Pre-Insolvency Proceedings: A Normative Foundation and Framework, by Nicolaes Tollenaar

Book Review: Pre-Insolvency Proceedings: A Normative Foundation and Framework By Nicolaes Tollenaa

JCOERE Consortium. Report 1: Identifying substantive and procedural rules in preventive restructuring frameworks including the Preventive Restructuring Directive which may be incompatible with judicial co-operation obligations

Judicial Co-operation Supporting Economic Recovery in Europe (JCOERE).This report provides a comprehensive analysis of the nature of substantive and procedural aspects that may arise in complex preventive restructuring or rescue regimes as envisaged by the Preventive Restructuring Directive (2019/1023). The report includes a comparative analysis of eleven European Member State jurisdictions, considering their pre-existing systems and approaches, and their responses taken to the Preventive Restructuring Directive

Judicial Co-Operation in Economic Recovery (JCOERE)

Irene Lynch Fannon and Jennifer L. L. Gant provide an update on INSOL Europe’s involvement in the new EU-funded project

JCOERE - Judicial Cooperation in the European Union: Insolvency and Rescue

In this conference paper, the JCOERE project consider some implications connected to the Preventive Restructuring Directive and the cooperation obligations under the EIR Recast against the backdrop of emerging European debates. The paper then goes on to consider how the PRD reflects a range of preventive restructuring processes that already exist in the EU with a particular focus on the Irish Examinership process

Special Report: Judicial Co-Operation in the European Union: Insolvency and Rescue

Judicial Co-Operation for Economic Recovery in Europe (JCOERE) is a research action project funded by the EU Commission DG Justice. JCOERE focuses on substantive and procedural rules typical to restructuring frameworks that are likely to present obstacles to court co-operation as mandated by the European Insolvency Regulation Recast. In its first Report (JCOERE 1) the Project surveys a range of rescue frameworks in European jurisdictions, benchmarked against core concepts in the Preventive Restructuring Directive. In its second phase, engaging proactively with national EU judiciary, JCOERE will document experiences with co-operation including utilisation of co-operation guidelines. It will disseminate its findings to support co-operation in corporate rescue. This report summarises the first steps and some of the preliminary findings that are fully described in JCOERE Report 1

JCOERE Consortium. Report 2: Report on Judicial Co-operation in Preventive Restructuring and Insolvency in the EU – Substantive and procedural harmonisation, judicial practice and guidelines

Judicial Co-operation Supporting Economic Recovery in Europe (JCOERE)The second JCOERE Report analyses the co-operation obligations arising from the EIR Recast, which are imposed on courts and practitioners in EU Member States to co-operate in cross-border insolvency and restructuring matters. This Report undertakes a benchmarking of judicial utilisation and awareness of best practice guidelines for co-operation in cross-border insolvency and preventive restructuring cases that have been adopted by European and international organisations. Report 2 also considers broader questions, such as differences in judicial culture across the EU Member States, how this impacts mutual trust and effective cooperation, and how the obligations and broader initiatives concerning judicial co-operation are fundamental to the question of European integration and harmonisation. A comparative analysis of judicial co-operation in another federalised jurisdiction has also been undertaken in this report, between the European Union and the United States

Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer\u27s Disease

Astrocytes are the most abundant cell type in the brain and play a critical role in maintaining healthy nervous tissue. In Alzheimer\u27s disease (AD) and most other neurodegenerative disorders, many astrocytes convert to a chronically activated phenotype characterized by morphologic and biochemical changes that appear to compromise protective properties and/or promote harmful neuroinflammatory processes. Activated astrocytes emerge early in the course of AD and become increasingly prominent as clinical and pathological symptoms progress, but few studies have tested the potential of astrocyte-targeted therapeutics in an intact animal model of AD. Here, we used adeno-associated virus (AAV) vectors containing the astrocyte-specific Gfa2 promoter to target hippocampal astrocytes in APP/PS1 mice. AAV-Gfa2 vectors drove the expression of VIVIT, a peptide that interferes with the immune/inflammatory calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway, shown by our laboratory and others to orchestrate biochemical cascades leading to astrocyte activation. After several months of treatment with Gfa2-VIVIT, APP/PS1 mice exhibited improved cognitive and synaptic function, reduced glial activation, and lower amyloid levels. The results confirm a deleterious role for activated astrocytes in AD and lay the groundwork for exploration of other novel astrocyte-based therapies

Inhibition of Soluble Tumor Necrosis Factor Ameliorates Synaptic Alterations and Ca2+ Dysregulation in Aged Rats

The role of tumor necrosis factor α (TNF) in neural function has been investigated extensively in several neurodegenerative conditions, but rarely in brain aging, where cognitive and physiologic changes are milder and more variable. Here, we show that protein levels for TNF receptor 1 (TNFR1) are significantly elevated in the hippocampus relative to TNF receptor 2 (TNFR2) in aged (22 months) but not young adult (6 months) Fischer 344 rats. To determine if altered TNF/TNFR1 interactions contribute to key brain aging biomarkers, aged rats received chronic (4–6 week) intracranial infusions of XPro1595: a soluble dominant negative TNF that preferentially inhibits TNFR1 signaling. Aged rats treated with XPro1595 showed improved Morris Water Maze performance, reduced microglial activation, reduced susceptibility to hippocampal long-term depression, increased protein levels for the GluR1 type glutamate receptor, and lower L-type voltage sensitive Ca2+ channel (VSCC) activity in hippocampal CA1 neurons. The results suggest that diverse functional changes associated with brain aging may arise, in part, from selective alterations in TNF signaling

The Community Anchor Institutions of Champaign-Urbana, Illinois Technology Use by Non-Profit and Public Organizations in the Broadband Moment

published or submitted for publicatio

JCOERE’s perspective on European integration and the scope of mutual trust and cooperation between courts: testing fairness

In this blog post, Professor Irene Lynch Fannon and Dr Jennifer LL Gant discuss key elements of the JCOERE project research relating to European Integration and judicial cooperation. It provides an insight into some of the research questions which have been considered in the second project Report, namely that factors such as mutual trust and European integration are intrinsically linked to achieving effective cooperation amongst courts. The blog post considers a particular area of conflict which has arisen in preventive restructuring cases across the EU: the assessment of restructuring plan fairness. It considers the varied approaches to testing fairness which exist in common law and civil law jurisdictions, and discusses whether testing fairness will continue to give rise to conflict following Member State implemention of the Preventive Restructuring Directive