Vertex Reconstruction Using a Single Layer Silicon Detector

Typical vertex finding algorithms use reconstructed tracks, registered in a multi-layer detector, which directly point to the common point of origin. A detector with a single layer of silicon sensors registers the passage of primary particles only in one place. Nevertheless, the information available from these hits can also be used to estimate the vertex position, when the geometrical properties of silicon sensors and the measured ionization energy losses of the particles are fully exploited. In this paper the algorithm used for this purpose in the PHOBOS experiment is described. The vertex reconstruction performance is studied using simulations and compared with results obtained from real data. The very large acceptance of a single-layered multiplicity detector permits vertex reconstruction for low multiplicity events where other methods, using small acceptance subdetectors, fail because of insufficient number of registered primary tracks.Comment: accepted for publication in Nucl. Instr. Meth.

Cascading effects associated with climate-change-induced conifer mortality in mountain temperate forests result in hot-spots of soil CO 2 emissions

Climate change-induced tree mortality is occurring worldwide, at increasingly larger scales and with increasing frequency. How climate change-induced tree mortality could affect the ecology and carbon (C) sink capacity of soils remains unknown. This study investigated regional-scale drought-induced tree mortality, based on events that occurred after a very dry year (2012) in the Carpathians mountain range (Romania), which caused mortality in three common conifer species: Scots pine, Black pine, and Silver fir. This resulted in hot-spots of biogenic soil CO 2 emissions (soil respiration; Rs). Four to five years after the main mortality event, Rs-related soil CO 2 emissions under dead trees were, on average, 21% (ranging from 18 to 35%) higher than CO 2 emissions under living trees. Total (Rs) and heterotrophic (R H )-related soil CO 2 emissions were strongly related to alterations in the soil environment following tree mortality (e.g. changes in quantity and quality of soil organic matter, microclimate, pH or fine root demography). Moreover, the massive mortality event of 2012 resulted in greater presence of successional vegetation (broadleaf seedlings, shrubland and grasses), which may control the environmental factors that either directly or indirectly affected biotic soil fluxes (Rs and R H ). Besides the well-known direct effects of climate change on soil CO 2 emissions, the cascading effects triggered by climate change-induced tree mortality could also exert a strong indirect impact on soil CO 2 emissions. Overall, climate change-induced tree mortality alters the magnitude of environmental controls on Rs and hence determines how the ecosystem C budget responds to climate change. © 2019 Elsevier LtdThis work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) with the projects VERONICA ( CGL2013-42271-P ) and the project IBERYCA ( CGL2017-84723-P ), and by the Romanian Ministry of Education and Scientific Research through UEFISCDI with the projects TREEMORIS ( PN-II-RU-TE-2014-4-0791 ), NATIvE ( PN-III-P1-1.1-PD-2016-0583 ), and BIOCARB ( PN-III-P1-1.1-TE-2016-1508 ). This research was also supported by the Basque Government through the BERC 2018-2021 program, and by the Spanish Ministry of Economy and Competitiveness (MINECO) through the BC3 María de Maeztu excellence accreditation ( MDM-2017-0714 ). I.C. Petritan was partially funded by the H2020/ERA-NET/ERA-GAS (Project 82/2017, Mobilizing and monitoring climate positive efforts in forests and forestry, FORCLIMIT ). Many thanks to Cosmin Zgremtia, Ionela Medrea, Andrei Apafaian, Raluca Enescu and Marta Ramos for their valuable help during field campaigns and laboratory work

Asymptotic Giant Branch Variables in the Galaxy and the Local Group

AGB variables, particularly the large amplitude Mira type, are a vital step on the distance scale ladder. They will prove particularly important in the era of space telescopes and extremely large ground-based telescopes with adaptive optics, which will be optimized for infrared observing. Our current understanding of the distances to these stars is reviewed with particular emphasis on improvements that came from Hipparcos as well as on recent work on Local Group galaxies. In addition to providing the essential calibration for extragalactic distances Gaia may also provide unprecedented insight into the poorly understood mass-loss process itself.Comment: Accepted for publication in Astrophysics and Space Science. From a presentation at the conference "The Fundamental Cosmic Distance Scale: State of the Art and Gaia Perspective, Naples May 2011. 8 Pages, 9 Figure

Common bottlenose dolphins <i>Tursiops truncatus</i> of Pacific South America, asynoptic review of population identification data. Report of the IWC Scientific Committee Meeting SC/67A/SM/10, Bled, Slovenia, May 2017

We succinctly summarize population ID information for common bottlenose dolphins Tursiops truncatus of the Pacific coast of South America, covering four coastal range states. Phylogenetic uncertainties relate primarily to offshore vs. coastal (inshore) ecotypes and biogeographic borders between the five proposed populations (2 offshore, 3 coastal): Colombia-Ecuador Offshore stock (probably = ETP Offshore), Peru-Chile Offshore, Ecuador Coastal, Peru Coastal and an unique community (Pod-R) on the north-central coast of Chile. Main questions concern the extent of gene flow between the offshore stocks at one hand, and with -and between- the three coastal populations at the other hand. Seven cranial characters, four non-metric (separation of occipital condyles, pterygoid bone development, exostosis of periotic) and three metric (tooth width, antorbital process length, maximum width palatines), dorsal fin shape, body stockiness, mt-DNA (control region), habitat, prey composition, parasite load, behaviour and prevalence of some infectious diseases differentiate coastal from offshore forms. 'Pod-R' is the southernmost (29°15'S) and only confirmed coastal form community in Chilean waters, albeit with an offshore (falcate) dorsal fin. Bottlenose dolphins which regularly transit nearshore in the Lagos and Aysén regions (Chilean Patagonia) and occasionally enter deep fjords, present an offshore morphotype. We suggest that two other coastal areas in Chile where bottlenose dolphins have been documented over decades, one a ca. 60 km stretch of coastline centered at Valparaiso/Laguna Verde (33°10'S) in central Chile, and a 190 km coastline around the Mejillones Peninsula (23°10'S) in northern Chile, may not host coastal but offshore form animals. The continental border of the Atacama Trench off northern and northcentral Chile leaves an extremely narrow, steep shelf with nearshore deep water, locally with strong coastal upwelling and increased productivity. This habitat seems to attract oceanic cetaceans, including offshore T. truncatus, sperm whales, large balaenopterids, and other species. The southern distribution range of true coastal morphotype bottlenose dolphins in Pacific South America remains unknown but off Chile distance-to-shore may not be the reliable indicator of ecotype as it is further north in the study region

Is type of work associated with physical activity and sedentary behaviour in women with fibromyalgia A cross-sectional study from the al-Ándalus project

Objectives To analyse the association between the type of work (productive vs reproductive work) and the levels of physical activity and sedentary behaviour in women with fibromyalgia. Method This cross-sectional study involved 258 women with fibromyalgia from southern Spain. Of them, 55% performed reproductive work (unpaid, associated with caregiving and domestic roles) exclusively, while 45% had productive job (remunerated, that results in goods or services). Physical activity of light, moderate and vigorous intensity in the leisure time, at home, at work, and totally were measured through the leisure time physical activity instrument and with the physical activity at home and work instrument, respectively. Sedentary behaviour was measured by the Sedentary Behaviour Questionnaire. Results After adjusting for age, fat percentage, education level and marital status, the multivariate analysis of covariance model informed the existence of significant differences between type of work groups (p<0.001). Women with productive work engaged in more light physical activity at work (mean difference =448.52 min; 95 % CI 179.66 to 717.38; p=0.001), and total physical activity of light (809.72 min; 535.91 to 1085.53; p<0.001) and moderate (29

Evidence of Final-State Suppression of High-p_T Hadrons in Au + Au Collisions Using d + Au Measurements at RHIC

Transverse momentum spectra of charged hadrons with ${p_{T} <}$ 6 GeV/c have been measured near mid-rapidity (0.2 $< \eta <$ 1.4) by the PHOBOS experiment at RHIC in Au + Au and d + Au collisions at ${\sqrt{s_{_{NN}}} = \rm {200 GeV}}$. The spectra for different collision centralities are compared to ${p + \bar{p}}$ collisions at the same energy. The resulting nuclear modification factor for central Au + Au collisions shows evidence of strong suppression of charged hadrons in the high-$p_{T}$ region (${>2}$ GeV/c). In contrast, the d + Au nuclear modification factor exhibits no suppression of the high-$p_{T}$ yields. These measurements suggest a large energy loss of the high-$p_{T}$ particles in the highly interacting medium created in the central Au + Au collisions. The lack of suppression in d + Au collisions suggests that it is unlikely that initial state effects can explain the suppression in the central Au + Au collisions.Comment: 3 pages, 4 figures, International Europhysics Conference on High Energy Physics EPS (July 17th-23rd 2003) in Aachen, German

Small-molecule dual PLK1 and BRD4 inhibitors are active against preclinical models of pediatric solid tumors

Simultaneous inhibition of multiple molecular targets is an established strategy to improve the continuance of clinical response to therapy. Here, we screened 49 molecules with dual nanomolar inhibitory activity against BRD4 and PLK1, best classified as dual kinase-bromodomain inhibitors, in pediatric tumor cell lines for their antitumor activity. We identified two candidate dual kinase-bromodomain inhibitors with strong and tumor-specific activity against neuroblastoma, medulloblastoma, and rhabdomyosarcoma tumor cells. Dual PLK1 and BRD4 inhibitor treatment suppressed proliferation and induced apoptosis in pediatric tumor cell lines at low nanomolar concentrations. This was associated with reduced MYCN-driven gene expression as assessed by RNA sequencing. Treatment of patient-derived xenografts with dual inhibitor UMB103 led to significant tumor regression. We demonstrate that concurrent inhibition of two central regulators of MYC protein family of protooncogenes, BRD4, and PLK1, with single small molecules has strong and specific antitumor effects in preclinical pediatric cancer models

Identified particles in Au+Au collisions at sqrt{s_NN} = 200 GeV

The yields of identified particles have been measured at RHIC for Au+Au collisions at sqrt{s_NN} = 200 GeV using the PHOBOS spectrometer. The ratios of antiparticle to particle yields near mid-rapidity are presented. The first measurements of the invariant yields of charged pions, kaons and protons at very low transverse momenta are also shown.Comment: 4 pages, 4 figures, Contribution to Quark Matter 2002, Nantes, France, July 200

Recent Results from PHOBOS at RHIC

The PHOBOS experiment at RHIC has recorded measurements for Au-Au collisions spanning nucleon-nucleon center-of-mass energies from 19.6 GeV to 200 GeV. Global observables such as elliptic flow and charged particle multiplicity provide important constraints on model predictions that characterize the state of matter produced in these collisions. The nearly 4 pi acceptance of the PHOBOS experiment provides excellent coverage for complete flow and multiplicity measurements. Results including beam energy and centrality dependencies are presented and compared to elementary systems.Comment: 4 pages, 4 figures, proceedings from PANIC02 in Osaka, Japa

Global Observations from PHOBOS

Particle production in Au+Au collisions has been measured in the PHOBOS experiment at RHIC for a range of collision energies. Three empirical observations have emerged from this dataset which require theoretical examination. First, there is clear evidence of limiting fragmentation. Namely, particle production in central Au+Au collisions, when expressed as $dN/d\eta'$ ($\eta' \equiv \eta-y_{beam}$), becomes energy independent at high energy for a broad region of $\eta'$ around $\eta'=0$. This energy-independent region grows with energy, allowing only a limited region (if any) of longitudinal boost-invariance. Second, there is a striking similarity between particle production in e+e- and Au+Au collisions (scaled by the number of participating nucleon pairs). Both the total number of produced particles and the longitudinal distribution of produced particles are approximately the same in e+e- and in scaled Au+Au. This observation was not predicted and has not been explained. Finally, particle production has been found to scale approximately with the number of participating nucleon pairs for $N_{part}>65$. This scaling occurs both for the total multiplicity and for high \pT particles (3 <\pT< 4.5 GeV/c).Comment: QM2002 plenary talk, 10 pages, 11 figure