New markers and linkage data

New markers and linkage dat

New isogenic wild types in N. crassa

New isogenic wild types in N. crass

Strings And Non-Topological Solitons

We have numerically calculated topological andnon-topological solitons in two spatial dimensions with Chern-Simons term. Their quantum stability, as well as that of the Maxwell vortex, is analyzed by means of bounce instantons which involve three-dimensional strings and non-topological solitons.Comment: 12 pages. 5 figure

Observed Limits on Charge Exchange Contributions to the Diffuse X-ray Background

We present a high resolution spectrum of the diffuse X-ray background from 0.1 to 1 keV for a ~1 region of the sky centered at l=90, b=+60 using a 36-pixel array of microcalorimeters flown on a sounding rocket. With an energy resolution of 11 eV FWHM below 1 keV, the spectrum's observed line ratios help separate charge exchange contributions originating within the heliosphere from thermal emission of hot gas in the interstellar medium. The X-ray sensitivity below 1 keV was reduced by about a factor of four from contamination that occurred early in the flight, limiting the significance of the results. The observed centroid of helium-like O VII is 568+2-3 eV at 90% confidence. Since the centroid expected for thermal emission is 568.4 eV while for charge exchange is 564.2 eV, thermal emission appears to dominate for this line complex, consistent with much of the high-latitude O VII emission originating in 2-3 x 10^6 K gas in the Galactic halo. On the other hand, the observed ratio of C VI Ly gamma to Ly alpha is 0.3+-0.2. The expected ratios are 0.04 for thermal emission and 0.24 for charge exchange, indicating that charge exchange must contribute strongly to this line and therefore potentially to the rest of the ROSAT R12 band usually associated with 10^6 K emission from the Local Hot Bubble. The limited statistics of this experiment and systematic uncertainties due to the contamination require only >32% thermal emission for O VII and >20% from charge exchange for C VI at the 90% confidence level. An experimental gold coating on the silicon substrate of the array greatly reduced extraneous signals induced on nearby pixels from cosmic rays passing through the substrate, reducing the triggered event rate by a factor of 15 from a previous flight of the instrument.Comment: 14 pages, 7 figures, to be published in Ap

Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes.

Factor structure analyses have revealed the presence of specific biological system markers in healthy humans and diseases. However, this type of approach in very old persons and in type 2 diabetes (T2DM) is lacking. A total sample of 2,137 Italians consisted of two groups: 1,604 healthy and 533 with T2DM. Age (years) was categorized as adults (≤65), old (66-85), oldest old (>85-98) and centenarians (≥99). Specific biomarkers of routine haematological and biochemical testing were tested across each age group. Exploratory factorial analysis (EFA) by principal component method with Varimax rotation was used to identify factors including related variables. Structural equation modelling (SEM) was applied to confirm factor solutions for each age group. EFA and SEM identified specific factor structures according to age in both groups. An age-associated reduction of factor structure was observed from adults to oldest old in the healthy group (explained variance 60.4% vs 50.3%) and from adults to old in the T2DM group (explained variance 57.4% vs 44.2%). Centenarians showed three-factor structure similar to those of adults (explained variance 58.4%). The inflammatory component became the major factor in old group and was the first one in T2DM. SEM analysis in healthy subjects suggested that the glucose levels had an important role in the oldest old. Factorial structure change during healthy ageing was associated with a decrease in complexity but showed an increase in variability and inflammation. Structural relationship changes observed in healthy subjects appeared earlier in diabetic patients and later in centenarians

Xmm-Newton Observations of the Diffuse X-ray Background

We analyzed two XMM-Newton observations in the direction of the high density, high latitude, neutral hydrogen cloud MBM20 and of a nearby low density region that we called the Eridanus hole. The cloud MBM20 is at a distance evaluated between 100 and 200 pc from the Sun and its density is sufficiently high to shield about 75% of the foreground emission in the 3/4 keV energy band.The combination of the two observations makes possible an evaluation of the OVII and OVIII emission both for the foreground component due to the Local Bubble,and the background one, due primary to the galactic halo.The two observations are in good agreement with each other and with ROSAT observations of the same part of the sky and the OVII and OVIII fluxes are OVII=3.89+/-0.56 photons cm^-2 s^-1 sr^-1, OVIII=0.68+/-0.24 photons cm^-2 s^-1 sr^-1 for MBM20 and OVII=7.26+/-0.34 photons cm^-2 s^-1 sr^-1,OVIII=1.63+/-0.17 photons cm^-2 s^-1 sr^-1 for the Eridanus hole. The spectra are in agreement with a simple three component model, one unabsorbed and one absorbed plasma component, and a power law, without evidence for any strong contamination from ion exchange in the solar system. Assuming that the two plasma components are in thermal equilibrium we obtain a temperature of 0.096 keV for the foreground component and 0.197 keV for the background one. Assuming the foreground component is due solely to Local Bubble emission we obtain a lower and upper limit for the plasma density of 0.0079 cm^-3 and 0.0095 cm^-3 and limits of 16,200 cm^-3 K and 19,500 cm^-3 K for the plasma pressure, in good agreement with theoretical predictions. Similarly, assuming that the absorbed plasma component is due to Galactic halo emission, we obtain a plasma density ranging from 0.0009 cm^-3 to 0.0016 cm^-3, and a pressure ranging from 3.0*10^3 to 6.7*10^3 cm^-3 K.Comment: 31 pages, 5 figures, Accepted for publication in Ap

DXL: a sounding rocket mission for the study of solar wind charge exchange and local hot bubble X-ray emission

The Diffuse X-rays from the Local galaxy (DXL) mission is an approved sounding rocket project with a first launch scheduled around December 2012. Its goal is to identify and separate the X-ray emission generated by solar wind charge exchange from that of the local hot bubble to improve our understanding of both. With 1,000 cm2 proportional counters and grasp of about 10 cm2 sr both in the 1/4 and 3/4 keV bands, DXL will achieve in a 5-minute flight what cannot be achieved by current and future X-ray satellites.Comment: 15 Pages, 5 figures. Accepted for publication on Experimental Astronom

Early

Arthritis Rheum. 2004 Dec;50(12):3934-40. Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis: lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial. Houssiau FA, Vasconcelos C, D'Cruz D, Sebastiani GD, de Ramon Garrido E, Danieli MG, Abramovicz D, Blockmans D, Mathieu A, Direskeneli H, Galeazzi M, Gül A, Levy Y, Petera P, Popovic R, Petrovic R, Sinico RA, Cattaneo R, Font J, Depresseux G, Cosyns JP, Cervera R. Université Catholique de Louvain, Brussels, Belgium. [email protected] Abstract OBJECTIVE: In the Euro-Lupus Nephritis Trial (ELNT), 90 patients with lupus nephritis were randomly assigned to a high-dose intravenous cyclophosphamide (IV CYC) regimen (6 monthly pulses and 2 quarterly pulses with escalating doses) or a low-dose IV CYC regimen (6 pulses of 500 mg given at intervals of 2 weeks), each of which was followed by azathioprine (AZA). After a median followup of 41 months, a difference in efficacy between the 2 regimens was not observed. The present analysis was undertaken to extend the followup and to identify prognostic factors. METHODS: Renal function was prospectively assessed quarterly in all 90 patients except 5 who were lost to followup. Survival curves were derived using the Kaplan-Meier method. RESULTS: After a median followup of 73 months, there was no significant difference in the cumulative probability of end-stage renal disease or doubling of the serum creatinine level in patients who received the low-dose IV CYC regimen versus those who received the high-dose regimen. At long-term followup, 18 patients (8 receiving low-dose and 10 receiving high-dose treatment) had developed permanent renal impairment and were classified as having poor long-term renal outcome. We demonstrated by multivariate analysis that early response to therapy at 6 months (defined as a decrease in serum creatinine level and proteinuria <1 g/24 hours) was the best predictor of good long-term renal outcome. CONCLUSION: Long-term followup of patients from the ELNT confirms that, in lupus nephritis, a remission-inducing regimen of low-dose IV CYC followed by AZA achieves clinical results comparable with those obtained with a high-dose regimen. Early response to therapy is predictive of good long-term renal outcome. PMID: 15593207 [PubMed - indexed for MEDLINE

The Microcalorimeter Arrays for a Rhenium Experiment (MARE): a next-generation calorimetric neutrino mass experiment

Neutrino oscillation experiments have proved that neutrinos are massive particles, but can't determine their absolute mass scale. Therefore the neutrino mass is still an open question in elementary particle physics. An international collaboration is growing around the project of Microcalorimeter Arrays for a Rhenium Experiment (MARE) for directly measuring the neutrino mass with a sensitivity of about 0.2eV/c2. Many groups are joining their experiences and technical expertise in a common effort towards this challenging experiment. We discuss the different scenarios and the impact of MARE as a complement of KATRIN.Comment: 3 pages, 1 figure Nucl. Instr. Meth. A, proceedings of LTD11 workshop, Tokyo 200