Crest – Chemin de Chanterenard

Le diagnostic réalisé en décembre 2020 sur la parcelle ZI 636 de la commune de Crest (chemin de Chanterenard) a porté une surface de 1 937 m2, et a nécessité l’ouverture de cinq sondages mécaniques. Contrairement aux autres diagnostics réalisés dans ce secteur, la haute terrasse alluviale graveleuse Fx2, qui constitue localement le substrat « ancien », a été aperçue au cours de l’opération. Elle est ici constituée de galets essentiellement calcaires, liés entre eux par une matrice argilo-sabl..

Romans-sur-Isère – ZA des Chasses

Réalisé en août et septembre 2020, le diagnostic de la ZA des Chasses a porté sur une superficie de 85 371 m2. La séquence stratigraphique mise au jour à l’occasion des travaux est constituée de la succession de plusieurs niveaux sédimentaires, déjà observés pour la plupart lors des opérations d’archéologie préventive conduites dans ce secteur. La présence ponctuelle d’un recouvrement supérieur de la terrasse alluviale würmienne, dérivé du démantèlement des sols pédologiques, constitue toute..

Romans-sur-Isère – 9 rue Gaillard

Le diagnostic archéologique engagé au 9 rue Gaillard de la commune de Romans-sur-Isère n’a pas permis de recouper de structures, ni de relever d’artefacts antérieurs au xxe s. Les deux sondages ouverts à cette occasion ont livré une stratigraphie assez classique pour ce secteur de la ville, caractérisée en partie inférieure par un sol ferralitique brun-rouge, surmonté d’alluvions modernes issues des débordements de la Savasse. La partie supérieure de la séquence est marquée par un remblai ..

La sépulture protohistorique de la Métairie Grande à Laure-Minervois (Aude) (VIIe s. av. n. è.)

À Laure-Minervois, entre la Montagne Noire et l’Aude, la sépulture de la Métairie Grande constitue un nouvel ensemble funéraire à rattacher au faciès Grand Bassin I. L’abondant mobilier en céramique non tournée (cratères à col et pied hauts, coupes et coupelles hémisphériques) et une épingle en fer à tête enroulée permettent de situer cette découverte dans la première moitié du VIIe s. av. J.-C. Le dépôt sépulcral a été placé dans une fosse quadrangulaire dont la fouille a montré qu’elle devait être vide de tout sédiment lors de la condamnation de la sépulture.The Métarie Grande tomb at Laure-Minervois, situated between the Montagne Noire and l'Aude, constitutes a new funerary assemblage of the Grand Bassin I facies. The large hand-thrown ceramic assemblage (crater pottery with low and high necks and feet, hemispheric cups and bowls) an iron comb with a scrolled head, allows us to place this discovery in the first half of VIIth century BC. The deposit was placed in a quadrangular ditch and the excavation showed that this must have been emptied of all sediment prior to the burial

Monticello – E Stabielle

La fouille préventive de la parcelle B91 au lieu-dit E Stabielle a été réalisée en préalable à la construction d’un lotissement, entre décembre 2014 et mars 2015. Si quelques vestiges diffus étaient bien visibles à la surface du sol, les parcelles concernées par le diagnostic se situent à peine à une centaine de mètres à l’est et au nord de l’habitat Néolithique final de Listrella. La fouille a concerné une emprise de 1 300 m2 environ située en pied de versant sur un replat hérité d’un cône d..

Monticello – E Stabielle

La fouille préventive de la parcelle B91 au lieu-dit E Stabielle a été réalisée en préalable à la construction d’un lotissement, entre décembre 2014 et mars 2015. Si quelques vestiges diffus étaient bien visibles à la surface du sol, les parcelles concernées par le diagnostic se situent à peine à une centaine de mètres à l’est et au nord de l’habitat Néolithique final de Listrella. La fouille a concerné une emprise de 1 300 m2 environ située en pied de versant sur un replat hérité d’un cône d..

Age-adapted percentiles of measured glomerular filtration in healthy individuals:extrapolation to living kidney donors over 65 years

OBJECTIVES: Most data on glomerular filtration rate (GFR) originate from subjects <65 years old, complicating decision-making in elderly living kidney donors. In this retrospective multi-center study, we calculated percentiles of measured GFR (mGFR) in donors <65 years old and extrapolated these to donors ≥65 years old. METHODS: mGFR percentiles were calculated from a development cohort of French/Belgian living kidney donors <65 years (n=1,983), using quantiles modeled as cubic splines (two linear parts joining at 40 years). Percentiles were extrapolated and validated in an internal cohort of donors ≥65 years (n=147, France) and external cohort of donors and healthy subjects ≥65 years (n=329, Germany, Sweden, Norway, France, The Netherlands) by calculating percentages within the extrapolated 5th-95th percentile (P5-P95). RESULTS: Individuals in the development cohort had a higher mGFR (99.9 ± 16.4 vs. 86.4 ± 14 and 82.7 ± 15.5 mL/min/1.73 m(2)) compared to the individuals in the validation cohorts. In the internal validation cohort, none (0%) had mGFR below the extrapolated P5, 12 (8.2%) above P95 and 135 (91.8%) between P5-P95. In the external validation cohort, five subjects had mGFR below the extrapolated P5 (1.5%), 25 above P95 (7.6%) and 299 (90.9%) between P5-P95. CONCLUSIONS: We demonstrate that extrapolation of mGFR from younger donors is possible and might aid with decision-making in elderly donors

Admission criteria and management of critical care patients in a pandemic context: position of the Ethics Commission of the French Intensive Care Society, update of April 2021.

Intensive care unit professionals have experience in critical care and its proportionality, collegial decision-making, withholding or withdrawal of treatment deemed futile, and communication with patients' relatives. These elements rely on ethical values from which we must not deviate in a pandemic situation. The recommendations made by the Ethics Commission of the French Intensive Care Society reflect an approach of responsibility and solidarity towards our citizens regarding the potential impact of a pandemic on critical care resources in France, with the fundamental requirement of respect for human dignity and equal access to health care for all

Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa.

peer reviewed("[en] BACKGROUND: A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This equation has neither been validated outside USA nor compared with the new European Kidney Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in European cohorts. METHODS: Standardized creatinine and measured glomerular filtration rate (GFR) from the European EKFC cohorts (n = 13 856 including 6031 individuals in the external validation cohort), from France (n = 4429, including 964 Black Europeans), from Brazil (n = 100) and from Africa (n = 508) were used to test the performances of the equations. A matched analysis between White Europeans and Black Africans or Black Europeans was performed. RESULTS: In White Europeans (n = 9496), both the EKFC and LMREV equations outperformed CKD-EPIAS (bias of -0.6 and -3.2, respectively versus 5.0 mL/min/1.73 m², and accuracy within 30% of 86.9 and 87.4, respectively, versus 80.9%). In Black Europeans and Black Africans, the best performance was observed with the EKFC equation using a specific Q-value (= concentration of serum creatinine in healthy males and females). These results were confirmed in matched analyses, which showed that serum creatinine concentrations were different in White Europeans, Black Europeans and Black Africans for the same measured GFR, age, sex and body mass index. Creatinine differences were more relevant in males. CONCLUSION: In a European and African cohort, the performances of CKD-EPIAS remain suboptimal. The EKFC equation, using usual or dedicated population-specific Q-values, presents the best performance in the whole age range in the European and African populations included in this study.","[en] ",""

A Solve-RD ClinVar-based reanalysis of 1522 index cases from ERN-ITHACA reveals common pitfalls and misinterpretations in exome sequencing

Purpose Within the Solve-RD project (https://solve-rd.eu/), the European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies aimed to investigate whether a reanalysis of exomes from unsolved cases based on ClinVar annotations could establish additional diagnoses. We present the results of the “ClinVar low-hanging fruit” reanalysis, reasons for the failure of previous analyses, and lessons learned. Methods Data from the first 3576 exomes (1522 probands and 2054 relatives) collected from European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies was reanalyzed by the Solve-RD consortium by evaluating for the presence of single-nucleotide variant, and small insertions and deletions already reported as (likely) pathogenic in ClinVar. Variants were filtered according to frequency, genotype, and mode of inheritance and reinterpreted. Results We identified causal variants in 59 cases (3.9%), 50 of them also raised by other approaches and 9 leading to new diagnoses, highlighting interpretation challenges: variants in genes not known to be involved in human disease at the time of the first analysis, misleading genotypes, or variants undetected by local pipelines (variants in off-target regions, low quality filters, low allelic balance, or high frequency). Conclusion The “ClinVar low-hanging fruit” analysis represents an effective, fast, and easy approach to recover causal variants from exome sequencing data, herewith contributing to the reduction of the diagnostic deadlock