186 research outputs found
An edition of fourteen unpublished Greek documents from Roman and Byzantine Egypt.
SIGLEAvailable from British Library Document Supply Centre- DSC:D93927 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Towards A Liberating Eschatology. Imagining The End Of The World To Survive The âHorrors Of The Anthropoceneâ
First examining how capitalist realism and capitalist sorcery are suppressing the ability to think new futures through the manufacturing of what Pignarre and Stengers call infernal alternatives and how the fear of such alternatives limit the influence of tools such as the IPCC reports and the media in acknowledging the need for capitalism to be challenged in regards of climate change, this essay is an attempt to help âbreaking the spellâ, the common thought that âit is easier to imagine the end of the world than the end of capitalismâ.
The narrative of the Anthropocene and the cult-like belief in progress both rooted in the myth of human exceptionalism, are shown to play a determining role in denying the role of capitalism in climate change. In this context, acknowledging Earth as a living organism â Gaia â is perceived as quasi heretic and therefore, is systematically rejected.
Here I argue that Isabelle Stengersâ concept of âthe intrusion of Gaiaâ presenting Gaia (Earth) as a form of transcendence to be reckon with, should be taken seriously and be seen as posing the most real infernal alternative of all: if we fail to find a way to live in a more symbiotic way with our environment, humanity will not survive the horrors of the Anthropocene.
Finally, I suggest that to avoid the end of The World, âweâ, the moderns, need to accept, and imagine, the end of our world based on the old myth of human exceptionalism which has led us to alienate a large part of humanity. Only in doing so, will we be able to create a new people with the âbelief in the worldâ needed to acknowledge the âintrusion of Gaiaâ and able to generate events that elude capitalist sorceryâs control to survive the horrors of the Anthropocene
The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation
The vertebrate RECQL4 (RECQ4) gene is thought to be the ortholog of budding yeast SLD2. However, RecQL4 contains within its C-terminus a RecQ-like helicase domain, which is absent in Sld2. We established human pre-B lymphocyte Nalm-6 cells, in which the endogenous RECQL4 gene was homozygously targeted such that the entire C-terminus would not be expressed. The RECQL4(ÎC/ÎC) cells behaved like the parental cells during unperturbed DNA replication or after treatment with agents that induce stalling of DNA replication forks, such as hydroxyurea (HU). However, after exposure to ionizing radiation (IR), the RECQL4(ÎC/ÎC) cells exhibited hypersensitivity, inability to complete S phase and prematurely terminated or paused DNA replication forks. Deletion of BLM, a gene that also encodes a RecQ helicase, had the opposite phenotype; an almost wild-type response to IR, but hypersensitivity to HU. Targeting both R ECQL4 and BLM resulted in viable cells, which exhibited mostly additive phenotypes compared with those exhibited by the RECQL4(ÎC/ÎC) and the BLM(â /â ) cells. We propose that RecQL4 facilitates DNA replication in cells that have been exposed to I
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