Paediatricians’ referral preference of patients with embolised intravascular foreign bodies: a survey-based study

Background: Central line insertion is a routine procedure in medical practice. Dislodgement of lines into the vascular system is a rare complication. We noticed that paediatric health care providers (PHCP) contact the cardiac or general paediatric surgeon for extraction of dislodged lines more frequently than using the less invasive percutaneous approach.Aim: To study the referral preference of PHCP for patient with embolised intravascular foreign bodies.Methods: A questionnaire with three questions was distributed to PHCP of all paediatric subspecialties, including surgery, in two tertiary care centres. The questions were about the total number of patients seen with central line, experience with complications, and preferred specialty for removal of dislodged central lines.Results: The questionnaire was distributed to 128 professionals. The response rate was 79% (n101). Incomplete answers (n14) were excluded. The grades of responders were senior consultants 18%, junior consultants 38%, and residents 43%. Thirty nine percent of care providers experienced dislodgement or fragmentation of central lines. The majority (82%) prefer to refer the patients for surgical removal. Conclusions: Most PHCP in the selected hospitals prefer to refer patients with embolised foreign bodies in the vascular system for surgical removal. The local health policy should be updated for the use of the alternative percutaneous approach.Keywords: cardiac surgery; clinical practice; transcatheter retrieva

Antibacterial activity of Libyan Juniperus phoenicea L. leaves extracts against common nosocomial pathogens

In ancient times, botanical extracts were essential complementary method for microbial control. This study has been carried out to assess the antibacterial activities of methanol, acetone, and aqueous leaf extracts of Libyan Juniperus phoenicea L. against multidrug-resistant (MDR) clinical isolates (Staphylococcus aureus, S. haemolyticus, Pseudomonas aeruginosa, and Proteus mirabilis) using the agar well diffusion method. Based on the inhibition zone's diameter or appearance, the tested MDR bacteria were identified as susceptible, intermediate, or resistant using the standard criteria. The current study's findings showed that the concentration, type of solvent and bacterial species had a significant impact on the effectiveness of the plant extracts. Results of the study revealed that the methanol and acetone extracts demonstrated moderate to excellent antibacterial properties against all tested bacteria at all predefined concentrations (25, 50, 75, and 100%), with the zone of inhibition ranging from 15.66 to 27.66 mm. Among the tested solvents, the aqueous extract of J. phoenicea was the least effective against the clinical bacterial isolates. Further, the plant's leaf extracts were more effective against Gram-positive bacteria than Gram-negative bacterial pathogens. Most importantly, neither the aqueous extract nor the standard antibiotics inhibited P. aeruginosa, while the methanol and acetone extracts displayed remarkable inhibition zones against all tested bacteria. Consequently, the plant extracts (acetone and methanol) in this study may provide insightful information about the potential use of J. phoenicea leaves as a natural antibacterial agent, which could be used to combat antibiotic-resistant bacteria

Controller Energy management for hybrid renewable energy system

A new modified configuration for the stand-alone photovoltaic- wind ndash diesel generator system with and without battery to electrify a remote area household load in Egypt is presented. The displaying, reenactment, and operational control technique for the framework is produced. The created control intends to enhance the energy flow inside the framework, with the end goal that the heap is fulfilled autonomous on the varieties in insolation, the temperature and the wind speed. Additionally, it means to ensure the battery against overcharging or excessive discharging. Also, it means to secure the worldwide framework against the unpredictable excess or defict of the available energy

Efecto hepatoprotector del insaponificable de los aceites de oliva, linaza y sésamo contra la lesión hepática inducida por tetracloruro de carbono en ratas

In the present study, the hepatoprotective activity of the unsaponifiable matter (UNSAP) of olive oil, linseed, and sesame oils against CCl4-induced liver toxicity in rats was investigated. In a preliminary antioxidant study, UNSAP showed pronounced DPPH radical scavenging activity (IC50 6.2-10.8 mg/mL). The constituents of UNSAP were determined by GC-MS. The subcutaneous administration of CCl4, caused liver injury. The hepatoprotective effect of UNSAP was comparable to that of α-tocopherol, a standard antioxidant agent. The co-administration of the investigated UNSAP normalized the activities of serum marker enzymes, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Furthermore, the serum alkaline phosphatase (ALP) activity and hepatic malondialdehyde (MDA) level were found to be alleviated by pre-treatment with the UNSAP. A histopathological evaluation showed marked improvement in the liver of UNSAP- and α-Tocopherol-treated animals. The hepatoprotective effect could be attributed to the antioxidant characteristics of UNSAP.En el presente estudio, se investigó la actividad hepatoprotectora de la materia insaponificable (UNSAP) de los aceites de oliva, linaza y sésamo contra la toxicidad hepática inducida por CCl4 en ratas. En un estudio preliminar de antioxidantes, UNSAP mostró una pronunciada actividad de captación de radicales DPPH (IC50 6.2-10.8 mg / mL). Los constituyentes del UNSAP fueron determinados por GC-MS. La administración de CCl4, por vía subcutánea, causó lesión hepática. El efecto hepatoprotector del UNSAP fue comparable al del α-Tocoferol, un agente antioxidante estándar. La administración conjunta del UNSAP normalizó las actividades de las enzimas marcadoras séricas, alanina aminotransferasa (ALT) y aspartato aminotransferasa (AST). Además, se encontró que la actividad de la fosfatasa alcalina en suero (ALP) y el nivel de malondialdehído hepático (MDA) se mitigan con el tratamiento previo con UNSAP. La evaluación histopatológica mostró una mejoría notable en el hígado de los animales tratados con UNSAP y α-Tocopherol. El efecto hepatoprotector podría atribuirse a las características antioxidantes de UNSAP

Actividades antioxidantes, antiinflamatorias y citotóxicas de la fracción insaponificable de aceite de oliva virgen extra

The health benefits of olive oil are well-known. In this study, the unsaponifiable fraction of extra virgin olive oil (Unsap) was investigated for reducing power capacity, ferric reducing antioxidant power, fer-rous chelating activity and nitric oxide inhibition. The present study was also designed to evaluate the in vitro cytotoxic effect of the Unsap against human carcinoma cells. The anti-inflammatory potential of Unsap has been determined via the inhibition of Human Cyclooxygenases. The results showed that Unsap is efficient for ferric reducing antioxidant power and nitric oxide inhibition. Unsap has a selective effect as anti-inflammatory agent. The results showed moderate to good in vitro antitumor activities of Unsap against human liver, lung and pancreas cancer cells with IC50 ranging from 19.6 to 30.4 μg/mL and good selectivity index (≥ 2). In conclusion, Unsap represents a promising and safe antitumor and antioxidant material that supports the need for further investigation.Los beneficios para la salud del aceite de oliva son bien conocidos. En este estudio, se investigó la fracción insaponificable del aceite de oliva virgen extra (Insap) para reducir el poder antioxidante férrico, la actividad quelante ferrosa y la inhibición del óxido nítrico. El presente estudio también fue diseñado para evaluar el efecto citotóxico in vitro del Insap contra las células de carcinoma humano. La potencialidad antiinflamatoria del Insap se ha determinado mediante la inhibición de las ciclooxigenasas humanas. Los resultados mostraron que el Insap es eficiente para reducir el poder antioxidante férrico y la inhibición del óxido nítrico. El Insap tiene un efecto selectivo como agente antiinflamatorio. Los resultados mostraron actividades antitumorales in vitro del Insap de moderadas a buenas contra células de cáncer de hígado, pulmón y páncreas humano con una CI50 que varía de 19,6 a 30,4 μg/ml y por su buen índice de selectividad ( ≥ 2). En conclusión, el Insap contiene material antitumoral y antioxidante prometedor y seguro que será respaldado por investiga-ciones adicionales

Aegis: Privacy-Preserving Market for Non-Fungible Tokens

Non-fungible tokens (NFTs) are unique non-interchangeable digital assets verified and stored using blockchain technology. Quite recently, there has been a surging interest and adoption of NFTs, with sales exceeding \$10 billion in the third quarter of 2021. Given the public state of Blockchain, NFTs owners face a privacy problem. More precisely, an observer can trivially learn the whole NFT collections owned by an address. For some categories of NFTs like arts and game collectibles, owners can sell them for a profit. However, popular marketplaces trade NFTs using public auctions and direct offers. Hence, an observer can learn about the new owner and the NFT purchase price. To tackle those problems, we propose Aegis, a protocol that allows users to add privacy to their NFTs ownership. In Aegis, users can swap NFTs for payment amounts in fungible tokens while hiding the details (i.e., involved parties, the NFTs, and the payment amounts). One of the main properties of Aegis is its complete compatibility with existing NFT standards. We design Aegis by leveraging a zk-SNARK proof system and smart contracts. We build an open-source prototype and perform experiments to evaluate Aegis\u27s performance

Disaster management in industrial areas: Perspectives, challenges and future research

Purpose: In most countries, development, growth, and sustenance of industrial facilities are given utmost importance due to the influence in the socio-economic development of the country. Therefore, special economic zones, or industrial areas or industrial cities are developed in order to provide the required services for the sustained operation of such facilities. Such facilities not only provide a prolonged economic support to the country but it also helps in the societal aspects as well by providing livelihood to thousands of people. Therefore, any disaster in any of the facilities in the industrial area will have a significant impact on the population, facilities, the economy, and threatens the sustainability of the operations. This paper provides review of such literature that focus on theory and practice of disaster management in industrial cities. Design/methodology/approach: In the paper, content analysis method is used in order to elicit the insights of the literature available. The methodology uses search methods, literature segregation and developing the current knowledge on different phases of industrial disaster management. Findings: It is found that the research is done in all phases of disaster management, namely, preventive phase, reactive phase and corrective phase. The research in each of these areas are focused on four main aspects, which are facilities, resources, support systems and modeling. Nevertheless, the research in the industrial cities is insignificant. Moreover, the modeling part does not explicitly consider the nature of industrial cities, where many of the chemical and chemical processing can be highly flammable thus creating a very large disaster impact. Some research is focused at an individual plant and scaled up to the industrial cities. The modeling part is weak in terms of comprehensively analyzing and assisting disaster management in the industrial cities. Originality/value: The comprehensive review using content analysis on disaster management is presented here. The review helps the researchers to understand the gap in the literature in order to extend further research for disaster management in large scale industrial cities.Scopu

Impact of Nutritional Health Education on Knowledge and Practices of Mothers of Anemic Children in El Othmanyia Village – Egypt

BACKGROUND: In Egypt, more than one in four children suffers from some degree of anemia. AIM: This study was carried out to assess and improve the nutritional knowledge and risky nutritional habits of the mothers of anemic children aged 2–12 years old in El Othmanyia village. MATERIALS AND METHODS: An interventional study was conducted among anemic children aged 2–12 years old and their mothers in El Othmanyia village, Egypt. The study passed through three stages over 1 and ½ years; pre-interventional assessment of awareness (n = 350), educational interventions targeting anemic children and their mothers, and post-interventional evaluation of change in awareness and practice. RESULTS: The mean knowledge % score of mothers increased significantly after the intervention (82.2 ± 14.2 vs. 6.3 ± 5.8, respectively). Furthermore, the mean hemoglobin of the studied children increased significantly after the intervention (11.1 ± 0.7 vs. 10.5 ± 0.7). The percent of children with anemia decreased significantly from 100% to 40.3% after the intervention (p < 0.001). CONCLUSION: The knowledge and practices of mothers are moving in a desirable direction after the health education intervention. Hence, nutrition education is an appropriate, effective, and sustainable approach to combat iron deficiency anemia. Recommendations: A multiple interventional strategies between different ministries to set policies and guidelines that support the healthy nutritional behavior among children are recommended. &nbsp

An Efficient Micropayment Channel on Ethereum

Blockchain protocols for cryptocurrencies offer secure payment transactions, yet their throughput pales in comparison to centralized payment systems such as VISA. Moreover, transactions incur fees that relatively hinder the adoption of cryptocurrencies for simple daily payments. Micropayment channels are second layer protocols that allow efficient and nearly unlimited number of payments between parties at the cost of only two transactions, one to initiate it and the other one to close it. Typically, the de-facto approach for micropayment channels on Ethereum is to utilize digital signatures which incur a constant gas cost but still relatively high due to expensive elliptic curve operations. Recently, ElSheikh et al. have proposed a protocol that utilizes hash chain which scales linearly with the channel capacity and has a lower cost compared to the digital signature based channel up to a capacity of 1000 micropayments. In this paper, we improve even more and propose a protocol that scales logarithmically with the channel capacity. Furthermore, by utilizing a variant of Merkle tree, our protocol does not require the payer to lock the entire balance at the channel creation which is an intrinsic limitation with the current alternatives. To assess the efficiency of our protocol, we carried out a number of experiments, and the results prove a positive efficiency and an overall low cost. Finally, we release the source code for prototype on GitHub

Synthesis and studying the antitumor activity of novel 5-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thiones

The influence of the incorporation of 1,3,4-oxadiazole ring into 2-methyl-1H-benzimidazole derivatives producing a series of substituted 5(6)-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazoles on the antitumor activity was studied in this study. The antitumor activity of the new compounds was tested against breast cancer cell line MCF-7 and lung cancer cell line A549. S-5-(2-methyl-1H-benzo[d]imidazol-5-yl)-1,3,4-oxadiazol-2-yl 2-nitrobenzenesulfonothioate (9) showed potent activity against both MCF-7 and A549 cell lines. Whereas, compounds 7, 11-13 and 15-17 have moderate growth inhibitory activity on the two cell lines