Development of CO2 snow cleaning for in situ cleaning of µCMM stylus tips

Contamination adhered to the surface of a µCMM stylus tip compromises the measurement accuracy of the µCMM system, potentially causing dimensional errors that are over ten times larger than the uncertainty of a modern µCMM. In prior work by the authors, the use of a high pressure CO2 gas stream was demonstrated to achieve significant cleaning rate for a range of contaminant without damage to the stylus tip surface. This paper explores the practical challenges of achieving effective stylus tip cleaning in situ on µCMM systems. Two types of snow cleaning approaches were evaluated for their coverage of cleaning, thermal impact and gas flow forces. This work then presents a novel multi-nozzle prototype system using pulsed snow streams to achieve cleaning coverage over the entire stylus tip, and balances forces from the snow streams reducing drag force imparted by the gas stream to levels comparable to the probing force of µCMMs, as well as allowing automated cleaning procedure integrated into a µCMM system

Regulation of rat intrapulmonary arterial tone by arachidonic acid and prostaglandin E2 during hypoxia

Aims Arachidonic acid (AA) and its metabolites, prostaglandins (PG) are known to be involved in regulation of vascular homeostasis including vascular tone and vessel wall tension, but their potential role in Hypoxic pulmonary vasoconstriction (HPV) remains unclear. In this study, we examined the effects of AA and PGE2 on the hypoxic response in isolated rat intrapulmonary arteries (IPAs). Methods and Results We carried out the investigation on IPAs by vessel tension measurement. Isotetrandrine (20 µM) significantly inhibited phase I, phase IIb and phase IIc of hypoxic vasoconstriction. Both indomethacin (100 µM) and NS398 attenuated KPSS-induced vessel contraction and phase I, phase IIb and phase IIc of HPV, implying that COX-2 plays a primary role in the hypoxic response of rat IPAs. PGE2 alone caused a significant vasoconstriction in isolated rat IPAs. This constriction is mediated by EP4. Blockage of EP4 by L-161982 (1 µM) significantly inhibited phase I, phase IIb and phase IIc of hypoxic vasoconstriction. However, AH6809 (3 µM), an antagonist of EP1, EP2, EP3 and DP1 receptors, exerted no effect on KPSS or hypoxia induced vessel contraction. Increase of cellular cAMP by forskolin could significantly reduce KPSS-induced vessel contraction and abolish phase I, phase II b and phase II c of HPV. Conclusion Our results demonstrated a vasoconstrictive effect of PGE2 on rat IPAs and this effect is via activation of EP4. Furthermore, our results suggest that intracellular cAMP plays dual roles in regulation of vascular tone, depending on the spatial distribution of cAMP and its coupling with EP receptor and Ca2+ channels

High-Performance NiS₂ Hollow Nanosphere Cathodes in Magnesium-Ion Batteries Enabled by Tunable Redox Chemistry

Two-dimensional metal dichalcogenides have demonstrated outstanding potential as cathodes for magnesium-ion batteries. However, the limited capacity, poor cycling stability, and severe electrode pulverization, resulting from lack of void space for expansion, impede their further development. In this work, we report for the first time, nickel sulfide (NiS2) hollow nanospheres assembled with nanoparticles for use as cathode materials in magnesium-ion batteries. Notably, the nanospheres were prepared by a one-step solvothermal process in the absence of an additive. The results show that regulating the synergistic effect between the rich anions and hollow structure positively affects its electrochemical performance. Crystallographic and microstructural characterizations reveal the reversible anionic redox of S2–/(S2)2–, consistent with density functional theory results. Consequently, the optimized cathode (8-NiS2 hollow nanospheres) could deliver a large capacity of 301 mA h g–1 after 100 cycles at 50 mA g–1, supporting the promising practical application of NiS2 hollow nanospheres in magnesium-ion batteries