Distribution of the surface energy budget: Preliminary analysis on the incoming solar radiation. the case study of the Forni Glacier (Italy)

This study represents a contribution to distribution of the surface energy budget of the Forni Glacier (Ortles-Cevedale Group, Upper Valtellina, Italy). The analyses are based on data acquired at S. Caterina Valfurva (a village in the glacier valley at 1768 m ellipsoidal elevation WGS84) by an Automatic Weather Station (AWS) installed and managed by the Lombardy Agency for the Environment ("ARPA Lombardia"). We focus on the two most important meteorological parameters affecting surface energy budget: air temperature (T) and incoming shortwave radiation (SWin). Data collected from the ARPA AWS are used to evaluate these parameters at the glacier surface during the meteorological summer 2009 (from 1st June to 31st August 2009) and then the computations are validated through comparison with data recorded by an AWS installed at the surface of Forni Glacier tongue ("AWS1 Forni", 2669 m ellipsoidal elevation WGS84). The analysis of the distributed air temperature data enabled identification of the lowest value (-11.9 degrees C), found at the Mount S. Matteo peak (3669 m) on 22nd June at 8: 00 pm, and the highest value (+16.1 degrees C), recorded at the glacier terminus (2497 m) on 23 rd July at 2: 00 pm. The seasonal temperature amplitude (Tmax-Tmin) was 28 degrees C. The hottest week was 20th-26th July 2009 and the coldest was 1st-7th June 2009. Regarding daily SWin distribution, the maximum value (406.9 Wm(-2)) was recorded on 13th June and the minimum (28.5 Wm(-2)) on 6th June. From the analysis of hourly SWin values we could distinguish between days with clear sky conditions and days with intense cloud cover. Weekly mean SWin data showed the greatest value (327.1 Wm(-2)) from 20th-26th July 2009 and the lowest (207.8 Wm(-2)) from 22nd-28th June 2009. Furthermore, in analysing SWin it is critical to take into account the problem of shading. Using the Hillshade tool of ArcGIS, which takes into account only the slope and the aspect of each grid cell neglecting the surrounding topography effect, we compiled 66 shadow maps. Finally this study represents a first approach in modelling the distributed incoming solar radiation. In fact the considered driving factors are the elevation, the slope and the aspect of each grid cell. The next step will consist in taking into account the surrounding topography and the actual atmosphere conditions as well

CONGENITAL MYOPATHIES

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CONGENITAL MYOPATHIES

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Unexpected impairment of INa underpins reentrant arrhythmias in a knock-in swine model of Timothy syndrome

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Systemic Inhibition of NF-κB Activation Protects from Silicosis

Background: Silicosis is a complex lung disease for which no successful treatment is available and therefore lung transplantation is a potential alternative. Tumor necrosis factor alpha (TNFα) plays a central role in the pathogenesis of silicosis. TNFα signaling is mediated by the transcription factor, Nuclear Factor (NF)-κB, which regulates genes controlling several physiological processes including the innate immune responses, cell death, and inflammation. Therefore, inhibition of NF-κB activation represents a potential therapeutic strategy for silicosis. Methods/Findings: In the present work we evaluated the lung transplant database (May 1986-July 2007) at the University of Pittsburgh to study the efficacy of lung transplantation in patients with silicosis (n = 11). We contrasted the overall survival and rate of graft rejection in these patients to that of patients with idiopathic pulmonary fibrosis (IPF, n = 79) that was selected as a control group because survival benefit of lung transplantation has been identified for these patients. At the time of lung transplantation, we found the lungs of silica-exposed subjects to contain multiple foci of inflammatory cells and silicotic nodules with proximal TNFα expressing macrophage and NF-κB activation in epithelial cells. Patients with silicosis had poor survival (median survival 2.4 yr; confidence interval (CI): 0.16-7.88 yr) compared to IPF patients (5.3 yr; CI: 2.8-15 yr; p = 0.07), and experienced early rejection of their lung grafts (0.9 yr; CI: 0.22-0.9 yr) following lung transplantation (2.4 yr; CI:1.5-3.6 yr; p<0.05). Using a mouse experimental model in which the endotracheal instillation of silica reproduces the silica-induced lung injury observed in humans we found that systemic inhibition of NF-κB activation with a pharmacologic inhibitor (BAY 11-7085) of IκBα phosphorylation decreased silica-induced inflammation and collagen deposition. In contrast, transgenic mice expressing a dominant negative IκBα mutant protein under the control of epithelial cell specific promoters demonstrate enhanced apoptosis and collagen deposition in their lungs in response to silica. Conclusions: Although limited by its size, our data support that patients with silicosis appear to have poor outcome following lung transplantation. Experimental data indicate that while the systemic inhibition of NF-κB protects from silica-induced lung injury, epithelial cell specific NF-κB inhibition appears to aggravate the outcome of experimental silicosis. © 2009 Di Giuseppe et al