The role of physical culture in developing healthy lifestyles

CrossFit is today one of the fastest growing popularity trend in fitnessКроссфит является сегодня одним из наиболее быстро набирающих популярность направлений в фитнес

Intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphism

In 178 patients with different clinical forms of pulmonary tuberculosis carried out pharmacogenetic testing to determine gene polymorphism glutathione S-transferase system (GSTM1, GSTT1). Estimated the severity and duration of clinical manifestations of the syndrome of intoxication, depending on the gene polymorphism of glutathione S-transferase system (GSTM1, GSTT1). It was found that the combination of “zero” to develop genotypes GSTM1 and GSTT1 enzyme is a predictor of the severity and duration of symptoms of intoxication persisting

Nonlinear material and ionic transport through membrane nanotubes

Membrane nanotubes (NTs) and their networks play an important role in intracellular membrane transport and intercellular communications. The transport characteristics of the NT lumen resemble those of conventional solid-state nanopores. However, unlike the rigid pores, the soft membrane wall of the NT can be deformed by forces driving the transport through the NT lumen. This intrinsic coupling between the NT geometry and transport properties remains poorly explored. Using synchronized fluorescence microscopy and conductance measurements, we revealed that the NT shape was changed by both electric and hydrostatic forces driving the ionic and solute fluxes through the NT lumen. Far from the shape instability, the strength of the force effect is determined by the lateral membrane tension and is scaled with membrane elasticity so that the NT can be operated as a linear elastic sensor. Near shape instabilities, the transport forces triggered large-scale shape transformations, both stochastic and periodic. The periodic oscillations were coupled to a vesicle passage along the NT axis, resembling peristaltic transport. The oscillations were parametrically controlled by the electric field, making NT a highly nonlinear nanofluidic circuitry element with biological and technological implications.This work was partially supported by NIGMS of the National Institutes of Health under award R01GM121725, RYC-2014-01419 to A.V.S.; Spanish Ministry of Science, Innovation and Universities grants PGC2018-099971-B-I00 and EUR2019-103830 to A.V.S.; Basque Government grant IT1270-19; and the Ministry of Science and Higher Education of the Russian Federation to P.I.K. and G.T.R

Thermograms of High-Frequency Capacitive Discharge Between Solid and Liquid Electrodes

© 2018, Pleiades Publishing, Inc. Abstract: We present the experimental results on thermograms and plots of temperature distributions along the streamer and spark discharges in a high-frequency capacitive field between solid and liquid electrodes for different electrode geometries

СИНДРОМ ИНТОКСИКАЦИИ У БОЛЬНЫХ ТУБЕРКУЛЕЗОМ ЛЕГКИХ В ЗАВИСИМОСТИ ОТ ПОЛИМОРФИЗМА ГЕНОВ СИСТЕМЫ ГЛУТАТИОНТРАНСФЕРАЗ

In 178 patients with different clinical forms of pulmonary tuberculosis carried out pharmacogenetic testing to determine gene polymorphism glutathione S-transferase system (GSTM1, GSTT1). Estimated the severity and duration of clinical manifestations of the syndrome of intoxication, depending on the gene polymorphism of glutathione S-transferase system (GSTM1, GSTT1). It was found that the combination of “zero” to develop genotypes GSTM1 and GSTT1 enzyme is a predictor of the severity and duration of symptoms of intoxication persisting.У 178 пациентов с различными клиническими формами туберкулеза легких выполнено фармакогенетическое тестирование для определения полиморфизма генов системы глутатионтрансфераз (GSTM1, GSTT1). Оценена выраженность и длительность клинических проявлений синдрома интоксикации в зависимости от полиморфизма генов системы глутатионтрансфераз (GSTM1, GSTT1). Установлено, что комбинация «нулевых» генотипов по выработке ферментов GSTM1 и GSTT1 является предиктором выраженных и длительно сохраняющихся симптомов интоксикации

Isolation of two strains of West Nile virus during an outbreak in southern Russia, 1999.

From July to September 1999, a widespread outbreak of meningoencephalitis associated with West Nile virus (Flavivirus, Flaviviridae) occurred in southern Russia, with hundreds of cases and dozens of deaths. Two strains of West Nile virus isolated from patient serum and brain-tissue samples reacted in hemagglutination-inhibition and neutralization tests with patients' convalescent-phase sera and immune ascites fluid from other strains of West Nile virus