Are serial CA 19-9 kinetics helpful in predicting survival in patients with advanced or metastatic pancreatic cancer treated with gemcitabine and cisplatin?

Background: Serial kinetics of serum CA 19-9 levels have been reported to reflect response and survival in patients with pancreatic cancer undergoing surgery, radiotherapy, and chemotherapy. We prospectively studied serial kinetics of serum CA 19-9 levels of patients with locally advanced or metastatic disease treated with gemcitabine and cisplatin. Patients and Methods: Enrolled in the study were 87 patients (female/male = 26/61; stage III/IV disease = 24/63). Patients received gemcitabine 1,000 mg/m(2) on days 1, 8, and 15 plus cisplatin 50 mg/m(2) on days 1 and 15, every 4 weeks. Serum samples were collected at the onset of chemotherapy and before the start of a new treatment cycle (day 28). Results: 77 of 87 patients (88.5%) with initially elevated CA 19-9 levels were included for evaluation. According to imaging criteria, 4 (5.2%) achieved a complete remission and 11 (14.3%) achieved partial remission, yielding an overall response rate of 19.5%. 43 (55.8%) patients were CA 19-9 responders, defined by greater than or equal to50% decrease in CA 19-9 serum levels within 2 months after treatment initiation. Except for one, all patients who had responded by imaging criteria (n = 14) fulfilled the criterion of a CA 19-9 responder. Despite being characterized as non-responders by CT-imaging criteria (stable/progressive disease), 29 patients were classified as CA 19-9 responders (positive predictive value 32.5%). Independent of the response evaluation by CT, CA 19-9 responders survived significantly longer than CA 19-9 non-responders (295 d; 95% CI: 285-445 vs. 174 d; 95% CI: 134-198; p = 0.022). Conclusion: CA 19-9 kinetics in serum serve as an early and reliable indicator of response and help to predict survival in patients with advanced pancreatic cancer receiving effective treatment with gemcitabine and cisplatin

Unruh response functions for scalar fields in de Sitter space

We calculate the response functions of a freely falling Unruh detector in de Sitter space coupled to scalar fields of different coupling to the curvature, including the minimally coupled massless case. Although the responses differ strongly in the infrared as a consequence of the amplification of superhorizon modes, the energy levels of the detector are thermally populated.Comment: 16 pages, 1 figure, accepted for publication by Classical and Quantum Gravit

Right-handed Sneutrinos as Nonthermal Dark Matter

When the minimal supersymmetric standard model is augmented by three right-handed neutrino superfields, one generically predicts that the neutrinos acquire Majorana masses. We postulate that all supersymmetry (SUSY) breaking masses as well as the Majorana masses of the right-handed neutrinos are around the electroweak scale and, motivated by the smallness of neutrino masses, assume that the lightest supersymmetric particle (LSP) is an almost-pure right-handed sneutrino. We discuss the conditions under which this LSP is a successful dark matter candidate. In general, such an LSP has to be nonthermal in order not to overclose the universe, and we find the conditions under which this is indeed the case by comparing the Hubble expansion rate with the rates of the relevant thermalizing processes, including self-annihilation and co-annihilation with other SUSY and standard model particles.Comment: 17 pages v.2: References adde

Hybrid inflation followed by modular inflation

Inflationary models with a superheavy scale F-term hybrid inflation followed by an intermediate scale modular inflation are considered. The restrictions on the power spectrum P_R of curvature perturbation and the spectral index n_s from the recent data within the power-law cosmological model with cold dark matter and a cosmological constant can be met provided that the number of e-foldings N_HI* suffered by the pivot scale k_*=0.002/Mpc during hybrid inflation is suitably restricted. The additional e-foldings needed for solving the horizon and flatness problems are generated by modular inflation with a string axion as inflaton. For central values of P_R and n_s, the grand unification scale comes out, in the case of standard hybrid inflation, close to its supersymmetric value M_GUT=2.86 x 10^16 GeV, the relevant coupling constant is relatively large (0.005-0.14), and N_HI* is between 10 and 21.7. In the shifted [smooth] hybrid inflation case, the grand unification scale can be identified with M_GUT for N_HI*=21 [N_HI*=18].Comment: 13 pages including 3 figures, uses ws-ijmpa.cls, minor corrections included, talk given at the CTP Symposium on Supersymmetry at LHC: Theoretical and Experimental Perspectives, British University in Egypt (BUE), Cairo, 11-14 March 2007 (to appear in the proceedings

Resonant decay of flat directions

We study preheating, i.e., non-perturbative resonant decay, of flat direction fields, concentrating on MSSM flat directions and the right handed sneutrino. The difference between inflaton preheating and flaton preheating, is that the potential is more constraint in the latter case. The effects of a complex driving field, quartic couplings in the potential, and the presence of a thermal bath are important and cannot be neglected. Preheating of MSSM flat directions is typically delayed due to out-of-phase oscillations of the real and imaginary components and may be preceded by perturbative decay or $Q$-ball formation. Particle production due to the violation of adiabaticity is expected to be inefficient due to back reaction effects. For a small initial sneutrino VEV, $\lesssim m_N/h$ with $m_N$ the mass of the right handed sneutrino and $h$ a yakawa coupling, there are tachyonic instabilities. The $D$-term quartic couplings do not generate an effective mass for the tachyonic modes, making it an efficient decay channel. It is unclear how thermal scattering affects the resonance.Comment: 20 pages, 4 figure

Flavour-coherent propagators and Feynman rules: Covariant cQPA formulation

We present a simplified and generalized derivation of the flavour-coherent propagators and Feynman rules for the fermionic kinetic theory based on coherent quasiparticle approximation (cQPA). The new formulation immediately reveals the composite nature of the cQPA Wightman function as a product of two spectral functions and an effective two-point interaction vertex, which contains all quantum statistical and coherence information. We extend our previous work to the case of nonzero dispersive self-energy, which leads to a broader range of applications. By this scheme, we derive flavoured kinetic equations for local 2-point functions $S^{}_\mathbf{k}(t,t)$, which are reminiscent of the equations of motion for the density matrix. We emphasize that in our approach all the interaction terms are derived from first principles of nonequilibrium quantum field theory.Comment: 20 pages, 3 figures. Minor modifications, version published in JHE

Probing leptogenesis

The focus of this paper lies on the possible experimental tests of leptogenesis scenarios. We consider both leptogenesis generated from oscillations, as well as leptogenesis from out-of-equilibrium decays. As the Akhmedov-Rubakov-Smirnov (ARS) mechanism allows for heavy neutrinos in the GeV range, this opens up a plethora of possible experimental tests, e.g. at neutrino oscillation experiments, neutrinoless double beta decay, and direct searches for neutral heavy leptons at future facilities. In contrast, testing leptogenesis from out-of-equilibrium decays is a quite difficult task. We comment on the necessary conditions for having successful leptogenesis at the TeV-scale. We further discuss possible realizations and their model specific testability in extended seesaw models, models with extended gauge sectors, and supersymmetric leptogenesis. Not being able to test high-scale leptogenesis directly, we present a way to falsify such scenarios by focusing on their washout processes. This is discussed specifically for the left-right symmetric model and the observation of a heavy WR, as well as model independently when measuring L = 2 washout processes at the LHC or neutrinoless double beta decay.Fil: Chun, E. J.. Korea Institute For Advanced Study; Corea del SurFil: Cvetic, G.. Universidad Técnica Federico Santa María; ChileFil: Dev, P. S. B.. Washington University in St. Louis; Estados UnidosFil: Drewes, Alejandro Marcelo. Technische Universitat München; Alemania. Université Catholique de Louvain; BélgicaFil: Fong, C. S.. Universidade de Sao Paulo; BrasilFil: Garbrecht, B.. Technische Universitat München; AlemaniaFil: Hambye, T.. Université Libre de Bruxelles; BélgicaFil: Harz, J.. Institut Lagrange de Paris, Sorbonne Universitès; Francia. Centre National de la Recherche Scientifique; FranciaFil: Hernández, P.. Cern - European Organization For Nuclear Research; Suiza. Universidad de Valencia; EspañaFil: Kim, C. S.. Department Of Physics And Ipap, Yonsei University; Corea del SurFil: Molinaro, E.. University Of Southern Denmark; DinamarcaFil: Nardi, E.. Laboratori Nazionali Di Frascati; ItaliaFil: Racker, Juan Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Rius, N.. Universidad de Valencia; EspañaFil: Zamora-Saa, J.. Joint Institute For Nuclear Research; Rusi

Constraints on Brane Inflation and Cosmic Strings

By considering simple, but representative, models of brane inflation from a single brane-antibrane pair in the slow roll regime, we provide constraints on the parameters of the theory imposed by measurements of the CMB anisotropies by WMAP including a cosmic string component. We find that inclusion of the string component is critical in constraining parameters. In the most general model studied, which includes an inflaton mass term, as well as the brane-antibrane attraction, values n_s < 1.02 are compatible with the data at 95 % confidence level. We are also able to constrain the volume of internal manifold (modulo factors dependent on the warp factor) and the value of the inflaton field to be less than 0.66M_P at horizon exit. We also investigate models with a mass term. These observational considerations suggest that such models have r < 2*10^-5, which can only be circumvented in the fast roll regime, or by increasing the number of antibranes. Such a value of r would not be detectable in CMB polarization experiment likely in the near future, but the B-mode signal from the cosmic strings could be detectable. We present forecasts of what a similar analysis using PLANCK data would yield and find that it should be possible to rule out G\mu > 6.5*10^-8 using just the TT, TE and EE power spectra.Comment: 11 pages, 3 figures, revtex4, typos corrected, references adde

Thermal production of relativistic Majorana neutrinos: Strong enhancement by multiple soft scattering

The production rate of heavy Majorana neutrinos is relevant for models of thermal leptogenesis in the early Universe. In the high temperature limit the production can proceed via the 1 2 (inverse) decays which are allowed by the thermal masses. We consider new production mechanisms which are obtained by including additional soft gauge interactions with the plasma. We show that an arbitrary number of such interactions gives leading order contributions, and we sum all of them. The rate turns out to be smooth in the region where the 1 2 processes are kinematically forbidden. At higher temperature it is enhanced by a factor 3 compared to the 1 2 rate.Comment: 26 pages, 8 figures; added references, added comments on 2 to 2 scattering processes, improved appearance of fig. 8, corrected typos; matches published versio

The Minimal Scale Invariant Extension of the Standard Model

We perform a systematic analysis of an extension of the Standard Model that includes a complex singlet scalar field and is scale invariant at the tree level. We call such a model the Minimal Scale Invariant extension of the Standard Model (MSISM). The tree-level scale invariance of the model is explicitly broken by quantum corrections, which can trigger electroweak symmetry breaking and potentially provide a mechanism for solving the gauge hierarchy problem. Even though the scale invariant Standard Model is not a realistic scenario, the addition of a complex singlet scalar field may result in a perturbative and phenomenologically viable theory. We present a complete classification of the flat directions which may occur in the classical scalar potential of the MSISM. After calculating the one-loop effective potential of the MSISM, we investigate a number of representative scenarios and determine their scalar boson mass spectra, as well as their perturbatively allowed parameter space compatible with electroweak precision data. We discuss the phenomenological implications of these scenarios, in particular, whether they realize explicit or spontaneous CP violation, neutrino masses or provide dark matter candidates. In particular, we find a new minimal scale-invariant model of maximal spontaneous CP violation which can stay perturbative up to Planck-mass energy scales, without introducing an unnaturally large hierarchy in the scalar-potential couplings.Comment: 71 pages, 34 eps figures, numerical error corrected, clarifying comments adde