Estatus epiléptico refractario no convulsionante en postoperatorio de pancreatectomía total: A propósito de un caso

We present a clinical case of non-convulsive epileptic status in the post-operative of a 79-year-old patient with no history of epilepsy, and its probable relationship with scheduled antibiotic therapy. Then a discussion about the epileptic status and its appearance as a side effect of the treatment with certain antibiotics is made.Se presenta un caso clinico de Estatus Epileptico No convulsionante en el posopoeratorio de una paciente de 79 años sin antecedentes de epilepsia, y su probable relación con la antibioterapia pautada. Seguidamente se realiza una discusion acerca del estatus epileptico y su aparicion como efecto secundario del tratamiento con ciertos antibioticos.

Use of Recycled Aggregates from Demolition Wastes in Concrete: Acoustic Properties

The construction industry is one of the most demanding in terms of natural resources, and of the most polluting in terms of emissions to the atmosphere. Concrete is one of the most used materials in engineering and is a paradigm of the consumption of rocks for aggregates, used in polluting industries such as cement production. In trying to reduce the consumption of natural resources, efforts are being made to use waste as recycled aggregates. This fact has evident economic and environmental advantages, but it has a drawback. The concrete prepared with recycled aggregates has lower mechanical strength than ordinary concrete. This decrease of resistance is mainly due to a higher porosity exhibited by the materials from recycled aggregates. But the increase of porosity can be a great advantage in terms of sound absorption. In this work several types of recycled aggregates have been tested, paying special attention to their acoustic behaviour and pore structure. The results show that concrete made with recycled waste are effective in absorbing sound. It might become an alternative to traditional concrete, since recycling samples behave similarly or better in terms of sound absorption, using recycled materials, and increasing their life-cycle. The measurement of acoustic properties, as well as density, has already been undertaken in previous works. This work presents an image analysis methodology that is completely novel, and that helps to understand the acoustic behaviour of concrete elements

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Historial meteorology and his contribution to aerospace research

[ES]Este artículo describe un breve resumen histórico de la meteorología, su desarrollo científico y experimental en los últimos cien años, sus aplicaciones, en especial a la aviación y, últimamente, a la investigación aeroespacial con mención al planeta Marte y su atmósfera.[EN]This article describes a brief historical summary of meteorology, its scientific and experimental development in the last hundred years, its applications, especially to aviation and, lately, to aerospace research with mention of the planet Mars and its atmosphere

Carbon utilization by fruit limits shoot growth in alternate-bearing citrus trees

[EN] Fruit load in alternate-bearing citrus trees is reported to alter shoot number and growth during spring, summer, and autumn flushes, and the source-sink balance, which affects the storage and mobilization of reserve nutrients. The aim of this work was to assess the extent of shoot growth inhibition resulting from the presence of fruits in ` Moncada' mandarin trees loaded with fruit (ON) or with very light fruit load (OFF), and to identify the role of carbohydrates and nitrogenous compounds in the competition between fruits and shoots. Growth of reproductive and vegetative organs was measured on a monthly basis. C-13-and N-15-labeled compounds were supplied to trace the allocation of reserve nutrients and subsequent translocation from source to sink. At the end of the year, OFF trees produced more abundant flushes (2.4-and 4.9-fold higher in number and biomass, respectively) than ON trees. Fruits from ON trees accumulated higher C amounts at the expense of developing flushes, whereas OFF trees exhibited the opposite pattern. An inverse relationship was identified between the amount of C utilized by fruits and vegetative flush growth. C-13-labeling revealed an important role for mature leaves of fruit-bearing branches in supporting shoot/fruit growth, and the elevated sink strength of growing fruits on shoots. N availability for vegetative shoots was not affected by the presence or absence of fruits, which accumulated important amounts of N-15. In conclusion, our results show that shoot growth is resource-limited as a consequence of fruit development, and vegetative-growth inhibition is caused by photoassimilate limitation. The competence for N is not a decisive factor in limiting vegetative growth under the experimental conditions of this study. (C) 2014 Elsevier GmbH. All rights reserved.This work was supported by grants from the Instituto Nacional de Investigaciones Agrarias, Spain (RTA2009-00147 and RTA2011-00114-00-00).Martinez-Alcantara, B.; Iglesias, DJ.; Reig Valor, C.; Mesejo Conejos, C.; Agustí Fonfría, M.; Primo-Millo, E. (2015). Carbon utilization by fruit limits shoot growth in alternate-bearing citrus trees. Journal of Plant Physiology. 176:108-117. https://doi.org/10.1016/j.jplph.2014.12.001S10811717