Assessment of fissionable material behaviour in fission chambers

A comprehensive study is performed in order to assess the pertinence of fission chambers coated with different fissile materials for high neutron flux detection. Three neutron scenarios are proposed to study the fast component of a high neutron flux: (i) high neutron flux with a significant thermal contribution such as BR2, (ii) DEMO magnetic fusion reactor, and (iii) IFMIF high flux test module. In this study, the inventory code ACAB is used to analyze the following questions: (i) impact of different deposits in fission chambers; (ii) effect of the irradiation time/burn-up on the concentration; (iii) impact of activation cross-section uncertainties on the composition of the deposit for all the range of burn-up/irradiation neutron fluences of interest. The complete set of nuclear data (decay, fission yield, activation cross-sections, and uncertainties) provided in the EAF2007 data library are used for this evaluation

SAT based Enforcement of Domotic Effects in Smart Environments

The emergence of economically viable and efficient sensor technology provided impetus to the development of smart devices (or appliances). Modern smart environments are equipped with a multitude of smart devices and sensors, aimed at delivering intelligent services to the users of smart environments. The presence of these diverse smart devices has raised a major problem of managing environments. A rising solution to the problem is the modeling of user goals and intentions, and then interacting with the environments using user defined goals. `Domotic Effects' is a user goal modeling framework, which provides Ambient Intelligence (AmI) designers and integrators with an abstract layer that enables the definition of generic goals in a smart environment, in a declarative way, which can be used to design and develop intelligent applications. The high-level nature of domotic effects also allows the residents to program their personal space as they see fit: they can define different achievement criteria for a particular generic goal, e.g., by defining a combination of devices having some particular states, by using domain-specific custom operators. This paper describes an approach for the automatic enforcement of domotic effects in case of the Boolean application domain, suitable for intelligent monitoring and control in domotic environments. Effect enforcement is the ability to determine device configurations that can achieve a set of generic goals (domotic effects). The paper also presents an architecture to implement the enforcement of Boolean domotic effects, and results obtained from carried out experiments prove the feasibility of the proposed approach and highlight the responsiveness of the implemented effect enforcement architectur

A Bayesian method for point source polarization estimation

The estimation of the polarization $P$ of extragalactic compact sources in Cosmic Microwave Background images is a very important task in order to clean these images for cosmological purposes -- as, for example, to constrain the tensor-to-scalar ratio of primordial fluctuations during inflation -- and also to obtain relevant astrophysical information about the compact sources themselves in a frequency range, $\nu \sim 10$--$200$ GHz, where observations have only very recently started to be available. In this paper we propose a Bayesian maximum a posteriori (MAP) approach estimation scheme which incorporates prior information about the distribution of the polarization fraction of extragalactic compact sources between 1 and 100 GHz. We apply this Bayesian scheme to white noise simulations and to more realistic simulations that include CMB intensity, Galactic foregrounds and instrumental noise with the characteristics of the QUIJOTE experiment Wide Survey at 11 GHz. Using these simulations, we also compare our Bayesian method with the frequentist Filtered Fusion method that has been already used in WMAP data and in the \emph{Planck} mission. We find that the Bayesian method allows us to decrease the threshold for a feasible estimation of $P$ to levels below $\sim 100$ mJy (as compared to $\sim 500$ mJy that was the equivalent threshold for the frequentist Filtered Fusion). We compare the bias introduced by the Bayesian method and find it to be small in absolute terms. Finally, we test the robustness of the Bayesian estimator against uncertainties in the prior and in the flux density of the sources. We find that the Bayesian estimator is robust against moderate changes in the parameters of the prior and almost insensitive to realistic errors in the estimated photometry of the sources.Comment: 15 pages, 12 figures, submitted to A&

Revealing hidden clonal complexity in Mycobacterium tuberculosis infection by qualitative and quantitative improvement of sampling

AbstractThe analysis of microevolution events, its functional relevance and impact on molecular epidemiology strategies, constitutes one of the most challenging aspects of the study of clonal complexity in infection by Mycobacterium tuberculosis. In this study, we retrospectively evaluated whether two improved sampling schemes could provide access to the clonal complexity that is undetected by the current standards (analysis of one isolate from one sputum). We evaluated in 48 patients the analysis by mycobacterial interspersed repetitive unit–variable number tandem repeat of M. tuberculosis isolates cultured from bronchial aspirate (BAS) or bronchoalveolar lavage (BAL) and, in another 16 cases, the analysis of a higher number of isolates from independent sputum samples. Analysis of the isolates from BAS/BAL specimens revealed clonal complexity in a very high proportion of cases (5/48); in most of these cases, complexity was not detected when the isolates from sputum samples were analysed. Systematic analysis of isolates from multiple sputum samples also improved the detection of clonal complexity. We found coexisting clonal variants in two of 16 cases that would have gone undetected in the analysis of the isolate from a single sputum specimen. Our results suggest that analysis of isolates from BAS/BAL specimens is highly efficient for recording the true clonal composition of M. tuberculosis in the lungs. When these samples are not available, we recommend increasing the number of isolates from independent sputum specimens, because they might not harbour the same pool of bacteria. Our data suggest that the degree of clonal complexity in tuberculosis has been underestimated because of the deficiencies inherent in a simplified procedure

Differences in the robustness of clusters involving the Mycobacterium tuberculosis strains most frequently isolated from immigrant cases in Madrid

AbstractTuberculosis cases infected by the same Mycobacterium tuberculosis (MTB) strain are considered to be clustered and involved in a transmission chain. Large clusters are assumed to represent active transmission chains in a population. In the present study, we focused on the analysis of large clusters defined by IS6110-restriction fragment length polymorphism (RFLP) typing in the immigrant population in Madrid. We identified 12 large clusters (involving 43% of the isolates) comprising 4–23 representatives. We proposed a gradient of epidemiological certainty for these large clusters. For a cluster to be considered robust and a good indicator of recent transmission, the MTB strain involved should not have been identified in a geographically and epidemiologically unrelated population and the cluster had to be re-confirmed by another highly discriminative molecular marker (MIRU-VNTR). The clusters that we discovered were classified into three categories: high, intermediate and low expected epidemiological value. In the largest cluster in the study (cluster M6; 23 representatives), failures by both criteria were identified: the representative seven-band RFLP pattern was also the most prevalent in the unrelated population (25 cases) and the cluster was fully split by MIRU-15, suggesting a lack of epidemiological value. The RFLP pattern representative of this cluster was also identified in 64 isolates from five countries in the Latin American genotype database, and again proved to be heterogeneous according to the MIRU-15 analysis. Specific analysis of large clusters, combined with the application of criteria for evaluating their robustness, could help identify uninformative clusters and target epidemiological resources towards those clusters with higher expected epidemiological value

Characterization of Mycobacterium tuberculosis Beijing isolates from the Mediterranean area

<p>Abstract</p> <p>Background</p> <p>The Beijing lineage of <it>Mycobacterium tuberculosis </it>is causing concern due to its global distribution and its involvement in severe outbreaks. Studies focused on this lineage are mainly restricted to geographical settings where its prevalence is high, whereas those in other areas are scarce. In this study, we analyze Beijing isolates in the Mediterranean area, where this lineage is not prevalent and is mainly associated with immigrant cases.</p> <p>Results</p> <p>Only 1% (N = 26) of the isolates from two population-based studies in Spain corresponded to Beijing strains, most of which were pan-susceptible and from Peruvian and Ecuadorian patients. Restriction fragment length polymorphism typing with the insertion sequence IS<it>6110 </it>identified three small clusters (2-3 cases). Mycobacterial interspersed repetitive unit-variable number tandem repeat typing (MIRU-15) offered low discriminatory power, requiring the introduction of five additional loci. A selection of the Beijing isolates identified in the Spanish sample, together with a sample of Beijing strains from Italy, to broaden the analysis context in the Mediterranean area, were assayed in an infection model with THP-1 cells. A wide range of intracellular growth rates was observed with only two isolates showing an increased intracellular replication, in both cases associated with contained production of TNF-α. No correlation was observed between virulence and the Beijing phylogenetic group, clustered/orphan status, or resistance. The Beijing strain responsible for extensive spread on Gran Canaria Island was also identified in Madrid, but did not lead to secondary cases and did not show high infectivity in the infection model.</p> <p>Conclusions</p> <p>The Beijing lineage in our area is a non-homogeneous family, with only certain highly virulent representatives. The specific characterization of Beijing isolates in different settings could help us to accurately identify the virulent representatives before making general assumptions about this lineage.</p

Influence of chronic ocular hypertension on emmetropia: Refractive, structural and functional study in two rat models

Chronic ocular hypertension (OHT) influences on refraction in youth and causes glaucoma in adulthood. However, the origin of the responsible mechanism is unclear. This study analyzes the effect of mild-moderate chronic OHT on refraction and neuroretina (structure and function) in young-adult Long-Evans rats using optical coherence tomography and electroretinography over 24 weeks. Data from 260 eyes were retrospectively analyzed in two cohorts: an ocular normotension (ONT) cohort (20 mmHg), in which OHT was induced either by sclerosing the episcleral veins (ES group) or by injecting microspheres into the anterior chamber. A trend toward emmetropia was found in both cohorts over time, though it was more pronounced in the OHT cohort (p < 0.001), especially in the ES group (p = 0.001) and males. IOP and refraction were negatively correlated at week 24 (p = 0.010). The OHT cohort showed early thickening in outer retinal sectors (p < 0.050) and the retinal nerve fiber layer, which later thinned. Electroretinography demonstrated early supranormal amplitudes and faster latencies that later declined. Chronic OHT accelerates emmetropia in Long–Evans rat eyes towards slowly progressive myopia, with an initial increase in structure and function that reversed over time. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Peculiarities of the stochastic motion in antiferromagnetic nanoparticles

Antiferromagnetic (AFM) materials are widely used in spintronic devices as passive elements (for stabilization of ferromangetic layers) and as active elements (for information coding). In both cases switching between the different AFM states depends in a great extent from the environmental noise. In the present paper we derive the stochastic Langevin equations for an AFM vector and corresponding Fokker-Planck equation for distribution function in the phase space of generalised coordinate and momentum. Thermal noise is modeled by a random delta-correlated magnetic field that interacts with the dynamic magnetisation of AFM particle. We analyse in details a particular case of the collinear compensated AFM in the presence of spin-polarised current. The energy distribution function for normal modes in the vicinity of two equilibrium states (static and stationary) in sub- and super-critical regimes is found. It is shown that the noise-induced dynamics of AFM vector has pecuilarities compared to that of magnetisation vector in ferromagnets.Comment: Submitted to EPJ ST, presented at the 4-th Conference on Statistical Physics, Lviv, Ukraine, 201

Education and Training of Future Nuclear Engineers at DIN: From Advanced Computer Codes to an Interactive Plant Simulator

ABSTRACT This paper summarizes the work being performed at the Department of Nuclear Engineering (www.din.upm.es) of the Universidad Politécnica de Madrid to improve the education and training of future Spanish nuclear engineers according to the Bologna rules. We present two main efforts introduced in our programme: i) the understanding of the current computational methodologies/codes starting from the nuclear data processing, then the lattice and core calculations codes, and finally the power plant simulators, ii) the development of practical teaching-learning experiences with an Interactive Graphical Simulator of a real nuclear power plant