Violation of Bell's inequality for phase singular beams

We have considered optical beams with phase singularity and experimentally verified that these beams, although being classical, have properties of two mode entanglement in quantum states. We have observed the violation of Bell's inequality for continuous variables using the Wigner distribution function (WDF) proposed by Chowdhury et al. [Phys. Rev. A \textbf{88}, 013830 (2013)]. Our experiment establishes a new form of Bell's inequality in terms of the WDF which can be used for classical as well as quantum systems.Comment: 7 pages, 9 figures and 1 tabl

Paracoccidioides Brasiliensis Infection Promotes Thymic Disarrangement And Premature Egress Of Mature Lymphocytes Expressing Prohibitive Tcrs

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Paracoccidioidomycosis, a chronic granulomatous fungal disease caused by Paracoccidioides brasiliensis yeast cells affects mainly rural workers, albeit recently cases in immunosuppressed individuals has been reported. Protective immune response against P. brasiliensis is dependent on the activity of helper T cells especially IFN-gamma-producing Th1 cells. It has been proposed that Paracoccidioides brasiliensis is able to modulate the immune response towards a permissive state and that the thymus plays a major role in it. Methods: In this paper, we show that acute infection of BALB/c mice with P. brasiliensis virulent isolate (Pb18) might cause alterations in the thymic environment as well as the prohibitive TCR-expressing T cells in the spleens. Results: After seven days of infection, we found yeast cells on the thymic stroma, the thymic epithelial cells (TEC) were altered regarding their spatial-orientation and inflammatory mediators gene expression was increased. Likewise, thymocytes (differentiating T cells) presented higher migratory ability in ex vivo experiments. Notwithstanding, P. brasiliensis-infected mice showed an increased frequency of prohibitive TCR-expressing T cells in the spleens, suggesting that the selection processes that occur in the thymus may be compromised during the acute infection. Conclusion: In this paper, for the first time, we show that acute infection with Paracoccidioides brasiliensis yeast cells promotes thymic alterations leading to a defective repertoire of peripheral T cells. The data presented here may represent new mechanisms by which P. brasiliensis subverts the immune response towards the chronic infection observed in humans.16Sao Paulo Research Foundation (FAPESP) [2012/22131-7, 2013/01401-9, 2013/08194-9, 2014/02631-0]Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP

Modeling Evacuation Risk Using a Stochastic Process Formulation of Mesoscopic Dynamic Network Loading

One of the actions usually conducted to limit exposure to a hazardous event is the evacuation of the area that is subject to the effects of the event itself. This involves modifications both to demand (a large number of users all want to move together) and to supply (the transport network may experience changes in capacity, unusable roads, etc.). In order to forecast the traffic evolution in a network during an evacuation, a natural choice is to adopt an approach based on Dynamic Traffic Assignment (DTA) models. However, such models typically give a deterministic prediction of future conditions, whereas evacuations are subject to considerable uncertainty. The aim of the present paper is to describe an evacuation approach for decision support during emergencies that directly predicts the time-evolution of the probability of evacuating users from an area, formulated within a discrete-time stochastic process modelling framework. The approach is applied to a small artificial case as well as a real-life network, where we estimate users' probabilities to reach a desired safe destination and analyze time dependent risk factors in an evacuation scenario

What to Expect from COVID-19 and from COVID-19 Vaccine for Expecting or Lactating Women

Recent studies identified pregnancy as a high-risk condition for the development of maternal-fetal complications in the case of the SARS-CoV-2 infection. Therefore, the scientific community is now considering pregnant women a "fragile" category that should be vaccinated with high priority. The number of pregnant women undergoing hospitalization since summer 2021, including Intensive Care Unit admission, is growing, as well as the risk of preterm birth. Evidence from both animals and humans suggest that, similarly to other vaccines routinely administered in pregnancy, COVID-19 vaccines are not crossing the placenta, do not increase the risk of miscarriage, preterm birth, stillbirth, the birth of small gestational age neonates, as well as the risk of congenital abnormalities. To date, the World Health Organization and scientific literature are promoting and encouraging the vaccination of all pregnant and lactating women. The aim of our narrative review is to present the available literature regarding this issue with the aim to provide appropriate answers to the most frequent requests, doubts, and fears that have led many expecting and lactating women not to become vaccinated during this pandemic period