DIGITAL EDUCATIONAL ENVIRONMENT AS A TOOL OF SYSTEM CHANGES IN THE TEACHER’S PROFESSIONAL ACTIVITY

Purpose: Social and cultural prerequisites of Russia’s transition to an open information society have predetermined new requirements for graduates of modern educational organizations, ready for communicative activities in a digital educational environment. Informatization of education is characterized by increasing virtualization of the educational process and, as a consequence, the predominance of fragmented thinking, and increase in the gap between traditional and innovative educational technologies. Methodology: The basis of the digital educational environment in the context of the use of knowledge management technologies can be specialized knowledge management systems that combine knowledge of related scientific disciplines, which should provide integration, accumulation, and support, as well as the organization of access to knowledge of the educational environment. A distinctive feature of the development of mankind at the present stage is the transition to information society in which information and information processes are becoming one of the most important components of human life and society. Result: The development of the global process of informatization of society leads to the formation of not only the new information environment for people but also new, information way of their life and professional activities. Many researchers as the most acute problem of modern education called the mismatch of software, including for educational purposes, to high technical characteristics of computers, resulting in extremely low efficiency of computer use in training. Critically assessing the effectiveness of the existing software of the educational process and the ways of its development, we see the prospects for a radical change in the situation in the orientation to the use of knowledge management technologies that use software products that can be changed, adapting to the needs of the user and, in particular, to the didactic tasks of training. Applications: This research can be used for universities, teachers, and students. Novelty/Originality: In this research, the model of Digital Educational Environment as a Tool of System Changes in the Teacher’s Professional Activity is presented in a comprehensive and complete manner

The effect of hydrogen on strain hardening and fracture mechanism of high-nitrogen austenitic steel

High-nitrogen austenitic steels are perspective materials for an electron-beam welding and for producing of wear-resistant coatings, which can be used for application in aggressive atmospheres. The tensile behavior and fracture mechanism of high-nitrogen austenitic steel Fe-20Cr-22Mn-1.5V-0.2C-0.6N (in wt.%) after electrochemical hydrogen charging for 2, 10 and 40 hours have been investigated. Hydrogenation of steel provides a loss of yield strength, uniform elongation and tensile strength. The degradation of tensile properties becomes stronger with increase in charging duration - it occurs more intensive in specimens hydrogenated for 40 hours as compared to ones charged for 2-10 hours. Fracture analysis reveals a hydrogen-induced formation of brittle surface layers up to 6 [mu]m thick after 40 hours of saturation. Hydrogenation changes fracture mode of steel from mixed intergranular-transgranular to mainly transgranular one

Pulmonary Vascular Thrombosis in COVID-19: Clinical and Morphological Parallels

Aim. We aimed to study the histological and thrombotic changes in lung vessels in patients who died with COVID-19, to access the correlation between anticoagulation therapy (ACT) and thrombotic events (TE), treatment results, clinical and laboratory patients' characteristics.Material and Methods. We retrospectively analyzed treatment results of patients hospitalized with COVID-19 and lung vessel samples of the deceased patients. Dynamic changes and highest levels of D-dimer and fibrinogen were studied in its correlation with the disease severity according to SOFA score, computer tomographic (CT) results, lung, renal and hepatic dysfunction. The association between different doses of ACT and treatment results, laboratory indicators and thrombotic events was accessed. The histological lung vessels examination was performed using Martius Scarlet Blue (MSB)staining.Results. 313 patients were included in the study (61 patients died). The median age of hospitalized patients was 60 years (IQR 51-66 years). The frequency of the intravitallyconfirmed TE was 4,8%. The strong statistical association was revealed between D-dimer level and 3-4 points SOFA score, patients' mortality, oxygen support requirement, CT3-CT4 pneumonia, glomerular filtration rate and TE. There was no mortality in patients with D-dimer normal references, but in cases with three times elevation reached 13%, 48,5% - in cases with 3-6 times elevation and 64,6% - in cases with more than 6 times elevation. The strong statistical association was registered between fibrinogen and SOFA score, CT 3-4 pneumonia, patients' mortality. D-dimer and fibrinogen levels demonstrated weak correlation. There was no statistical correlation between prophylactic, intermediate and therapeutic ACT and D-dimer and fibrinogen levels, CT results, patients' mortality. MSBstaining was used in 36 deceased patients tissue samples. 1394 lung vessels were analyzed. Lung vessels thrombi persisted in samples of all 36 patients (100%). Vessels with the diameter 3,5-30 mm were thrombosed in 7%, with the diameter 0,034-0,84 mm - in 48%, with the diameter 0,85-3,4 mm - in 45%. The frequency of thrombi persisted 06 hours, 6-12 hours, 12-18hours, 18-24 hours and more than 24 hours was12%, 14%, 62%, 5% and 7% respectively.Conclusion. Thrombi of different ages from fresh to organized were observed in one third of lung vessels in all deceased patients. Lung vessels thrombosis plays an important role in pathogenesis and thanatogenesis of COVID-19. The D-dimer level correlates with lung, renal dysfunction, patients' mortality and doesn't show any correlation with ACT and can be accepted as a criterion of lung vessel thrombotic progression

Pathways of carbon and energy metabolism of the epibiotic community associated with the deep-sea hydrothermal vent shrimp Rimicaris exoculata

© The Authors, 2011. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS One 6 (2011): e16018, doi:10.1371/journal.pone.0016018.The shrimp Rimicaris exoculata dominates the faunal biomass at many deep-sea hydrothermal vent sites at the Mid-Atlantic Ridge. In its enlarged gill chamber it harbors a specialized epibiotic bacterial community for which a nutritional role has been proposed. We analyzed specimens from the Snake Pit hydrothermal vent field on the Mid-Atlantic Ridge by complementing a 16S rRNA gene survey with the analysis of genes involved in carbon, sulfur and hydrogen metabolism. In addition to Epsilon- and Gammaproteobacteria, the epibiotic community unexpectedly also consists of Deltaproteobacteria of a single phylotype, closely related to the genus Desulfocapsa. The association of these phylogenetic groups with the shrimp was confirmed by fluorescence in situ hybridization. Based on functional gene analyses, we hypothesize that the Gamma- and Epsilonproteobacteria are capable of autotrophic growth by oxidizing reduced sulfur compounds, and that the Deltaproteobacteria are also involved in sulfur metabolism. In addition, the detection of proteobacterial hydrogenases indicates the potential for hydrogen oxidation in these communities. Interestingly, the frequency of these phylotypes in 16S rRNA gene clone libraries from the mouthparts differ from that of the inner lining of the gill chamber, indicating potential functional compartmentalization. Our data show the specific association of autotrophic bacteria with Rimicaris exoculata from the Snake Pit hydrothermal vent field, and suggest that autotrophic carbon fixation is contributing to the productivity of the epibiotic community with the reductive tricarboxylic acid cycle as one important carbon fixation pathway. This has not been considered in previous studies of carbon fixation and stable carbon isotope composition of the shrimp and its epibionts. Furthermore, the co-occurrence of sulfur-oxidizing and sulfur-reducing epibionts raises the possibility that both may be involved in the syntrophic exchange of sulfur compounds, which could increase the overall efficiency of this epibiotic community.Funding was provided through NSF grant OCE-0452333 and the Alfried Krupp Wissenschaftskolleg Greifswald, Germany (SMS), the Max Planck Society, the German Research Foundation (DFG) Cluster of Excellence at Marum, and MOMARnet (ND, JMP), and IFM-GEOMAR (MH, JFI)

Neural network model for predicting the level of residual knowledge of the subjects of study

The task is to build a neural network model depending on residual knowledge the trainees with whom they come into the labor market. Neural network model makes it possible with enough precision to predict the level of professional training according to their individual abilities

Neural network model for predicting the level of residual knowledge of the subjects of study

The task is to build a neural network model depending on residual knowledge the trainees with whom they come into the labor market. Neural network model makes it possible with enough precision to predict the level of professional training according to their individual abilities

Digital educational environment as a tool of system changes in the teacher’s professional activity

© Latipov et al. Purpose: Social and cultural prerequisites of Russia’s transition to an open information society have predetermined new requirements for graduates of modern educational organizations, ready for communicative activities in a digital educational environment. Informatization of education is characterized by increasing virtualization of the educational process and, as a consequence, the predominance of fragmented thinking, and increase in the gap between traditional and innovative educational technologies. Methodology: The basis of the digital educational environment in the context of the use of knowledge management technologies can be specialized knowledge management systems that combine knowledge of related scientific disciplines, which should provide integration, accumulation, and support, as well as the organization of access to knowledge of the educational environment. A distinctive feature of the development of mankind at the present stage is the transition to information society in which information and information processes are becoming one of the most important components of human life and society. Result: The development of the global process of informatization of society leads to the formation of not only the new information environment for people but also new, information way of their life and professional activities. Many researchers as the most acute problem of modern education called the mismatch of software, including for educational purposes, to high technical characteristics of computers, resulting in extremely low efficiency of computer use in training. Critically assessing the effectiveness of the existing software of the educational process and the ways of its development, we see the prospects for a radical change in the situation in the orientation to the use of knowledge management technologies that use software products that can be changed, adapting to the needs of the user and, in particular, to the didactic tasks of training. Applications: This research can be used for universities, teachers, and students. Novelty/Originality: In this research, the model of Digital Educational Environment as a Tool of System Changes in the Teacher’s Professional Activity is presented in a comprehensive and complete manner

Aspects of pulse diagnostics, problems of preparation of human sphygmograms for computer processing

Modern methods of the pulse diagnostics were studied, the rationality of using different methods for pulse diagnostics was evaluated and the features of criteria interpretation of the pulse diagnostics methods and its scientific validation were revealed. The attempt of preparation of the pulse diagnostics data (human sphygmograms) for the further computer processing was made. The efficiency of preliminary results was assessed by the mathematical treatment of the sphygmograms. The attempt of prognostication of the reliability of possible variants of the mathematical treatment for the computer processing was made