Estimating the one-repetition maximum on the leg-press exercise in female breast cancer survivors

We examined the accuracy of twelve different velocity-based methods for predicting the bilateral leg-press exercise one-repetition maximum (1RM) in breast cancer survivors. Twenty-one female breast cancer survivors (age 50.2 ± 10.8 years) performed an incremental loading test up to the 1RM. Individual load-velocity relationships were modeled by linear and quadratic polynomial regression models considering the mean velocity (MV) and peak velocity (PV) values recorded at five incremental loads (~45-55-65-75-85% of 1RM) (multiple-point methods) and by a linear regression model considering only the two distant loads (~45–85% of 1RM) (two-point method). The 1RM was always estimated through these load-velocity relationships as the load associated with a general (MV: 0.24 m/s; PV: 0.60 m/s) and an individual (MV and PV of the 1RM trial) minimal velocity threshold (MVT). Compared to the actual 1RM, the 1RMs estimated by all linear regression models showed trivial differences (Hedge’s g ranged from 0.08 to 0.17), very large to nearly perfect correlations (r ranged from 0.87 to 0.95), and no heteroscedasticity of the errors (coefficient of determination (r2) < 0.10 obtained from the relationship of the raw differences between the actual and predicted 1RMs with their average value). Given the acceptable and comparable accuracy for all 1RM linear prediction methods, the two-point method and a general MVT could be recommended to simplify the testing procedure of the bilateral leg-press 1RM in breast cancer survivorsPatronato Municipal de Deportes, Ayuntamiento de Almería, University of Almería: TRFE-SI-2019/004, TRFE-SI-2022/010University of Almería: TRFE-BT-2019/002Ministry of Science, Innovation and Universities of the Government of Spain: FPU19/04608 and FPU20/05746Sede Provincial de Almería de la Asociación Española Contra el Cáncer and the AECC Scientific Foundation: PRDAM222381EST

The kinematics of the quadrupolar nebula M 1–75 and the identification of its central star

8 páginas, 5 figuras, 3 tablas.-- El Pdf del artículo es la versión pre-print: arXiv:1006.2398v1.-- et al.[Context]: The link between how bipolar planetary nebulae are shaped and their central stars is still poorly understood. [Aims]: This paper investigates the kinematics and shaping of the multipolar nebula M 1–75, and briefly discusses the location and nature of its central star. [Methods]: Fabry-Perot data from GHαFAS on the WHT that samples the Doppler shift of the [Nii] 658.3 nm line are used to study the dynamics of the nebula by means of a detailed 3D spatio-kinematical model. Multi-wavelength images and spectra from the WFC and IDS on the INT, as well as from ACAM on the WHT, allowed us to constrain the parameters of the central star. [Results]: The two pairs of lobes, angularly separated by ~22°, were ejected simultaneously approx. ~3500–5000 years ago, at the adopted distance range from 3.5 to 5.0 kpc. The larger lobes show a slight degree of point symmetry. The formation of the nebula could be explained by wind interaction in a system consisting of a post-AGB star surrounded by a disc warped by radiative instabilities. This requires the system to be a close binary or a single star that engulfed a planet as it died. On the other hand, we present broad- and narrow-band images and a low S/N optical spectrum of the highly-reddened, previously unnoticed star that is likely the nebular progenitor. Its estimated V–I colour allows us to derive a rough estimate of the parameters and nature of the central star.Peer reviewe

Respuestas de alimentación de Scolytus scolytus a extractos del floema de ramillas de olmo

Feeding responses by Scolytus scolytus were tested using elm twig bark extracts in a laboratory bioassay. One to 4- years-old elm twigs or small branches were sampled in spring and their bark extracted separately with methanol and with a mixture of petroleum ether and diethyl ether (1:1) as solvents. Bark extracts were tested in a two choice feeding bioassay consisting of two polyurethane discs placed in a 10 cm diameter Petri dish. Extracts were applied onto the discs and the amount of disc eaten by ten freshly emerged S. scolytus adults was recorded after 24 hours. Ten U. minor, two U. laevis, six U. glabra, three Dutch hybrids (European x Asiatic) and one U. pumila trees were tested in several comparisons. Discs with extracts from both U. laevis trees were significantly less eaten than those from U. pumila or from U. minor trees in two choice tests. Similarly, extracts from all U. glabra trees received less feeding than those from U. minor. On the contrary, S. scolytus showed no difference in feeding between U. pumila and U. minor extracts, and similarly for Dutch hybrids in comparison with two U. minor clones. Again, beetles preferred to feed on Dutch hybrid extracts better than in those from U. laevis. Significant intraspecific differences in feeding were obtained in U. minor. One of the U. minor clones resulted less chosen when compared to other four trees. Extracts from a dying U. minor tree received more feeding than those from a healthy tree. Comparisons were also made between bark extracts from 2-to 4-year-old vs. current-year twigs within the same trees. In one of the four U. minor tested, a significant preference for the older twig extracts was recorded.Se estudi&oacute; la respuesta de alimentaci&oacute;n de S. scolytus a extractos del floema de ramillas de olmo en bioensayos de laboratorio. Se muestrearon en primavera ramillas de olmo de uno a cuatro a&ntilde;os de edad y su floema fue extra&iacute;do independientemente con metanol o con una mezcla de eter de petr&oacute;leo y eter diet&iacute;lico (1:1). Los extractos del floema se evaluaron en un bioensayo de doble elecci&oacute;n consistente en dos discos de poliuretano dispuestos en una placa Petri de 10 cm de di&aacute;metro. Se aplicaron los extractos a los discos y se midi&oacute; la superficie de disco comida por diez adultos reci&eacute;n emergidos de S. scolytus durante 24 h. Se ensayaron diez U. minor, dos U. laevis, seis U. glabra, tres h&iacute;bridos holandeses (europeo x asi&aacute;tico) y un U. pumila en diversas comparaciones. Los discos con extractos de ambos U. laevis fueron significativamente menos comidos que aqu&eacute;llos con los de U. pumila o de U. minor. Igualmente, los extractos de todos los U. glabra recibieron menor alimentaci&oacute;n que aqu&eacute;llos de U. minor. Por el contrario, S. scolytus no mostr&oacute; preferencias entre los extractos de U. minor y de U. pumila, e igualmente, entre los de U. minor y los de h&iacute;bridos holandeses. Nuevamente, los escol&iacute;tidos prefirieron alimentarse menos de los extractos de U. laevis que de los h&iacute;bridos holandeses. Se encontraron diferencias intraespec&iacute;ficas significativas en U. minor. Uno de los clones de U. minor result&oacute; menos preferido cuando se le compar&oacute; con otros cuatro &aacute;rboles. Los extractos de un U. minor moribundo recibieron mayor alimentaci&oacute;n que los de un &aacute;rbol sano. Se realizaron comparaciones entre los extractos del floema de ramillas de 2 a 4 a&ntilde;os de edad y de ramillas del a&ntilde;o en curso de un mismo &aacute;rbol. En uno de cuatro U. minor ensayados se observ&oacute; una preferencia significativa por los extractos de las ramillas m&aacute;s viejas

El asentamiento romano de Catarroja : aproximación a su estudio

Tras la realización de trabajos previos de excavación y de estudio (aún en su fase previa) en laboratorio, se puede deducir que se han localizado y puesto parcialmente al descubierto los restos de una villa de época romana, con un amplio espectro cronológico (siglo ii, hasta al menos el siglo IV, con probable ocupación visigoda y tal vez árabe). Se trata de un establecimiento que une la función residencial a la productiva (la villa urbana y la villa rustica de los agrónomos latinos), ubicado en las cercanías del núcleo urbano de mayor importancia de la zona, Valentía. En este trabajo llevamos a cabo una aproximación, aún muy hipotética, al desarrollo de la vida en la villa, y a lo que pudo ser y representar, basándonos en los textos latinos y en los materiales arqueológicos. El área habitacional y de servicios se completa con un área funeraria, que también describimos.After the realization of previous works of excavation and study (yet in previous phase) in laboratory, is possible to infer the localization and put openly (partialy) the rests of an román villa with a large chronology spectre (second century until, at least, the fourth century with probable visigothic occupation and, maybe, arabian). It is an settement that link the residential function at the profitable one (the villa urbana and the villa rustica of the latín agronomists), located around near the civil nucleus of utmos importance of the zone. Valentía. Into the work we acomplish an aproximation, yet very hypothetic, at development of the Ufe in the villa and his representation, rest upon the latín texts and in the archaeologist materials. The habitational área and Services stay finished with an funeral área, which we also describe

Role of Tetraspanins CD9 and CD151 in Primary Melanocyte Motility

Tetraspanins CD9 and CD151 have been implicated in cellular motility and intercellular adhesion in several cellular types. Here, we have studied the subcellular localization and the functional role of these molecules in primary melanocytes. We found that endogenous tetraspanins preferentially clustered in areas of melanocyte homotypic intercellular contacts and at the tips of dendrites. These observations were further confirmed using time-lapse fluorescence confocal microscopy of melanocytes transfected with CD9– and CD151–GFP (green fluorescent protein) constructs, suggesting an involvement of these proteins in cellular contacts and migration. Cell adhesion and migration assays performed using blocking monoclonal antibodies against CD9 and CD151 showed no significant effect on cell–extracellular matrix adhesion, whereas the migration of melanocytes was significantly enhanced. The regulation of the migratory capacity of melanocytes by CD9 and CD151 was further confirmed knocking down the endogenous expression of these tetraspanins with small interference RNA oligonucleotides. Therefore, tetraspanin molecules are localized at motile structures in primary human melanocytes regulating the migratory capacity of these cells

Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: A systematic review

Introduction: Fibromyalgia (FM) is a prevalent disorder. However, few studies have evaluated the effect of treatment interventions on biomarker expression. The aim of this review was to explore the efficacy of non-pharmacological interventions on inflammatory biomarker expression, specifically cytokines, neuropeptides and C-reactive protein (CRP), in FM patients. Method: A literature search using PubMed, EMBASE, PsycINFO and the Cochrane library was performed from January 1990 to March 2015. Randomized controlled trials (RCTs) and non-RCTs published in English, French or Spanish were eligible. Results: Twelve articles with a total of 536 participants were included. After exercise, multidisciplinary, or dietary interventions in FM patients, interleukin (IL) expression appeared reduced, specifically serum IL-8 and IL-6 (spontaneous, lipopolysaccharide (LPS)-induced, or serum). Furthermore, the changes to insulin-like growth factor 1 (IGF-1) levels might indicate a beneficial role for fatigue in obese FM patients. In contrast, evidence of changes in neuropeptide and CRP levels seemed inconsistent. Conclusion: Despite minimal evidence, our findings indicate that exercise interventions might act as an anti-inflammatory treatment in FM patients and ameliorate inflammatory status, especially for pro-inflammatory cytokines. Additional RCTs focused on the changes to inflammatory biomarker expression after non-pharmacological interventions in FM patients are needed