A new spin-anisotropic harmonic honeycomb iridate

The physics of Mott insulators underlies diverse phenomena ranging from high temperature superconductivity to exotic magnetism. Although both the electron spin and the structure of the local orbitals play a key role in this physics, in most systems these are connected only indirectly --- via the Pauli exclusion principle and the Coulomb interaction. Iridium-based oxides (iridates) open a further dimension to this problem by introducing strong spin-orbit interactions, such that the Mott physics has a strong orbital character. In the layered honeycomb iridates this is thought to generate highly spin-anisotropic interactions, coupling the spin orientation to a given spatial direction of exchange and leading to strongly frustrated magnetism. The potential for new physics emerging from such interactions has driven much scientific excitement, most recently in the search for a new quantum spin liquid, first discussed by Kitaev \cite{kitaev_anyons_2006}. Here we report a new iridate structure that has the same local connectivity as the layered honeycomb, but in a three-dimensional framework. The temperature dependence of the magnetic susceptibility exhibits a striking reordering of the magnetic anisotropy, giving evidence for highly spin-anisotropic exchange interactions. Furthermore, the basic structural units of this material suggest the possibility of a new family of structures, the `harmonic honeycomb' iridates. This compound thus provides a unique and exciting glimpse into the physics of a new class of strongly spin-orbit coupled Mott insulators.Comment: 12 pages including bibliography, 5 figure

Programa de Excelência em Gestão: o caso da Frísia Cooperativa Agroindustrial

This case study addresses the application of the Management Excellence Program at Frísia Cooperativa Agroindustrial, using the Cooperative Management Development Program tool (PDGC), which is based on the Management Excellence Model (MEG) of the National Quality Foundation (FNQ). We evaluate the applicability of the tool which makes a diagnosis of the governance and management structure of the cooperative and aims at continuous improvement in each PDCL (Plan, Do, Check, and Learn) cycle. In order to get more information, we carried out a semi-structured interview with the governance agents of Frísia. The data (made available by SESCOOP-PR, with the consent of the cooperative) refers to the PDGC cycles of 2017 and 2018. Results show that the SESCOOP Cooperative Governance Index (ISGC) increased from 63.3% in 2017 to 87.0% in 2018, as well as the SESCOOP Management Index (ISG), which increased from 50.3% in 2017 to 69.4% in 2018.Este estudo de caso aborda a aplicação do Programa de Excelência em Gestão na Frísia Cooperativa Agroindustrial, utilizando a ferramenta do Programa de Desenvolvimento da Gestão das Cooperativas (PDGC), que faz um diagnóstico da governança e da gestão da cooperativa, visando à melhoria contínua a cada ciclo de planejamento, execução, controle e aprendizado. Foram disponibilizados dados pelo SESCOOP-PR, com anuência da cooperativa, referente aos ciclos do PDGC dos anos de 2017 e 2018. Verificou-se que o Índice SESCOOP de Governança Cooperativista (ISGC) passou de 63,3% em 2017 para 87,0% em 2018. E o Índice SESCOOP de Gestão (ISG) passou de 50,3% em 2017 para 69,4% em 2018. Para complementar as informações, foi realizada uma entrevista semiestruturada com os agentes de governança da Frísia. A análise dos resultados indica que uma estrutura de governança capaz de integrar as diferentes partes interessadas tem efeitos práticos na efetividade da gestão da cooperativa.

Blood Meal-Derived Heme Decreases ROS Levels in the Midgut of Aedes aegypti and Allows Proliferation of Intestinal Microbiota

The presence of bacteria in the midgut of mosquitoes antagonizes infectious agents, such as Dengue and Plasmodium, acting as a negative factor in the vectorial competence of the mosquito. Therefore, knowledge of the molecular mechanisms involved in the control of midgut microbiota could help in the development of new tools to reduce transmission. We hypothesized that toxic reactive oxygen species (ROS) generated by epithelial cells control bacterial growth in the midgut of Aedes aegypti, the vector of Yellow fever and Dengue viruses. We show that ROS are continuously present in the midgut of sugar-fed (SF) mosquitoes and a blood-meal immediately decreased ROS through a mechanism involving heme-mediated activation of PKC. This event occurred in parallel with an expansion of gut bacteria. Treatment of sugar-fed mosquitoes with increased concentrations of heme led to a dose dependent decrease in ROS levels and a consequent increase in midgut endogenous bacteria. In addition, gene silencing of dual oxidase (Duox) reduced ROS levels and also increased gut flora. Using a model of bacterial oral infection in the gut, we show that the absence of ROS resulted in decreased mosquito resistance to infection, increased midgut epithelial damage, transcriptional modulation of immune-related genes and mortality. As heme is a pro-oxidant molecule released in large amounts upon hemoglobin degradation, oxidative killing of bacteria in the gut would represent a burden to the insect, thereby creating an extra oxidative challenge to the mosquito. We propose that a controlled decrease in ROS levels in the midgut of Aedes aegypti is an adaptation to compensate for the ingestion of heme

Armas i triunfos : hechos heroicos de los hijos de Galicia ... resumen de los seruicios que este reino a echo à ... Felipe IV...

ColofónSign.: a\p4\s, b\p8\s, A-Z\p8\s, 2A-2Z\p8\s, 3A\p4\sPort. con grab. cal

El cisne occidental canta las palmas y triunfos eclesiasticos del reino de Galicia ganados por sus hijos insignes ... : obra postuma

Fecha de la fe de erratas, 1678Sign.: [ ]\p2\s, A-Z\p8\s, 2A-2B\p8\s, 2C\p10\s, A-B\p6\s, C\p8\sErrores de pag. a partir de p. 95Texto a dos colPort. con orla tipLas dos h. de grab. calc., la segunda un esc. heraldico: "Gregorio Fosman faciebat Matriti, 1677

Descripcion, armas, origen y descendencia de la muy noble y antigua casa de Calderon de la Barca, y sus succesiones continuadas

Fecha de la tasa y de la fe de erratas, 1753Sign.: [calderón]\p2\s, 2[calderón]\p4\s, 3[calderón]\p2\s, A-2O\p4\s, 2P\p5\sDe las h. de grab., una xil., escudo de la Casa Calderon de la Barca y la otra calc.: ¨Bailly excud:¨, retr. de S. Francisco de Así

Nobiliario armas y triunfos de Galicia hechos heroicos de sus hijos y elogios de su nobleza y de la mayor de España y Europa

Sign.: [calderón]\p6\s, A-Z\p6\s, 2A-2R\p6\s, 2S\p2\s, A-O\p6\sEsc. heráldico en p. 393Texto a dos colPort con orla tipPort con grab. xilLas hojas de grab. son calc., una firmada: "Gregorio Fosman faciebat Matriti 1677