240 research outputs found

    Intermittent Prediction Method Based On Marcov Method And Grey Prediction Method

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    This paper concentrates on the intermittent demand for electric power supply and studies the method of demand prediction. This chapter first divides the demand for electric power supply into two statistical sequences: (1) sequence of demand occurrence, among which “1”stands for the occurrence of demand,“0”means that the demand fails to occur; (2) sequence of demand quantity. Next the author predicts the moment of time and the number of times n that demand occurs within a specific time interval in the future based on 0-1 sequence using Markov arrival process (MAP). Then the paper forecasts the demand quantity in subsequent n intervals using Grey prediction model GM (1, 1) based on the sequence of demand quantity. Finally, the author places the demand quantity in the n intervals in order at the moments where demand occurs to get the predicted result of demand for electric material with intermittent demand. According to instance analysis, the integrated approach mentioned in this paper surpasses existing methods in providing accurate prediction on data of product with intermittent demand

    The Effects of the Correlation of Electric Materials on Forecasting and Stock Control

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    Forecasting and stock control play an important role in the electric companies because outstanding forecasting and stock control increase service level obviously and decrease stock cost effectively. However, the majority of the electric materials are intermittent demand, resulting in poor forecasting and stock control performance. Therefore, exploring the reasons that affect forecasting performance and stock control is necessary. This paper explores the effects of the correlation of intermittent electric materials on forecasting and stock control. First, we divide the correlation into three categories: autocorrelation in demand sizes, autocorrelation in intervals and cross-correlation between demand size and interval. Forecasting by SBA approach and using periodic dynamic inventory strategy (T, S) to control stock, exploring the effects of these three correlations on forecast accuracy, stock cost and service level. The data shows that correlations of electric materials affect their forecasting and stock control, which will help company find more accurate forecast approach and lower the cost of stock in the future

    Network-Based Gene Expression Biomarkers for Cold and Heat Patterns of Rheumatoid Arthritis in Traditional Chinese Medicine

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    In Traditional Chinese Medicine (TCM), patients with Rheumatoid Arthritis (RA) can be classified into two main patterns: cold-pattern and heat-pattern. This paper identified the network-based gene expression biomarkers for both cold- and heat-patterns of RA. Gene expression profilings of CD4+ T cells from cold-pattern RA patients, heat-pattern RA patients, and healthy volunteers were obtained using microarray. The differentially expressed genes and related networks were explored using DAVID, GeneSpring software, and the protein-protein interactions (PPI) method. EIF4A2, CCNT1, and IL7R, which were related to the up-regulation of cell proliferation and the Jak-STAT cascade, were significant gene biomarkers of the TCM cold pattern of RA. PRKAA1, HSPA8, and LSM6, which were related to fatty acid metabolism and the I-κB kinase/NF-κB cascade, were significant biomarkers of the TCM heat-pattern of RA. The network-based gene expression biomarkers for the TCM cold- and heat-patterns may be helpful for the further stratification of RA patients when deciding on interventions or clinical trials

    Effects of acute exercise fatigue on the spatiotemporal dynamics of resting-state large-scale brain networks

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    IntroductionVarious approaches have been used to explore different aspects of the regulation of brain activity by acute exercise, but few studies have been conducted on the effects of acute exercise fatigue on large-scale brain functional networks. Therefore, the present study aimed to explore the effects of acute exercise fatigue on resting-state electroencephalogram (EEG) microstates and large-scale brain network rhythm energy.MethodsThe Bruce protocol was used as the experimental exercise model with a self-controlled experimental design. Thirty males performed incremental load exercise tests on treadmill until exhaustion. EEG signal acquisition was completed before and after exercise. EEG microstates and resting-state cortical rhythm techniques were used to analyze the EEG signal.ResultsThe microstate results showed that the duration, occurrence, and contribution of Microstate C were significantly higher after exhaustive exercise (p’s < 0.01). There was a significantly lower contribution of Microstate D (p < 0.05), a significant increase in transition probabilities between Microstate A and C (p < 0.05), and a significant decrease in transition probabilities between Microstate B and D (p < 0.05). The results of EEG rhythm energy on the large-scale brain network showed that the energy in the high-frequency β band was significantly higher in the visual network (p < 0.05).DiscussionOur results suggest that frequently Microstate C associated with the convexity network are important for the organism to respond to internal and external information stimuli and thus regulate motor behavior in time to protect organism integrity. The decreases in Microstate D parameters, associated with the attentional network, are an important neural mechanism explaining the decrease in attention-related cognitive or behavioral performance due to acute exercise fatigue. The high energy in the high-frequency β band on the visual network can be explained in the sense of the neural efficiency hypothesis, which indicates a decrease in neural efficiency

    The genome evolution and domestication of tropical fruit mango

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    Background: Mango is one of the world’s most important tropical fruits. It belongs to the family Anacardiaceae, which includes several other economically important species, notably cashew, sumac and pistachio from other genera. Many species in this family produce family-specific urushiols and related phenols, which can induce contact dermatitis. Results: We generate a chromosome-scale genome assembly of mango, providing a reference genome for the Anacardiaceae family. Our results indicate the occurrence of a recent whole-genome duplication (WGD) event in mango. Duplicated genes preferentially retained include photosynthetic, photorespiration, and lipid metabolic genes that may have provided adaptive advantages to sharp historical decreases in atmospheric carbon dioxide and global temperatures. A notable example of an extended gene family is the chalcone synthase (CHS) family of genes, and particular genes in this family show universally higher expression in peels than in flesh, likely for the biosynthesis of urushiols and related phenols. Genome resequencing reveals two distinct groups of mango varieties, with commercial varieties clustered with India germplasms and demonstrating allelic admixture, and indigenous varieties from Southeast Asia in the second group. Landraces indigenous in China formed distinct clades, and some showed admixture in genomes. Conclusions: Analysis of chromosome-scale mango genome sequences reveals photosynthesis and lipid metabolism are preferentially retained after a recent WGD event, and expansion of CHS genes is likely associated with urushiol biosynthesis in mango. Genome resequencing clarifies two groups of mango varieties, discovers allelic admixture in commercial varieties, and shows distinct genetic background of landraces

    Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China

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    Initial genetic characterizations have suggested that the influenza A (H7N9) viruses responsible for the current outbreak in China are novel reassortants. However, little is known about the pathways of their evolution and, in particular, the generation of diverse viral genotypes. Here we report an in-depth evolutionary analysis of whole-genome sequence data of 45 H7N9 and 42 H9N2 viruses isolated from humans, poultry, and wild birds during recent influenza surveillance efforts in China. Our analysis shows that the H7N9 viruses were generated by at least two steps of sequential reassortments involving distinct H9N2 donor viruses in different hosts. The first reassortment likely occurred in wild birds and the second in domestic birds in east China in early 2012. Our study identifies the pathways for the generation of diverse H7N9 genotypes in China and highlights the importance of monitoring multiple sources for effective surveillance of potential influenza outbreaks.National Natural Science Foundation (China) (31125016)National Natural Science Foundation (China) (31371338)National Center for Biotechnology Information (U.S.) (Major National Earmark Project for Infectious Diseases, 2013ZX10004611-002)National Basic Research Program of China (973 Program)National Basic Research Program of China (973 Program, grant, 2009CB918503)National Science and Technology Major Projects (2012ZX10004214001002)Jiangsu Sheng (China) (Priority Academic Program Development of Jiangsu Higher Education Institutions)National Natural Science Foundation (China) (31100950)MIT International Science and Technology Initiative

    Encode and Permute that Database! Single-Server Private Information Retrieval with Constant Online Time, Communication, and Client-Side Storage

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    Private Information Retrieval (PIR) facilitates the retrieval of database entries by a client from a remote server without revealing which specific entry is being queried. The preprocessing model has emerged as a significant technique for constructing efficient PIR systems, allowing parties to execute a one-time, query-independent offline phase, and then a fast online retrieval phase. In particular, Corrigan-Gibbs and Kogan (EUROCRYPT 2020) presented a new framework for constructing PIR with sublinear online time. Nevertheless, their protocol is deemed impractical in the single-server setting due to the heavy use of Fully Homomorphic Encryption (FHE). More recently, two state-of-the-art (SOTA) single-server PIR protocols (Zhou et al., S&P 2024 and Mughees-Ren, ePrint 2023) have eliminated FHE, at the price of linear offline communication. However, the client-side storage is still relatively large (O~(n)\tilde{O}(\sqrt{n})), which poses challenges to practical deployment, especially when the client has limited computation and storage capabilities. To address such limitation, we propose a novel PIR protocol Pai, which only requires constant online time, communication, and client-side storage. The price we pay is only a 11 - 5×5\times increase in offline communication, which would be acceptable since it is a one-time cost.Building upon our Pai, we also present a Symmetric KPIR (KSPIR) PaiKSPIR and a Chargeable KSPIR (CKSPIR) PaiCKSPIR. These two variants of PIR offer enhanced functionalities while maintaining computational complexities similar to the original Pai. In addition to providing rigorous theoretical proofs of correctness and privacy for Pai, we have undertaken comprehensive protocol implementations and conducted extensive experiments to validate their high efficiency. Our empirical findings demonstrate that our protocols achieve notably higher online efficiency than SOTA protocols, e.g., Pai exhibits 8.88.8 - 91.8×91.8\times better online communication cost and 2.52.5 - 8.8×8.8\times better online time. Given the superior online time and storage, our protocol is well-suited for practical deployment

    The genome evolution and domestication of tropical fruit mango

    Get PDF
    Background: Mango is one of the world’s most important tropical fruits. It belongs to the family Anacardiaceae, which includes several other economically important species, notably cashew, sumac and pistachio from other genera. Many species in this family produce family-specific urushiols and related phenols, which can induce contact dermatitis. Results: We generate a chromosome-scale genome assembly of mango, providing a reference genome for the Anacardiaceae family. Our results indicate the occurrence of a recent whole-genome duplication (WGD) event in mango. Duplicated genes preferentially retained include photosynthetic, photorespiration, and lipid metabolic genes that may have provided adaptive advantages to sharp historical decreases in atmospheric carbon dioxide and global temperatures. A notable example of an extended gene family is the chalcone synthase (CHS) family of genes, and particular genes in this family show universally higher expression in peels than in flesh, likely for the biosynthesis of urushiols and related phenols. Genome resequencing reveals two distinct groups of mango varieties, with commercial varieties clustered with India germplasms and demonstrating allelic admixture, and indigenous varieties from Southeast Asia in the second group. Landraces indigenous in China formed distinct clades, and some showed admixture in genomes. Conclusions: Analysis of chromosome-scale mango genome sequences reveals photosynthesis and lipid metabolism are preferentially retained after a recent WGD event, and expansion of CHS genes is likely associated with urushiol biosynthesis in mango. Genome resequencing clarifies two groups of mango varieties, discovers allelic admixture in commercial varieties, and shows distinct genetic background of landraces
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