% UACR increase. Results: After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, β: -0.64 ml/min/1.73 m2; 95% CI: -1.21 to -0.08 and NEAP, β: -0.56 ml/min/1.73 m2; 95% CI: -1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing ≥10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07-1.54 and NEAP, OR: 1.24; 95% CI: 1.03-1.50) and ≥10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04-1.46) compared to individuals with lower dietary acid load. Conclusions: Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity and metabolic syndrome. Keywords: albuminuria; chronic kidney disease (CKD); dietary acid load; glomerular filtration rate (GFR); kidney function; net endogenous acid production (NEAP); potential renal acid load (PRAL); renal nutrition