Therapeutic Applications and Effects of Lupinus angustifolius (Blue Lupin) and Its Components: A Systematic Review and Meta-Analysis

Lupinus angustifolius has a unique nutrient profile among legumes and may have beneficial health effects when included in the diet. The aim of this study was to investigate the biological properties of blue lupin (Lupinus angustifolius), its chemical components, and their relevance for monitoring biological and anthropometric health markers, including triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), BMI, weight, and glycemia, compared with control groups with other kinds of diets. PubMed,Web of Science, and Scopus databases, updated to December 2023, were searched. Out of the 194 studies identified, a total of 7 randomized controlled trials (RCTs) comprising 302 participants met the eligibility criteria. The results of our study indicated that the blue lupin diet has a direct relationship with parameters such as blood glucose, weight, and LDL-C but not with TGs or BMI. In conclusion, the research described in this review clearly indicates that L. angustifolius may play an important role in the dietary prevention of hyperlipidemia and hypertension. Therefore, it would be highly advisable to increase its consumption in diets. However, further studies, ideally in humans, are required to truly establish L. angustifolius’s health-promoting properties

Beneficial effects of physical exercise on the osteo-renal Klotho-FGF-23 axis in Chronic Kidney Disease: A systematic review with meta-analysis

The aim of this study was to investigate the efficacy of physical exercise in chronic kidney disease, describing its impact on the Klotho-FGF23 axis. PubMed, Web of Science and Scopus databases, updated to January 2023, were searched. The present study employed mean difference and a 95% confidence interval (CI) to examine the efficacy of the intervention. Heterogeneity was assessed through inconsistency statistics (I2). Out of the 299 studies identified, a total of 4 randomized controlled trials (RCTs), comprising 272 participants, met the eligibility criteria. Compared with the control group, physical exercise significantly decreased the concentrations of FGF23 (MD: -102.07 Pg/mL, 95% CI: -176.23.47, -27.91 I2= 97%, p = 0.001), and a significantly increased the concentrations of Klotho protein: (MD: 158.82 Pg/mL, 95% CI: 123.33, -194.31, I2 = 0%, p = 0.001). The results of our study indicated that the exercise has a direct relationship with Klotho-FGF23 axis. We can conclude that physical exercise in patients with CKD produces beneficial effects on the pathophysiological components related to this disease, including cardiorespiratory fitness and vascular functions. As observed, both endurance and aerobic physical exercise increase Klotho production and decrease FGF23 levels. Evidence indicates that exercise attenuates the progression of CKD, improves uremic parameters and down-regulates inflammation-related markers

Flora y su funcionalidad en dos agroecosistemas de café (Coffea arabica L.) en Condega, Estelí, Nicaragua, 2016

Debido a los altos costos de manejo y contaminación en sistemas productivos convencional se da la necesidad de enfoques agroecológicos en la agricultura. El propósito de este estudio fue evaluar la flora y su funcionalidad en dos agro ecosistemas de café en la comunidad los Alpes, Condega departamento de Estelí.La finca Linda Vista está a una altitud de 1300 msnm y en la Finca El Milagro de Dios a 1100 msnm. Para la evaluación de la flora se dividieron las fincas en 5 estratos donde se estudió el bosque latifoliado con parcelas de 50 m*20 m y censo; para bosque latifoliado con árboles dispersos con franjas de 10 m de ancho con longitud variable. El muestreo de arvenses se realizó mediante el método del metro cuadrado de forma aleatoria y la flora cultivada por medio de un a entrevista semiestructurada. En la flora arvense se registró la abundancia y la diversidad, en los árboles se evaluaron variables dasométricas. Los organismos muestreados fueron identificados a nivel de clase, orden, familia, género y especie. El mayor porcentaje en las categorías de calidad de fustes, presencia de lianas y estado fitosanitario correspondieron a la Finca Linda Vista en las áreas boscosas y de árboles dispersos. El mayor porcentaje de intensidad de iluminación fue para la Finca El Milagro de Dios para árboles dispersos; para las áreas boscosas se destacó la Finca Linda Vista.Se identificaron 6 clases, 38 órdenes, 71 familias, 143 géneros y 155 especies. La Finca Linda Vista reflejó una mayor riqueza de especies en el índice alfa, en el índice de diversidad beta se encontraron disimilitudes en todas las categorías taxonómicas comunes. Prevalecieron los roles de árboles energéticos y de construcción sobresaliendo las familias Hamamedilaceae, Fabaceae, Pinaceae, Fagaceae y Vochysiaseace. En arvenses y cultivadas prevalecieron las medicinal y alimenticio por las familias Apiaceae, Commenlinaceae, Poaceae, Fabaceae, Solanaceae y Rubiaceae

Tumor de Krukemberg. Presentación de un caso

The case of an 18-year-old female patient who was admitted to the Oncology Department of the Celestino Hernández Robau University Hospital in Santa Clara, Villa Clara, is reported. The patient was diagnosed with an ovarian tumor requiring surgical treatment. The histopathologic diagnosis was adenocarcinoma with signet ring cells (Krukenberg tumor). The primary tumor was found in the colon. The frequency of Krukemberg tumor is 3-8% of ovarian tumors. It is more common in women between the fourth and fifth decades of life, and the most common location of the primary tumor is in the stomach. There are few studies on this disease despite its poor prognosis and rapid evolution.Se presenta el caso clínico de una joven de 18 años de edad que ingresa en el Servicio de Oncología del Hospital Universitario “Dr. Celestino Hernández Robau”, de Santa Clara, Villa Clara, con diagnóstico de tumor de ovario para tratamiento quirúrgico. El diagnóstico histopatológico fue de adenocarcinoma en anillo de sello (tumor de Krukenberg); el tumor primario se encontró en el colon. La frecuencia del  tumor de Krukemberg es del 3-8% de los tumores ováricos, generalmente lo padecen mujeres entre la cuarta y la quinta décadas de la vida y la localización más frecuente del tumor primario es, en primer lugar, el estómago. Existen pocos estudios acerca de esta enfermedad a pesar de su mal pronóstico y rápida evolución

Predicting First-Year College Student Retention: Validation of the College Persistence Questionnaire in a Spanish Sample

This paper analyzes the factorial and predictive validity of a Spanish adaptation of the College Persistence Questionnaire (SCPQ) on the retention of first year students (FYS) at university. The participants were 490 FYS from two public universities in Southern Europe (Spain). Factorial analysis of the SCPQ (chi(2)/gl = 1.66, CFI = 0.92, NNFI = 0.91, RMSEA = 0.04) showed six reliable dimensions, similar to those found in the original study: Academic Integration, Social Integration, Supportive Services Satisfaction, Academic Conscientiousness, Degree Commitment and Institutional Commitment. Logistic regression showed that institutional commitment significantly predicted FYS' permanence. The results support SCPQ's validity as an adequate and useful tool for assessing FYS' academic experiences involved in student retention.This research was partially funded by the University of Valencia, grant number SFPIE_DOCE12-79415

Study of weight and body mass index on graft loss after transplant over 5 years of evolution

Antonio Liñán González conceived paper, oversaw data collection, conducted data analysis, wrote manuscript and approved final version. Raquel García Pérez participated in study design, data analysis and interpretation, critically revised manuscript and approved final version. Juan Bravo Soto participated in study design, data analysis, and interpretation of data and revision of manuscript and approved final version. Rafael Fernández Castillo participated in study design, interpretation of data and revision of manuscript and approved final version.Patients frequently experience a weight gain after organ transplantation. This increase in weight is the result of multiple factors, and is usually intensified by glucocorticoids and immunosuppressive drugs. It can also delay graft function and cause serious health problems. The objective of this study was to study the obesity as well as its causes and consequences in kidney transplant patients. The sample population consisted of 282 renal transplant patients, 170 men and 112 women, 18-74 years of age, who were monitored over a period of five years. For the purposes of our research, the patients were divided into two groups: (1) normal weight 18.5 ≤ BMI <25; (2) overweight 25 ≤ BMI ≤30. The association between BMI as an independent variable and graft survival was determined by means of a Cox regression analysis. Overweight patients were characterized by a higher comorbidity prevalence. In the Cox multivariate analysis, the initial BMI, evaluated as a continuous variable continued to be an independent predictor of delayed graft function and chronic nephropathy. This study evaluated the BMI as a continuous value instead of a categorical value. In conclusion, our results suggest that an increase in BMI without categorical variation can be an independent risk factor for graft loss. Consequently, obesity prevention for renal transplant patients should include dietary counseling and management, moderate physical activity, and steroid minimization

Cuando se abandona y pasa en completo olvido la materia y objeto propio de una cuestion, y se recurre al ataque directo y esclusivo [sic] de las personas, se dá bastante á conocer, que por falta de razones, se ha querido usar del reprobado medio de la injuria ..

Se trata de la vindicación de Rafael Lorenzo García, miembro del comité del partido progresista, contra los ataques que se le hicieron por parte Cristóbal del Castillo, Rafael Massieu y otros miembros del partido moderado de Las Palmas, defensores de la candidatura de Bertran de LisLugar de imp. tomado de VicayaTexto fechado el 27 de noviembre de 185

A new striking and critically endangered species of Nasa (Loasaceae, Cornales) from North Peru

Nasa angeldiazioides sp. nov. is described and illustrated. The species is restricted to two forest remnants on the western slope of the northern Peruvian Andes (Dept. Lambayeque) where it is found in the undergrowth of primary forest. The new taxon shows a unique leaf morphology in the family Loasaceae. Molecular and morphological data show that the new species belongs to the Nasa triphylla group. Since the relic forests of the north-western Andes are increasingly threatened by the effects of climate change, i.e. droughts and wildfires, the new species already faces imminent extinction

Electron microscopy for inorganic-type drug delivery nanocarriers for antitumoral applications: What is possible to see?

The use of nanoparticles able to transport drugs, in a selective and controlable manner, directly to diseased tissues and cells have improved the therapeutic arsenal for addressing unmet clinical situations. In the recent years, a vast number of nanocarriers with inorganic, organic, hybrid and even biological nature have been developed, expecially for their application in oncology fied. The exponential growing in the nanomedicine field would not have been possible without the also rapid expansion of electron microscopy techniques, which allow a more precise observation of nanometric objects. The use of these techniques provides a better understanding of the key parameters which rule their synthesis and behavior. In this review, the recent advances performed in the application of inorganic nanoparticles for clinical uses and the role which has played electron microscopy will be presented