521 research outputs found
Prognostic impact of coronary microcirculation abnormalities in systemic sclerosis: a prospective study to evaluate the role of non-invasive tests
INTRODUCTION: Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combining two functional tests in SSc patients and estimating its impact on disease outcome.
METHODS: Forty-one SSc patients, asymptomatic for coronary artery disease, were tested for coronary flow velocity reserve (CFR) by transthoracic-echo-Doppler with adenosine infusion (A-TTE) and for left ventricular wall motion abnormalities (WMA) by dobutamine stress echocardiography (DSE). Myocardial multi-detector computed tomography (MDCT) enabled the presence of epicardial stenosis, which could interfere with the accuracy of the tests, to be excluded. Patient survival rate was assessed over a 6.7- ± 3.5-year follow-up.
RESULTS: Nineteen out of 41 (46%) SSc patients had a reduced CFR (≤2.5) and in 16/41 (39%) a WMA was observed during DSE. Furthermore, 13/41 (32%) patients showed pathological CFR and WMA. An inverse correlation between wall motion score index (WMSI) during DSE and CFR value (r = -0.57, P <0.0001) was observed; in addition, CFR was significantly reduced (2.21 ± 0.38) in patients with WMA as compared to those without (2.94 ± 0.60) (P <0.0001). In 12 patients with abnormal DSE, MDCT was used to exclude macrovasculopathy. During a 6.7- ± 3.5-year follow-up seven patients with abnormal coronary functional tests died of disease-related causes, compared to only one patient with normal tests.
CONCLUSIONS: A-TTE and DSE tests are useful tools to detect non-invasively pre-clinical microcirculation abnormalities in SSc patients; moreover, abnormal CFR and WMA might be related to a worse disease outcome suggesting a prognostic value of these tests, similar to other myocardial diseases
COLD HEAD MONITOR: Monitoraggio delle teste fredde
In un sistema di raffreddamento per ricevitori radioastronomici, la corretta manutenzione delle criopompe e dei compressori è fondamentale per il mantenimento delle prestazioni nel tempo.
Lo scopo di questo progetto è quello di monitorare le correnti di alimentazione del motore della testa fredda: le parti meccaniche che lo compongono sono soggette ad usura e possono compromettere il funzionamento dell’intero sistema. Eventuali anomalie nelle correnti possono infatti permettere di prevedere in anticipo eventuali malfunzionamenti riducendo i tempi di inattività non programmati
Classificazione delle Modulazioni Radio tramite Deep Learning per applicazioni radioastronomiche
Nel presente report viene illustrato un progetto di ricerca per il rilevamento e la classificazione
delle Radio Frequency Interference (RFI) utilizzando algoritmi di machine learning con l’obiettivo
di sviluppare un sistema automatizzato in grado di identificare e analizzare segnali indesiderati
in modo rapido ed efficiente. La classificazione accurata delle RFI è fondamentale per mitigare le
interferenze durante le osservazioni scientifiche con il Sardinia Radio Telescope (SRT).
Nel corso del progetto, sono stati raccolti dati relativi alle interferenze RFI in parte da dataset
online e in parte utilizzando strumenti di acquisizione. Sono state esplorate diverse architetture
di reti neurali e ne sono state valutate le performance utilizzando misure come l’accuratezza, la
perdita (loss) e la matrice di confusione.
Sono state utilizzate anche apparecchiature hardware ad alta fedeltà per confrontare e valutare
le prestazioni dei modelli di intelligenza artificiale sviluppati. Questo confronto è stato fondamentale
per garantire l’accuratezza dei modelli e consentire una valutazione comparativa con gli strumenti
hardware considerati come punto di riferimento
Characterization of the molecular dysfunctions occurring in Aicardi-Goutières syndrome patients with mutations in ADAR1
Multiple Septic Bursitis and Spontaneous Achilles Tendon Tear in Systemic Lupus Erythematosus
Intrinsic time resolution of 3D-trench silicon pixels for charged particle detection
In the last years, high-resolution time tagging has emerged as the tool to
tackle the problem of high-track density in the detectors of the next
generation of experiments at particle colliders. Time resolutions below 50ps
and event average repetition rates of tens of MHz on sensor pixels having a
pitch of 50m are typical minimum requirements. This poses an important
scientific and technological challenge on the development of particle sensors
and processing electronics. The TIMESPOT initiative (which stands for TIME and
SPace real-time Operating Tracker) aims at the development of a full prototype
detection system suitable for the particle trackers of the next-to-come
particle physics experiments. This paper describes the results obtained on the
first batch of TIMESPOT silicon sensors, based on a novel 3D MEMS (micro
electro-mechanical systems) design. Following this approach, the performance of
other ongoing silicon sensor developments has been matched and overcome, while
using a technology which is known to be robust against radiation degradation. A
time resolution of the order of 20ps has been measured at room temperature
suggesting also possible improvements after further optimisations of the
front-end electronics processing stage.Comment: This version was accepted to be published on JINST on 21/07/202
Fabrication and Characterisation of 3D Diamond Pixel Detectors With Timing Capabilities
Diamond sensors provide a promising radiation hard solution to the challenges posed by the future experiments at hadron machines. A 3D geometry with thin columnar resistive electrodes orthogonal to the diamond surface, obtained by laser nanofabrication, is expected to provide significantly better time resolution with respect to the extensively studied planar diamond sensors. We report on the development, production, and characterisation of innovative 3D diamond sensors achieving 30% improvement in both space and time resolution with respect to sensors from the previous generation. This is the first complete characterisation of the time resolution of 3D diamond sensors and combines results from tests with laser, beta rays and high energy particle beams. Plans and strategies for further improvement in the fabrication technology and readout systems are also discussed
The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09
Objectives. HLA-B*27:05 is associated with AS whereas HLA-B*27:09 is not associated. We hypothesized that different interactions with KIR immune receptors could contribute to the difference in disease association between HLA-B*27:05 and HLAB*27:09. Thus, the objective of this study was to compare the formation of β2m-free heavy chain (FHC) including B27 dimers (B272) by HLA-B*27:05 and HLA-B*27:09 and their binding to KIR immunoreceptors. Methods. We studied the formation of HLA-B*27:05 and HLA-B*27:09 heterotrimers and FHC forms including dimers in vitro and in transfected cells. We investigated HLA-B*27:05 and HLA-B*27:09 binding to KIR3DL1, KIR3DL2 and LILRB2 by FACS staining with class I tetramers and by quantifying interactions with KIR3DL2CD3ε-reporter cells and KIR3DL2-expressing NK cells. We also measured KIR expression on peripheral blood NK and CD4 T cells from 18 HLA-B*27:05 AS patients, 8 HLA-B27 negative and 12 HLA-B*27:05+ and HLA-B*27:09+ healthy controls by FACS staining. Results. HLA-B*27:09 formed less B272 and FHC than HLA-B*27:05. HLA-B*27:05-expressing cells stimulated KIR3DL2CD3ε-reporter T cells more effectively. Cells expressing HLA-B*27:05 promoted KIR3DL2+ NK cell survival more strongly than HLA-B*27:09. HLA-B*27:05 and HLA-B*27:09 dimer tetramers stained KIR3DL1, KIR3DL2 and LILRB2 equivalently. Increased proportions of NK and CD4 T cells expressed KIR3DL2 in HLA-B*27:05+ AS patients compared with HLA-B*27:05+, HLA-B*27:09+ and HLA-B27− healthy controls. Conclusion. Differences in the formation of FHC ligands for KIR3DL2 by HLA-B*27:05 and HLA-B*27:09 could contribute to the differential association of these alleles with A
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
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