Ways for Recycling of Quartz Waste in the Production of Silicate Materials

The technological properties of quartz waste associated with the clay deposit are investigated by way of emission spectral analysis, petrography and X-ray phase analysis. This study considers the possibility of quartz waste utilization in the production of dry building mixtures as a filler, magnesia-quartz proppants as a raw material component, cement as a siliceous component, fine ceramics as a partially fluxing and exhausting component, silicate brick as the main raw material. In the production of glass and glassware it is possible to make use of the quartz waste as a glass-forming component including silicate blocks after refining for the Al2O3 and Fe2O3 content. Quartz waste can be recommended as molding sand after refining for the contents of Fe2O3, Na2O, K2O, MgO, CaO. Improvement of the properties of the quartz waste can be achieved by ways of elutriation to remove the clay component as well as magnetic separation to remove magnetic compounds of iron. Keywords: quartz waste, proppants, glass, cement, silicate brick, building mixtures, fine ceramics, molding sand, recyclin

Storm Surges and Extreme Wind Waves in the Caspian Sea in the Present and Future Climate

The Caspian Sea is of particular interest. Against the background of long-term sea level changes, low-lying coastal areas in the northern part are subject to constant flooding as a result of storm surges. The elongation of the sea in the meridional direction allows the development of strong waves in the middle and southern parts. A comprehensive understanding of the characteristics of storm surges and storm waves is especially important in the context of ongoing climate change. This study is devoted to the analysis of storm surges for the time period from 1979 up to 2017 and wind waves from 1979 to 2020 in the Caspian Sea region. The circulation model ADCIRC and the wave model WAVEWATCH III with wind and pressure forcing from the NCEP/CFSR reanalysis were used. The modeling is performed on different unstructured grids with spacings of 500–900 m in the coastal zone. Mean and extreme values of surges, wave parameters and storm activity are provided in the research. The maximum significant wave height for the whole period was 8.2 m. The average long-term SWH did not exceed 1.1 m. No significant trends in the storm activity were found. The maximum surge height was 2.7 m. The analysis of the interannual variability of the surges' occurrence showed that 7–10 surges with a height of more than 1 meter were detected every year. The total duration of these surges was 20–30 days per year. Assessment of the risks of coastal flooding was carried out by calculating the extreme values of the sea for different return periods: 5, 10, 25, 50, and 100 years. The extreme sea level values in the northern part of the Caspian Sea for the 100-year return period are close to 3 m, and the areas with big surges are located along the eastern and western coasts. A forecast is made for the recurrence of storm wind waves in the 21st century based on climatic scenarios in CMIP5. A statistically significant increase in the recurrence of storm waves is to be expected in the near future, but that increase is not severe. Doi: 10.28991/CEJ-2022-08-11-01 Full Text: PD

The role of some indicators of financial security in Ukraine in the context of transnationalization and national interests

The article analyzes some indicators of Ukraine’s financial security in the context of transnationalization and national interests. On the basis of the obtained results, the role of financial security in the context of transnationalization and national interests has been determined, directions for strengthening the financial security of the country have been proposed.The main objective of the study is to determine the role of Ukraine’s financial security in the context of transnationalization and national interests, based on the study and evaluation of some financial security indicators. The methodology of the research is based on the early prevention of threats to financial security of Ukraine in the context of transnationalization and national interests, based on both macroeconomic and financial data from the entire financial system. The regression models were used, because they work dynamically and change as information changes. Diagrams can be used by financial analysts to understand the investment attractiveness of the country at the current time with the current level of financial security. Standard models are designed to predict the financial stress and threats to financial security. Financial security models must be built with the support of macroeconomic knowledge, assessment of other risks and expert interpretations, used to get the highest value in the research.The procedure of simulation of financial security indicators of the country has been given. The use of correlation and regression analysis for forecasting the financial security indicators in Ukraine has been substantiated. The links between the indicator variables have been analyzed. The general view of model relations between financial security indicators in Ukraine has been determined, their statistical analysis has been carried out and the necessity of forecasting the financial security indicators of Ukraine has been substantiated

The Role of 5-ALA in Low-Grade Gliomas and the Influence of Antiepileptic Drugs on Intraoperative Fluorescence

Objectives: Intraoperative tumor visualization with 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX (PpIX) fluorescence is widely applied for improved resection of high-grade gliomas. However, visible fluorescence is present only in a minority of low-grade gliomas (LGGs) according to current literature. Nowadays, antiepileptic drugs (AEDs) are frequently administered to LGG patients prior to surgery. A recent in-vitro study demonstrated that AEDs result in significant reduction of PpIX synthesis in glioma cells. The aim of this study was thus to investigate the role of 5-ALA fluorescence in LGG surgery and the influence of AEDs on visible fluorescence.Patients and Methods: Patients with resection of a newly diagnosed suspected LGG after 5-ALA (25 mg/kg) administration were initially included. During surgery, the presence of visible fluorescence (none, mild, moderate, or bright) within the tumor and intratumoral fluorescence homogeneity (diffuse or focal) were analyzed. Tissue samples from fluorescing and/or non-fluorescing areas within the tumor and/or the assumed tumor border were collected for histopathological analysis (WHO tumor diagnosis, cell density, and proliferation rate). Only patients with diagnosis of LGG after surgery remained in the final study cohort. In each patient, the potential preoperative intake of AEDs was investigated.Results: Altogether, 27 patients with a histopathologically confirmed LGG (14 diffuse astrocytomas, 6 oligodendrogliomas, 4 pilocytic astrocytomas, 2 gemistocytic astrocytomas, and one desmoplastic infantile ganglioglioma) were finally included. Visible fluorescence was detected in 14 (52%) of 27. In terms of fluorescence homogeneity (n = 14), 7 tumors showed diffuse fluorescence, while in 7 gliomas focal fluorescence was noted. Cell density (p = 0.03) and proliferation rate (p = 0.04) was significantly higher in fluorescence-positive than in fluorescence-negative samples. Furthermore, 15 (56%) of 27 patients were taking AEDs before surgery. Of these, 11 patients (73%) showed no visible fluorescence. In contrast, 10 (83%) of 12 patients without prior AEDs intake showed visible fluorescence. Thus, visible fluorescence was significantly more common in patients without AEDs compared to patients with preoperative AED intake (OR = 0,15 (CI 95% 0.012–1.07), p = 0.046).Conclusions: Our study shows a markedly higher rate of visible fluorescence in a series of LGGs compared to current literature. According to our preliminary data, preoperative intake of AEDs seems to reduce the presence of visible fluorescence in such tumors and should thus be taken into account in the clinical setting

Adipose-Derived Stem Cells Stimulate Regeneration of Peripheral Nerves: BDNF Secreted by These Cells Promotes Nerve Healing and Axon Growth De Novo

Transplantation of adipose-derived mesenchymal stem cells (ASCs) induces tissue regeneration by accelerating the growth of blood vessels and nerve. However, mechanisms by which they accelerate the growth of nerve fibers are only partially understood. We used transplantation of ASCs with subcutaneous matrigel implants (well-known in vivo model of angiogenesis) and model of mice limb reinnervation to check the influence of ASC on nerve growth. Here we show that ASCs stimulate the regeneration of nerves in innervated mice's limbs and induce axon growth in subcutaneous matrigel implants. To investigate the mechanism of this action we analyzed different properties of these cells and showed that they express numerous genes of neurotrophins and extracellular matrix proteins required for the nerve growth and myelination. Induction of neural differentiation of ASCs enhances production of brain-derived neurotrophic factor (BDNF) as well as ability of these cells to induce nerve fiber growth. BDNF neutralizing antibodies abrogated the stimulatory effects of ASCs on the growth of nerve sprouts. These data suggest that ASCs induce nerve repair and growth via BDNF production. This stimulatory effect can be further enhanced by culturing the cells in neural differentiation medium prior to transplantation

An Inducible and Reversible Mouse Genetic Rescue System

Inducible and reversible regulation of gene expression is a powerful approach for uncovering gene function. We have established a general method to efficiently produce reversible and inducible gene knockout and rescue in mice. In this system, which we named iKO, the target gene can be turned on and off at will by treating the mice with doxycycline. This method combines two genetically modified mouse lines: a) a KO line with a tetracycline-dependent transactivator replacing the endogenous target gene, and b) a line with a tetracycline-inducible cDNA of the target gene inserted into a tightly regulated (TIGRE) genomic locus, which provides for low basal expression and high inducibility. Such a locus occurs infrequently in the genome and we have developed a method to easily introduce genes into the TIGRE site of mouse embryonic stem (ES) cells by recombinase-mediated insertion. Both KO and TIGRE lines have been engineered for high-throughput, large-scale and cost-effective production of iKO mice. As a proof of concept, we have created iKO mice in the apolipoprotein E (ApoE) gene, which allows for sensitive and quantitative phenotypic analyses. The results demonstrated reversible switching of ApoE transcription, plasma cholesterol levels, and atherosclerosis progression and regression. The iKO system shows stringent regulation and is a versatile genetic system that can easily incorporate other techniques and adapt to a wide range of applications

Phenological shifts of abiotic events, producers and consumers across a continent

Ongoing climate change can shift organism phenology in ways that vary depending on species, habitats and climate factors studied. To probe for large-scale patterns in associated phenological change, we use 70,709 observations from six decades of systematic monitoring across the former Union of Soviet Socialist Republics. Among 110 phenological events related to plants, birds, insects, amphibians and fungi, we find a mosaic of change, defying simple predictions of earlier springs, later autumns and stronger changes at higher latitudes and elevations. Site mean temperature emerged as a strong predictor of local phenology, but the magnitude and direction of change varied with trophic level and the relative timing of an event. Beyond temperature-associated variation, we uncover high variation among both sites and years, with some sites being characterized by disproportionately long seasons and others by short ones. Our findings emphasize concerns regarding ecosystem integrity and highlight the difficulty of predicting climate change outcomes. The authors use systematic monitoring across the former USSR to investigate phenological changes across taxa. The long-term mean temperature of a site emerged as a strong predictor of phenological change, with further imprints of trophic level, event timing, site, year and biotic interactions.Peer reviewe

Chronicles of nature calendar, a long-term and large-scale multitaxon database on phenology

We present an extensive, large-scale, long-term and multitaxon database on phenological and climatic variation, involving 506,186 observation dates acquired in 471 localities in Russian Federation, Ukraine, Uzbekistan, Belarus and Kyrgyzstan. The data cover the period 1890-2018, with 96% of the data being from 1960 onwards. The database is rich in plants, birds and climatic events, but also includes insects, amphibians, reptiles and fungi. The database includes multiple events per species, such as the onset days of leaf unfolding and leaf fall for plants, and the days for first spring and last autumn occurrences for birds. The data were acquired using standardized methods by permanent staff of national parks and nature reserves (87% of the data) and members of a phenological observation network (13% of the data). The database is valuable for exploring how species respond in their phenology to climate change. Large-scale analyses of spatial variation in phenological response can help to better predict the consequences of species and community responses to climate change.Peer reviewe