Photosensitivity Color-Center Model for Ge-Doped Silica Preforms

A new photosensitivity physical model for Ge-doped silica preforms based on color-center photoreactions is presented. Simulation results are in close agreement with experimental results obtained by several condensed matter physics research groups working in this field, suggesting that the photoreactions of this model may, indeed, describe the physical processes involved in Ge-doped silica preform photosensitivity. The proposed photosensitivity model is defined by two differential equations that describe the temporal evolution of a set of color-center concentrations. The first is a modification of a very fast reversible reaction previously proposed by Fujimaki et al., where the reaction precursor has a different chemical structure (it is a neutral oxygen divacancy NODV unrelated to the previously proposed germanium lone pair center GLPC). The chemical structure of this precursor defect explains the generation of nonintrinsic neutral oxygen monovacancy ðNOMVÞ color centers. These centers are transformed into GeE0 defects by means of a second nonlinear reaction. This justifies the slow increase in the absorption peak experimentally measured at 6.3 eV, which had no satisfactory explanation.Ministerio de Ciencia y Tecnología TIC2001-2969-C03-0

Conducta de los Enfermeros Frente a las Alarmas Clínicas en Unidades de Cuidados Intensivos: una Revisión Integradora

O presente estudo tem como propósito refletir sobre a prática de enfermagem no que concerne à temática da monitorização hemodinâmica. Pretendemos identificar a evidência empírica produzida sobre o comportamento dos enfermeiros perante os alarmes clínicos e, consequentemente, incentivar a adoção de estratégias que promovam um ambiente de cuidados intensivos menos ruidoso. Perspetivou-se um estudo de revisão sistemática da literatura. Selecionámos um conjunto de dezoito bases de dados eletrónicas, tendo recorrido a três idiomas. A colheita de informação decorreu entre dezembro de 2011 e janeiro de 2012 e, através de uma estratégia de cruzamento dos descritores selecionados, foram incluídos 5 artigos. Face a todo o corpo de discussão salientamos três categorias essenciais: opinião dos profissionais de saúde acerca dos alarmes clínicos; comportamento dos profissionais; estratégias promotoras de um ambiente menos ruidoso. Constatamos que os profissionais de saúde têm presente a bipolaridade dos alarmes clínicos e identificam limitações na sua gestão. Verificamos ainda que o comportamento dos profissionais nos estudos analisados não é linear, variando entre alterar os parâmetros no início de cada turno até ignorar uma grande maioria deles. Cientes desta realidade, os profissionais sugerem diversas estratégias passíveis de implementar, com vista a alarmes e comportamentos mais eficazes

Recomendações técnicas para a reprodução do tambaqui.

Das espécies nativas brasileiras, o tambaqui (Colossoma macropomum) é a mais produzida em cativeiro. Quase a totalidade da produção desse animal puro ocorre nos estados da região Norte do Brasil, com destaque para Rondônia. No Mato Grosso, existe grande produção do híbrido tambacu (tambaqui x pacu-caranha, Piaractus mesopotamicus). Isso se deve à popularidade do pacu-caranha na bacia do rio Paraguai e do repasse de tecnologia, no início dos anos 1980, do Centro Nacional de Pesquisa e Conservação de Peixes Continentais (Cepta), que recomendava a produção do híbrido com o objetivo de explorar o potencial de crescimento do tambaqui associado à resistência do pacu a temperaturas amenas. Atualmente, outro híbrido bastante produzido é o tambatinga, cruzamento de duas espécies amazônicas (tambaqui x pirapitinga, Piaractus brachypomus) com características produtivas parecidas com as do tambacu, mas com destaque para a cor prateada e o opérculo avermelhado, os quais chamam a atenção do consumidor. Desse modo, este manual vai tratar exclusivamente da tecnologia aplicada à reprodução do tambaqui, desenvolvida pela UFRGS, UEM e UFMT com apoio da Embrapa, por meio do Programa de Melhoramento Genético de Organismos Aquáticos, no âmbito do projeto AQUABRASIL.bitstream/item/83462/1/Doc-212-RecomendacoesTecnicasReproducaoTambaqui.pd

Synergistic Degradation Mechanism in Single Crystal Ni-Rich NMC//Graphite Cells

Acknowledgments We acknowledge Diamond Light Source for time on beamline I09 under Proposals SI30201-1 and SI30201-2. This work is supported by the Faraday Institution under Grants FIRG044, FIRG024, and FIRG060.Peer reviewedPublisher PD

Retinal cells derived from patients with DRAM2-dependent CORD21 dystrophy exhibit key lysosomal enzyme deficiency and lysosomal content accumulation

\ua9 2024 The Author(s)Biallelic mutations in DRAM2 lead to an autosomal recessive cone-rod dystrophy known as CORD21, which typically presents between the third and sixth decades of life. Although DRAM2 localizes to the lysosomes of photoreceptor and retinal pigment epithelium (RPE) cells, its specific role in retinal degeneration has not been fully elucidated. In this study, we generated and characterized retinal organoids (ROs) and RPE cells from induced pluripotent stem cells (iPSCs) derived from two CORD21 patients. Our investigation revealed that CORD21-ROs and RPE cells exhibit abnormalities in lipid metabolism, defects in autophagic flux, accumulation of aberrant lysosomal content, and reduced lysosomal enzyme activity. We identified potential interactions of DRAM2 with vesicular trafficking proteins, suggesting its involvement in this cellular process. These findings collectively suggest that DRAM2 plays a crucial role in maintaining the integrity of photoreceptors and RPE cells by regulating lysosomal function, autophagy, and potentially vesicular trafficking

Beliefs and preferences regarding biological treatments for severe asthma

Background: Severe asthma is a serious condition with a significant burden on patients' morbidity, mortality, and quality of life. Some biological therapies targeting the IgE and interleukin-5 (IL5) mediated pathways are now available. Due to the lack of direct comparison studies, the choice of which medication to use varies. We aimed to explore the beliefs and practices in the use of biological therapies in severe asthma, hypothesizing that differences will occur depending on the prescribers’ specialty and experience. Methods: We conducted an online survey composed of 35 questions in English. The survey was circulated via the INterasma Scientific Network (INESNET) platform as well as through social media. Responses from allergists and pulmonologists, both those with experience of prescribing omalizumab with (OMA/IL5) and without (OMA) experience with anti-IL5 drugs, were compared. Results: Two hundred eighty-five (285) valid questionnaires from 37 countries were analyzed. Seventy-on percent (71%) of respondents prescribed biologics instead of oral glucocorticoids and believed that their side effects are inferior to those of Prednisone 5 mg daily. Agreement with ATS/ERS guidelines for identifying severe asthma patients was less than 50%. Specifically, significant differences were found comparing responses between allergists and pulmonologists (Chi-square test, p < 0.05) and between OMA/IL5 and OMA groups (p < 0.05). Conclusions: Uncertainties and inconsistencies regarding the use of biological medications have been shown. The accuracy of prescribers to correctly identify asthma severity, according to guidelines criteria, is quite poor. Although a substantial majority of prescribers believe that biological drugs are safer than low dose long-term treatment with oral steroids, and that they must be used instead of oral steroids, every effort should be made to further increase awareness. Efficacy as disease modifiers, biomarkers for selecting responsive patients, timing for outcomes evaluation, and checks need to be addressed by further research. Practices and beliefs regarding the use of asthma biologics differ between the prescriber's specialty and experience; however, the latter seems more significant in determining beliefs and behavior. Tailored educational measures are needed to ensure research results are better integrated in daily practice

Measurement of the production of a W boson in association with a charmed hadron in pp collisions at √s=13 TeV with the ATLAS detector

Álvarez Piqueras, D.; Amos, K.R. ; Aparisi, Pozo, J.A.; Bailey, A.J.; Barranco, Laura; Bouchhar, Naseem; Cabrera, Susana; Cantero, Josu; Cardillo, Fabio Castillo, F.L.; Castillo Mª Victoria; Chitishvili, Mariam Cerda Alberich, L.; Costa, María José; Didenko, Mariia , Escobar, Carlos; Estrada, Oscar; Ferrer, Antonio; Fiorini, L.; Fullana, Esteban; Fuster, Juan; García García, Carmen; García Navarro, José Enrique; Gomez Delegido, A.J.; González de la Hoz, Santiago; Gonzalvo Rodríguez, Galo Rafael; Guerrero Rojas, J.G.R.; Higón, Emilio; Jimenez Pena, Javier; Lacasta Llácer, Carlos; Lozano Bahilo, José J.; Madaffari, Daniele; Mamuzic, Judita; Martí García, Salvador; Martinez Agullo, Pablo;; Melini, Davide; Miñano Moya, M.; Mitsou, Vasiliki A.; Miralles López, Marcos; Monsonis Romero, Luis; Moreno Llácer, María; Muñoz Perez, David; Navarro Gonzalez, Josep; Poveda, Joaquín; Prades Ibañez, Alberto; Rodriguez Bosca, S.; Rodriguez Rodriguez, D.; Rubio Jiménez, Adrián ; Ruiz Martínez, Arantxa; Sabatini, Paolo , Salt, José; Sanchez Sebastian, Victoria Santra, A.; Sánchez Martínez, Javier; Sayago Galvan, Ivan; Senthilkumar, Varsha ; Soldevila, Urmila; Torró Pastor, Emma; Valero, Alberto; Valls Ferrer, Juan Antonio; Valiente Moreno, Enrique ; Villaplana Pérez, Miguel , Varriale, Lorenzo; Vos, Marcel; ATLAS CollaborationThe production of a W boson in association with a single charm quark is studied using 140 fb - 1 of s = 13 TeV proton-proton collision data collected with the ATLAS detector at the Large Hadron Collider. The charm quark is tagged by the presence of a charmed hadron reconstructed with a secondary-vertex fit. The W boson is reconstructed from the decay to either an electron or a muon and the missing transverse momentum present in the event. The charmed mesons reconstructed are D + → K - π + π + and D * + → D 0 π + → ( K - π + ) π + and the charge conjugate decays in the fiducial regions where p T ( e , μ ) > 30 GeV , | η ( e , μ ) | 8 GeV , and | η ( D ( * ) ) | < 2.2 . The integrated and normalized differential cross sections as a function of the pseudorapidity of the lepton from the W boson decay, and of the transverse momentum of the charmed hadron, are extracted from the data using a profile likelihood fit. The measured total fiducial cross sections are σ fid OS - SS ( W - + D + ) = 50.2 ± 0.2 ( stat ) - 2.3 + 2.4 ( syst ) pb , σ fid OS - SS ( W + + D - ) = 48.5 ± 0.2 ( stat ) - 2.2 + 2.3 ( syst ) pb , σ fid OS - SS ( W - + D * + ) = 51.1 ± 0.4 ( stat ) - 1.8 + 1.9 ( syst ) pb , and σ fid OS - SS ( W + + D * - ) = 50.0 ± 0.4 ( stat ) - 1.8 + 1.9 ( syst ) pb . Results are compared with the predictions of next-to-leading-order quantum chromodynamics calculations performed using state-of-the-art parton distribution functions. Additionally, the ratio of charm to anticharm production cross sections is studied to probe the s - s ¯ quark asymmetry. The ratio is found to be R c ± = 0.971 ± 0.006 ( stat ) ± 0.011 ( syst ) . The ratio and cross-section measurements are consistent with the predictions obtained with parton distribution function sets that have a symmetric s - s ¯ sea, indicating that any s - s ¯ asymmetry in the Bjorken- x region relevant for this measurement is small