The Economic Impact of the University of Arkansas

As the state’s flagship institution of higher education, the University of Arkansas delivers a significant economic impact to Arkansas. In 2018, an impact in excess of $2.2 billion came from the University via operations, construction, technology transfer, student expenditures, and visitor spending. The University of Arkansas has a substantial influence on the direction of the state’s economy by fulfilling its land-grant mission of developing human capital, growing ideas, and transmitting knowledge to the public

The Economic Impact of the University of Arkansas

As the state’s flagship institution of higher education, the University of Arkansas delivers a significant economic impact to Arkansas. In 2018, an impact in excess of $2.2 billion came from the University via operations, construction, technology transfer, student expenditures, and visitor spending. The University of Arkansas has a substantial influence on the direction of the state’s economy by fulfilling its land-grant mission of developing human capital, growing ideas, and transmitting knowledge to the public

Effects of Corn Processing Method and Crude Protein Level with the Inclusion of Wet Corn Gluten Feed on Finishing Steer Performance

Three hundred twenty crossbred steer calves were used to evaluate corn processing method and crude protein level in finishing diets that included wet corn gluten feed. There was no response due to crude protein level (14 vs 15%) observed in this trial. As corn processing method became more intensive (fine-grinding, high-moisture ensiling, and steam-flaking corn) compared to dry-rolling, daily intake was reduced. Daily gain was similar across corn processing methods. Feed efficiency and cost of gain improved as corn processing method intensity increased

Using beet pulp to adapt cattle to finishing diets compared to traditional grain adaptation with alfalfa hay

A study was conducted to compare grain adaptation programs using beet pulp (BP) to traditional grain adaptation with alfalfa hay (AH). Yearling crossbred steers (n = 232; BW = 326 ± 14.5 kg) were separated into 3 weight blocks, stratified by BW, and assigned randomly, within strata, to 18 feedlot pens, with 12 or 13 steers per pen. Treatments were imposed during grain adaptation (21 d) using 3 grain adaptation programs. Within each grain adaptation program, 4 step rations were fed for 3, 4, 7, and 7 d. Each program increased dry-rolled corn inclusion while roughage inclusion decreased. In the control treatment (CON), AH inclusion decreased from 46 to 6% and pressed BP (24% DM) was held constant at 6% in all step rations. Beet pulp adaptation programs included a low BP treatment (LOBP) where BP was decreased from 18 to 6% and AH from 34 to 6% or a high BP treatment (HIBP) in which both BP and AH were decreased from 26 to 6%. On d 22 through the remainder of the finishing period cattle were fed a common diet (62% dry rolled corn, 20% wet distillers grains with solubles, 6% AH, 6% BP, 0.25% urea, and 5.75% liquid supplement DM basis). During grain adaptation, cattle fed CON tended (P = 0.07 for overall F test, P = 0.02 for mean comparison) to have greater DMI than HIPB and LOPB was intermediate (9.9, 9.5, and 9.7 kg, respectively). Gain and G:F were not different (P \u3e 0.19) among treatments during the grain adaptation period. However, based off of carcass adjusted final BW, steers adapted using HIBP and LOBP tended (P = 0.07 for overall F-test, P = 0.04 for mean comparison) to have greater ADG compared with CON (1.65, 1.72, and 1.73 kg, respectively). Overall G:F was not different (P = 0.11) among treatments. Dry matter intakes were not different across all treatments (P = 0.58). Carcass characteristics were not affected by adaptation method (P \u3e 0.31). Replacing up to 50% of AH with BP during grain adaptation increased ADG and may be used as an alternative to conventional adaptation programs

Association of Myostatin on Performance and Carcass Traits in Crossbred Cattle

Calf-fed steers and yearling heifersgenotyped as homozygous active, heterozygous, or homozygous inactive for myostatin were used to evaluate performance and carcass traits from Piedmontese influenced cattle. Homozygous inactive steers had similar ADG, lower DMI and lower F:G when compared to steers influenced by active myostatin. Steers and heifers with inactive myostatin showed similar trends in carcass traits producing larger LM area, greater dressing percentages and leaner carcasses. Similar ADG, lower DMI, and improved F:G were observed for homozygous inactive compared to homozygous active steers. Cattle with inactive myostatin require more days on feed than homozygous active cattle to reach similar live BW and 12th rib fat endpoints

De novo design of bioactive protein switches.

Allosteric regulation of protein function is widespread in biology, but is challenging for de novo protein design as it requires the explicit design of multiple states with comparable free energies. Here we explore the possibility of designing switchable protein systems de novo, through the modulation of competing inter- and intramolecular interactions. We design a static, five-helix 'cage' with a single interface that can interact either intramolecularly with a terminal 'latch' helix or intermolecularly with a peptide 'key'. Encoded on the latch are functional motifs for binding, degradation or nuclear export that function only when the key displaces the latch from the cage. We describe orthogonal cage-key systems that function in vitro, in yeast and in mammalian cells with up to 40-fold activation of function by key. The ability to design switchable protein functions that are controlled by induced conformational change is a milestone for de novo protein design, and opens up new avenues for synthetic biology and cell engineering

Association of Myostatin on Performance and Carcass Traits in Crossbred Cattle

Calf-fed steers and yearling heifersgenotyped as homozygous active, heterozygous, or homozygous inactive for myostatin were used to evaluate performance and carcass traits from Piedmontese influenced cattle. Homozygous inactive steers had similar ADG, lower DMI and lower F:G when compared to steers influenced by active myostatin. Steers and heifers with inactive myostatin showed similar trends in carcass traits producing larger LM area, greater dressing percentages and leaner carcasses. Similar ADG, lower DMI, and improved F:G were observed for homozygous inactive compared to homozygous active steers. Cattle with inactive myostatin require more days on feed than homozygous active cattle to reach similar live BW and 12th rib fat endpoints

Association of Inactive Myostatin in Piedmontese-Influenced Steers and Heifers on Performance and Carcass Traits at Different Endpoints

Performance and carcass traits were evaluated using Piedmontese-influenced calf-fed steers and yearling heifers genotyped for zero, one, or two copies (homozygous active, heterozygous, or homozygous inactive, respectively) of the inactive myostatin allele. Steers and heifers had similar responses across genotypes in performance and carcass traits evaluated at different endpoints. Inactive myostatin decreased DMI, final BW (live), and ADG (live). Increased dressing percentage resulted in increased carcass-adjusted ADG and improved feed conversion for cattle with inactive myostatin. Cattle with inactive myostatin are leaner with larger LM area when finished to equal carcass weight

Clotting activity of polyphosphate-functionalized silica nanoparticles

We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP-functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP-SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP-SNP even retains its clotting function at ambient temperature. The polyP-SNP system has the potential to significantly improve trauma-treatment protocols and outcomes in hospital and prehospital settings

Relationship of Race/Ethnicity and Survival after Single Umbilical Cord Blood Transplantation for Adults and Children with Leukemia and Myelodysplastic Syndromes

The relationship of race/ethnicity with outcomes of umbilical cord blood transplantation (UCBT) is not well known. We analyzed the association between race/ethnicity and outcomes of unrelated single UCBT for leukemia and myelodysplastic syndromes. Our retrospective cohort study consisted of 885 adults and children (612 whites, 145 blacks, and 128 Hispanics) who received unrelated single UCBT for leukemia and myelodysplastic syndromes between 1995 and 2006 and were reported to the Center for International Blood and Marrow Transplant Research. A 5-6/6 HLA-matched unit with a total nucleated cell count infused of ≥2.5 × 107/kg was given to 40% white and 42% Hispanic, but only 21% black patients. Overall survival at 2 years was 44% for whites, 34% for blacks, and 46% for Hispanics (P = .008). In multivariate analysis adjusting for patient, disease, and treatment factors (including HLA match and cell dose), blacks had inferior overall survival (relative risk of death, 1.31; P = .02), whereas overall survival of Hispanics was similar (relative risk, 1.03; P = .81) to that of whites. For all patients, younger age, early-stage disease, use of units with higher cell dose, and performance status ≥80 were independent predictors of improved survival. Black patients and white patients infused with well-matched cords had comparable survival; similarly, black and white patients receiving units with adequate cell dose had similar survival. These results suggest that blacks have inferior survival to whites after single UCBT, but outcomes are improved when units with a higher cell dose are used