Oesophageal cancer in women: tobacco, alcohol, nutritional and hormonal factors

We analysed 3 case–control studies from Italy and Switzerland including 114 women with squamous cell oesophageal cancer and 425 controls. The multivariate odds ratio was 4.5 for heavy smoking and 5.4 for heavy alcohol drinking. Fruit intake, vegetable intake, oral contraceptive and HRT use were inversely related to oesophageal cancer. © 2001 Cancer Research Campaign http://www.bjcancer.co

Leanness and squamous cell oesophageal cancer

Background: Squamous cell oesophageal cancer is one of the few neoplasms inversely related to body mass index (BMI). However, it is not clear whether this is due to cancer-related weight loss or to other correlates of leanness. Patients and methods: 395 incident, histologically confirmed cases of squamous cell oesophageal cancer and 1,066 controls, admitted for acute, non-neoplastic diseases, in Italy and Switzerland. Odds ratios (ORs) were derived from multiple logistic regression, including terms for education, tobacco, alcohol, non-alcohol energy, fruit and vegetable intake Results: The ORs for the lowest vs. the highest quartile of BMI in the year before diagnosis were 2.0 in men, 1.6 in women, and 1.9 (95% confidence interval: 1.3-2.9) in both sexes combined. The association with leanness was stronger in heavy smokers, but was not accounted for by smoking and drinking, nor by differences in diet. Weight change in the decade prior to diagnosis showed no linear association with risk. However, cases were not leaner than controls at age 30 (OR = 0.6 for the lowest BMI quartile) and 50 (OR = 1.1). Conclusions: Leanness appears to be an indicator of squamous cell oesophageal carcinogenesis. However, low BMI in the distant past was unrelated to oesophageal cancer ris

Does coffee protect against hepatocellular carcinoma?

We analysed the relation between coffee consumption and hepatocellular carcinoma in two case-control studies conducted between 1984 and 1998 in Italy and Greece, including 834 cases and 1912 controls. Compared to non coffee drinkers, the multivariate odds ratio was 0.7 for drinkers of three or more cups per day

Surface Display of Complex Enzymes by in Situ SpyCatcher-SpyTag Interaction

The display of complex proteins on the surface of cells is of great importance for protein engineering and other fields of biotechnology. Herein, we describe a modular approach, in which the membrane anchor protein Lpp-OmpA and a protein of interest (passenger) are expressed independently as genetically fused SpyCatcher and SpyTag units and assembled in situ by post-translational coupling. Using fluorescent proteins, we first demonstrate that this strategy allows the construct to be installed on the surface of E. coli cells. The scope of our approach was then demonstrated by using three different functional enzymes, the stereoselective ketoreductase Gre2p, the homotetrameric glucose 1-dehydrogenase GDH, and the bulky heme- and diflavin-containing cytochrome P450 BM3 (BM3). In all cases, the SpyCatcher-SpyTag method enabled the generation of functional whole-cell biocatalysts, even for the bulky BM3, which could not be displayed by conventional fusion with Lpp-OmpA. Furthermore, by using a GDH variant carrying an internal SpyTag, the system could be used to display an enzyme with unmodified N- and C-termini

Let’s Take A Walk: Exploring the Impact of an Inclusive Walking Program on the Physical and Mental Health of Adults with Intellectual Disability

Background: People with intellectual disabilities experience health disparities and poorer health outcomes than people without disabilities. Increased physical activity has been found to reduce the impact of chronic health conditions among people with intellectual disabilities. Method: The current study explored the impact of an inclusive walking program on the physical and mental health of adults with intellectual disabilities. Let’s Take A Walk paired adults with intellectual disabilities, hereafter referred to as Community Walkers (n = 27), with college students to walk around a college campus twice a week for 45 minutes across 10 weeks. Data on mental health outcomes, specifically depression and anxiety, were collected from 24 Community Walkers across four-time points (pre-, mid-, post-, and 3-months following intervention), and data on physical health outcomes were collected across two-time points (pre- and post-intervention). Results: Community Walkers reported significant decreases in both depression and anxiety from pre to post-implementation. Particularly promising was clinically significant decreases in anxiety symptoms over the 10-week program. No differences were noted on Community Walkers’ measures of physical health. Conclusion: Inclusive walking programs are a valuable and promising mechanism for building social connections and inclusion and improving mental health for adults with intellectual disabilities

Quantifying and Interpreting Connection Strength in Macroand Microscopic Systems: Lessons from Bell’s Approach

Bell inequalities were created with the goal of improving the understanding of foundational questions in quantum mechanics. To this end, they are typically applied to measurement results generated from entangled systems of particles. They can, however, also be used as a statistical tool for macroscopic systems, where they can describe the connection strength between two components of a system under a causal model. We show that, in principle, data from macroscopic observations analyzed with Bell’ s approach can invalidate certain causal models. To illustrate this use, we describe a macroscopic game setting, without a quantum mechanical measurement process, and analyze it using the framework of Bell experiments. In the macroscopic game, violations of the inequalities can be created by cheating with classically defined strategies. In the physical context, the meaning of violations is less clear and is still vigorously debated. We discuss two measures for optimal strategies to generate a given statistic that violates the inequalities. We show their mathematical equivalence and how they can be computed from CHSH-quantities alone, if non-signaling applies. As a macroscopic example from the financial world, we show how the unfair use of insider knowledge could be picked up using Bell statistics. Finally, in the discussion of realist interpretations of quantum mechanical Bell experiments, cheating strategies are often expressed through the ideas of free choice and locality. In this regard, violations of free choice and locality can be interpreted as two sides of the same coin, which underscores the view that the meaning these terms are given in Bell’s approach should not be confused with their everyday use. In general, we conclude that Bell’s approach also carries lessons for understanding macroscopic systems of which the connectedness conforms to different causal structures

COVID-19 lockdown: The relationship between trait impulsivity and addictive behaviors in a large representative sample of Italian adults

open9noBackground: The importance of trait impulsivity in development, continuation and escalation of addictive behaviors has long been recognized. Methods: A cross-sectional population-based survey was conducted during the COVID-19 lockdown on 6003 Italian adults aged 18–74 years, representative of the Italian general population, to investigate the relationship between impulsivity (Barratt Impulsiveness Scale – BIS) and selected addictive behaviors (gambling habits, smoking status, cannabis use, average alcohol daily use). Results: A statistically significant relationship was found between motor impulsivity and starting/increasing drinking and increasing gambling (high vs. low motor impulsivity: multivariate odds ratio, OR=3.12; 95% confidence interval, CI: 1.45–6.74; p for trend=0.004 for start and OR=1.53; 95% CI: 1.26–1.86; p for trend<0.001 for increase drinking, respectively; OR=2.09; 95% CI: 1.41–3.12; p for trend<0.001 for increasing gambling). Limitations: Potential information and recall bias. The necessity to limit the length of the questionnaire not to reduce the quality of the answers of study participants. Conclusions: The multifaceted nature of impulsivity, potentially either cause or effect, hampers the understanding of its proper role in addictive behaviors. If confirmed by future longitudinal studies, our findings might support the planning, implementation and monitoring of evidence-based preventive interventions, to reduce addictive behaviors during public health emergencies.openAmerio A.; Stival C.; Lugo A.; Fanucchi T.; Gorini G.; Pacifici R.; Odone A.; Serafini G.; Gallus S.Amerio, A.; Stival, C.; Lugo, A.; Fanucchi, T.; Gorini, G.; Pacifici, R.; Odone, A.; Serafini, G.; Gallus, S