Myasthenia Gravis

Poster Abstract Jonathan C. Garcia Department of Nursing, Otterbein University NURS 6810 – Advanced Pathophysiology for the Advanced Practice Nurse Dr. Deana Batross and Dr. Shivani Bhatnagar July 29, 2022 Abstract Myasthenia Gravis (MG) is a rare autoimmune neuromuscular disorder caused by the destruction or decreased availability of nicotinic acetylcholine receptors in the post-synaptic neuromuscular junction. Muscular weakness that worsens with activity and improves with rest is a hallmark of MG. MG patients are at increased risk for many postoperative and anesthesia-related complications. However, risk can be mitigated when providers thoroughly understand MG\u27s pathophysiology and implications on the anesthetic plan. Particular attention should be given to the preoperative physical assessment, drug selection and dosing for induction, curarization, and reversal of neuromuscular blockade, and having specific extubation criteria to avoid postoperative complications. This poster provides education related to the pathophysiology, signs and symptoms, treatment, and nursing implications pertaining to MG with the hope that outcomes for MG patients can be positively influenced

The heterogeneous gas with singular interaction: Generalized circular law and heterogeneous renormalized energy

We introduce and analyze $d$ dimensional Coulomb gases with random charge distribution and general external confining potential. We show that these gases satisfy a large deviations principle. The analysis of the minima of the rate function (which is the leading term of the energy) reveals that at equilibrium, the particle distribution is a generalized circular law (i.e. with spherical support but non-necessarily uniform distribution). In the classical electrostatic external potential, there are infinitely many minimizers of the rate function. The most likely macroscopic configuration is a disordered distribution in which particles are uniformly distributed (for $d=2$, the circular law), and charges are independent of the positions of the particles. General charge-dependent confining potentials unfold this degenerate situation: in contrast, the particle density is not uniform, and particles spontaneously organize according to their charge. In that picture the classical electrostatic potential appears as a transition at which order is lost. Sub-leading terms of the energy are derived: we show that these are related to an operator, generalizing the Coulomb renormalized energy, which incorporates the heterogeneous nature of the charges. This heterogeneous renormalized energy informs us about the microscopic arrangements of the particles, which are non-standard, strongly depending on the charges, and include progressive and irregular lattices.Comment: 26 pages, 10 figure

Financial Performance in Upstream, Downstream, and Integrated Oil Companies in Response to Oil Price Volatility

This paper investigates the relation between crude oil price volatility and stock returns among oil companies using a three-part methodology, by using the West Texas Intermediate (WTI) as oil price benchmark. I asses the various indicators that set signals for oil price volatility and the interpretation of each (PMI, S&P500, DJIA, and World Crude Oil Output). This research also focuses on the relation between different types of companies in the oil industry (integrated, upstream, and downstream) and how each type of company will be assessed in a particular way to predict abnormal returns, based on market data and statistical analyses results and interpretation

Economic tradeoff between biochar and bio-oil production via pyrolysis

This paper examines some of the economic tradeoffs in the joint production of biochar and bio-oil from cellulosic biomass. The pyrolysis process can be performed with different final temperatures, and with different heating rates. While most carbonization technologies operating at low heating rates result in higher yields of charcoal, fast pyrolysis is the technology of choice to produce bio-oils. Varying operational and design parameters can change the relative quantity and quality of biochar and bio-oil produced for a given feedstock. These changes in quantity and quality of both products affect the potential revenue from their production and sale. We estimate quadratic production functions for biochar and bio-oil. The results are then used to calculate a product transformation curve that characterizes the yields of bio-oil and biochar that can be produced for a given amount of feedstock, movement along the curve corresponds to changes in temperatures, and it can be used to infer optimal pyrolysis temperature settings for a given ratio of biochar and bio-oil prices.biochar, bio-oil, pyrolysis, biomass conversion, economic tradeoff

CP Violation and F-theory GUTs

Recent work on F-theory GUTs has shown that the predicted masses, and magnitudes of the mixing matrix elements in the quark and lepton sectors are in close accord with experiment. In this note we estimate the CP violating phase of the mixing matrices by considering the Jarlskog invariant. We find by carefully treating certain cancellations in the computation of the Jarlskog invariant that |J_quark| ~ alpha_GUT^(3) ~ 6*10^(-5), and that the CP violating phase of the quark sector is large, in accord with experiment. Moreover, we predict (up to order one factors) that |J_lepton| ~ alpha_GUT ~ 4*10^(-2) and that the CP violating phase of the lepton sector is also large.Comment: v2: 3 pages, Improved estimate of the Jarlskog invariant involving subtle cancellations, leading to a different conclusion for the CP violating phas

The design and verification of Mumax3

We report on the design, verification and performance of mumax3, an open-source GPU-accelerated micromagnetic simulation program. This software solves the time- and space dependent magnetization evolution in nano- to micro scale magnets using a finite-difference discretization. Its high performance and low memory requirements allow for large-scale simulations to be performed in limited time and on inexpensive hardware. We verified each part of the software by comparing results to analytical values where available and to micromagnetic standard problems. mumax3 also offers specific extensions like MFM image generation, moving simulation window, edge charge removal and material grains

Endocuff Vision Reduces Inspection Time Without Decreasing Lesion Detection in a Randomized Colonoscopy Trial

Background & Aims Mucosal exposure devices improve detection of lesions during colonoscopy and have reduced examination times in uncontrolled studies. We performed a randomized trial of Endocuff Vision vs standard colonoscopy to compare differences in withdrawal time (the primary end point). We proposed that Endocuff Vision would allow complete mucosal inspection in a shorter time without impairing lesion detection. Methods Adults older than 40 years undergoing screening or surveillance colonoscopies were randomly assigned to the Endocuff group (n=101, 43.6% women) or the standard colonoscopy group (n=99; 57.6% women). One of 2 experienced endoscopists performed the colonoscopies, aiming for a thorough evaluation of the proximal sides of all haustral folds, flexures, and valves in the shortest time possible. Inspection time was measured with a stopwatch and calculated by subtracting washing, suctioning, polypectomy and biopsy times from total withdrawal time. Results There were significantly fewer women in the Endocuff arm (P = .0475) but there were no other demographic differences between groups. Mean insertion time with Endocuff was 4.0 min vs 4.4 min for standard colonoscopy (P = .14). Mean inspection time with Endocuff was 6.5 min vs 8.4 min for standard colonoscopy (P < .0001). Numbers of adenomas detected per colonoscopy (1.43 vs 1.07; P = .07), adenoma detection rate (61.4% vs 52%; P = .21), number of sessile serrated polyps per colonoscopy (0.27 vs 0.21; P = .12), and sessile serrated polyp detection rate (19.8% vs 11.1%; P = .09) were all higher with Endocuff Vision. Results did not differ significantly when we controlled for age, sex, or race. Conclusion In a randomized trial, we found inclusion of Endocuff in screening or surveillance colonoscopies to decrease examination time without reducing lesion detection