BioCloud Search EnGene: Surfing Biological Data on the Cloud

The massive production and spread of biomedical data around the web introduces new challenges related to identify computational approaches for providing quality search and browsing of web resources. This papers presents BioCloud Search EnGene (BSE), a cloud application that facilitates searching and integration of the many layers of biological information offered by public large-scale genomic repositories. Grounding on the concept of dataspace, BSE is built on top of a cloud platform that severely curtails issues associated with scalability and performance. Like popular online gene portals, BSE adopts a gene-centric approach: researchers can find their information of interest by means of a simple “Google-like” query interface that accepts standard gene identification as keywords. We present BSE architecture and functionality and discuss how our strategies contribute to successfully tackle big data problems in querying gene-based web resources. BSE is publically available at: http://biocloud-unica.appspot.com/

The invariants of the Clifford groups

The automorphism group of the Barnes-Wall lattice L_m in dimension 2^m (m not 3) is a subgroup of index 2 in a certain ``Clifford group'' C_m (an extraspecial group of order 2^(1+2m) extended by an orthogonal group). This group and its complex analogue CC_m have arisen in recent years in connection with the construction of orthogonal spreads, Kerdock sets, packings in Grassmannian spaces, quantum codes, Siegel modular forms and spherical designs. In this paper we give a simpler proof of Runge's 1996 result that the space of invariants for C_m of degree 2k is spanned by the complete weight enumerators of the codes obtained by tensoring binary self-dual codes of length 2k with the field GF(2^m); these are a basis if m >= k-1. We also give new constructions for L_m and C_m: let M be the Z[sqrt(2)]-lattice with Gram matrix [2, sqrt(2); sqrt(2), 2]. Then L_m is the rational part of the mth tensor power of M, and C_m is the automorphism group of this tensor power. Also, if C is a binary self-dual code not generated by vectors of weight 2, then C_m is precisely the automorphism group of the complete weight enumerator of the tensor product of C and GF(2^m). There are analogues of all these results for the complex group CC_m, with ``doubly-even self-dual code'' instead of ``self-dual code''.Comment: Latex, 24 pages. Many small improvement

A supersymmetric matrix model: II. Exploring higher-fermion-number sectors

Continuing our previous analysis of a supersymmetric quantum-mechanical matrix model, we study in detail the properties of its sectors with fermion number F=2 and 3. We confirm all previous expectations, modulo the appearance, at strong coupling, of {\it two} new bosonic ground states causing a further jump in Witten's index across a previously identified critical 't Hooft coupling $\lambda_c$. We are able to elucidate the origin of these new SUSY vacua by considering the $\lambda \to \infty$ limit and a strong coupling expansion around it.Comment: 14 pages, 4 figure

Productivity of hired and family labour and determinants of technical inefficiency in Ghana's fish farms

This paper examines the productivity of hired and family labour and determinants of technical inefficiency of fish farms in Ghana. A modified Cobb-Douglas stochastic frontier production function which accounts for zero usage of family and hired labour is employed on cross-sectional data of 150 farmers collected in 2007. The results reveal that family labour, hired labour, feed, seed, land, other cost and extension visit have reasserting influence on fish farm production. Findings also show that family and hired labour used for fish farming production in Ghana may be equally productive. The combined effects of operational and farm specific factors (age, experience, land, gender, pond type and education) influence technical inefficiency although individual effects of some variables may not be significant. Mean technical efficiency is estimated to be 79 percent. Given the present state of technology and input level, the possibility of enhancing production can be achieved by reducing technical inefficiency by 21 percent through adoption of practices of the best fish farm. --Ghana,fish farms,technical inefficiency,hired and family labour,stochastic frontier.

Spine-sheath layer radiative interplay in subparsec-scale jets and the TeV emission from M87

Simple one-zone homogeneous synchrotron self-Compton models have severe difficulties in explaining the TeV emission observed in the radiogalaxy M87. Also the site of the TeV emission region is uncertain: it could be the unresolved jet close to the nucleus, analogously to what proposed for blazars, or an active knot, called HST-1, tens of parsec away. We explore the possibility that the TeV emission of M87 is produced in the misaligned subpc scale jet. We base our modelling on a structured jet, with a fast spine surrounded by a slower layer. In this context the main site responsible for the emission of the TeV radiation is the layer, while the (debeamed) spine accounts for the emission from the radio to the GeV band: therefore we expect a more complex correlation with the TeV component than that expected in one-zone scenarios, in which both components are produced by the same region. Observed from small angles, the spine would dominate the emission, with an overall Spectral Energy Distribution close to those of BL Lac objects with a synchrotron peak located at low energy (LBLs).Comment: 5 pages, 2 figures. Accepted for publication in MNRAS Letter

Essentials of Health Promotion in Children and Adolescents

Dargestellt werden die theoretischen Grundlagen für die Gesundheitsförderung bei Kindern und Jugendlichen. Ausgehend von einer kurzen Einbettung in die Rahmendisziplinen der Gesundheitspsychologie, Entwicklungspsychologie und Pädagogischen Psychologie, werden epidemiologische Befunde vorgestellt. Vor dem Hintergrund der Schwierigkeiten, die mit der Diagnostik gesundheitsrelevanter Aspekte bei Kindern und Jugendlichen verknüpft sind, werden Daten zum Gesundheitszustand, zum Gesundheitsverhalten, zu gesundheitsbezogenen Kognitionen und zu Belastungen und Ressourcen im Kindes- und Jugendalter dargestellt. Danach wird die Frage der Anwendung von Gesundheitsförderungsmaßnahmen in der Praxis behandelt, wobei zunächst auf die entscheidenden Institutionen und Settings, sodann auf Methoden und Strategien eingegangen wird. Abschließend werden Möglichkeiten und Grenzen der Gesundheitsförderung bei Kindern und Jugendlichen kritisch und zukunftsgerichtet diskutiert. (DIPF/Orig.

RBF approximation of large datasets by partition of unity and local stabilization

We present an algorithm to approximate large dataset by Radial Basis Function (RBF) techniques. The method couples a fast domain decomposition procedure with a localized stabilization method. The resulting algorithm can efficiently deal with large problems and it is robust with respect to the typical instability of kernel methods

Capacity analysis of suburban rail networks

As is well known, capacity evaluation and the identification of bottlenecks on rail networks are complex issues depending upon several technical elements. This is even more perceptible in metropolitan areas where different services (freight, long distance, metro/regional, etc.) are operated using the same limited infrastructures; as a consequence, these facilities may represent bottlenecks of the rail system since they are often highly utilized and congested. This paper tries to explore the issue of capacity evaluation of complex rail networks, proposing synthetic indicators and analyses for feasibility studies or strategic planning. The presented methodology suggests taking into account the main differences in infrastructure characteristics (e.g. single or double lines, signalling systems, terminus or passing stations, etc.) and rail services (e.g. diverse rolling stock, various frequencies, average distances and number of stops, etc.) in order to propose a general approach applicable for capacity analysis of a network as a whole, hence evaluating the utilization rate and the congestion on both lines and stations. To better explore and validate the methodology, an application to a line of the Naples’ suburban network is presented. The results confirm the applicability and effectiveness of the proposed approach; the outcomes indicate the capacity utilization rate of the considered facilities, pointing out likely bottlenecks and possible actions to improve the system efficiency

Neural Substrates of Chronic Pain in the Thalamocortical Circuit

Chronic pain (CP), a pathological condition with a large repertory of signs and symptoms, has no recognizable neural functional common hallmark shared by its diverse expressions. The aim of the present research was to identify potential dynamic markers shared in CP models, by using simultaneous electrophysiological extracellular recordings from the rat ventrobasal thalamus and the primary somatosensory cortex. We have been able to extract a neural signature attributable solely to CP, independent from of the originating conditions. This study showed disrupted functional connectivity and increased redundancy in firing patterns in CP models versus controls, and interpreted these signs as a neural signature of CP. In a clinical perspective, we envisage CP as disconnection syndrome and hypothesize potential novel therapeutic appraisal

On the Equivalence of Quadratic APN Functions

Establishing the CCZ-equivalence of a pair of APN functions is generally quite difficult. In some cases, when seeking to show that a putative new infinite family of APN functions is CCZ inequivalent to an already known family, we rely on computer calculation for small values of n. In this paper we present a method to prove the inequivalence of quadratic APN functions with the Gold functions. Our main result is that a quadratic function is CCZ-equivalent to an APN Gold function if and only if it is EA-equivalent to that Gold function. As an application of this result, we prove that a trinomial family of APN functions that exist on finite fields of order 2^n where n = 2 mod 4 are CCZ inequivalent to the Gold functions. The proof relies on some knowledge of the automorphism group of a code associated with such a function.Comment: 13 p