10 research outputs found
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
- Abraham R.
- Adams H.
- Adams P.M.
- Adarmes-Gómez A.
- Adarmes-Gómez A.D.
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Ahmad S.
- Akinyemi R.O.
- Al-Chalabi A.
- Alarcón-Martín Emilio
- Albert M.S.
- Albin R.L.
- Alcolea Daniel
- Alegret Montserrat
- Ali M.
- Allen M.
- Allende I.R.
- Alonso M.D.
- Alonso M.D.
- Alvarez I.
- Alvarez L.
- Amer-Ferrer G.
- Amin N.
- Amouyel Philippe
- Anastasiou A.
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- Andrade V.
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- Belezhanska D.
- Bellenguez Céline
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- Below J.E.
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Get PDFCharacterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans
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Get PDF10.1186/s13195-015-0137-yAlzheimer's Research and Therapy715
Surgical Management of Metastatic Spinal Tumors
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No full textAmyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease
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No full textThe pathobiology of the osteoclast.
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No full textNeuroimaging in Alzheimer Disease
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- American Psychiatric Association.
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- The National Institute on Aging Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease.
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No full textAnaesthesia for Correction of Scoliosis in Children
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- Brazel P.W.
- Bridwell K.
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- 'SAGE Publications'
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No full textAlzheimer's disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 loci
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- Albert M.S.
- Albin R.L.
- Apostolova L.G.
- Arnold S.E.
- Baldwin C.T.
- Barber R.
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No full text10.1371/journal.pone.0148717PLoS ONE112e014871
Oxidative Stress in the Pathogenesis of Alzheimer’s Disease and Cerebrovascular Disease with Therapeutic Implications
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- Anamaria Jurcau
- Area-Gomez E.
- Arevalo M.A.
- Armulik A.
- Aurel Simion
- Austin S.A.
- Bais S.
- Bangen K.J.
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- Choi BR
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- de la Torre J.C.
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- Deane R.
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- Enomoto M.
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- Galasko D.R.
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- Gustafson D.R.
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- Laske C.
- Lazic D.
- Lee J-H.
- Levy-Lahad E.
- Leys D.
- Li F.
- Lithell H.
- Loeffler M.
- Lu B.
- Lu F.P.
- Luchsinger J.A.
- Lukic-Panin V.
- Manly J.J.
- Marcus D.L.
- Martinelli I.
- Martinez-Vicente M.
- Marwarha G.
- Maurer K.
- McIlroy S.P.
- Meldolesi J.
- Mielke M.M.
- Miller E.R.
- Mooradian A.D.
- Mori M.
- Murayama T.
- Nakajima K.
- Nelson A.R.
- Newcomer J.W.
- Nilsson S.E.
- Nogawa S.
- Oulès B.
- Packer L.
- Panza F.
- Pasinetti G.M.
- Perocchi F.
- Peters R.
- Porrini V.
- Pung Y.F.
- Quinlan C.L.
- Ray P.D.
- Rius-Pérez S.
- Roses A.D.
- Ruitenberg A.
- Samarghandian S.
- Sandoval H.
- Santos C.Y.
- Sarasija S.
- Sato M.
- Savva G.M.
- Scarmeas N.
- Schneider L.S.
- Seners P.
- Sevigny J.
- Sharma P.
- Sherrington R.
- Shi Y.
- Shoshan-Barmatz V.
- Siesjö B.K.
- Simion A.
- Skoog I.
- Smith R.A.
- Snow W.M.
- Snyder E.M.
- Supnet C.
- Talbot K.
- Terai K.
- Trushina E.
- Tu H.
- Tönnies E.
- Uno M.
- Valerio A.
- van Dyck C.H.
- Wang K.
- Wang S.
- Whiteman H.
- Winkler E.A.
- Xu J.
- Yaribeygi H.
- Yasar S.
- Zeng Y.
- Zhang F.
- Zhang X.
- Zhang Y.
- Zhao J.
- Zheng C.
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- Zlokovic B.V.
- Zlokovic B.V.
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- Field of study
No full textNew insights into the genetic etiology of Alzheimer’s disease and related dementias
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
No full textCharacterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022, The Author(s)
