Complex-network analysis of combinatorial spaces: The NK landscape case

We propose a network characterization of combinatorial fitness landscapes by adapting the notion of inherent networks proposed for energy surfaces. We use the well-known family of NK landscapes as an example. In our case the inherent network is the graph whose vertices represent the local maxima in the landscape, and the edges account for the transition probabilities between their corresponding basins of attraction. We exhaustively extracted such networks on representative NK landscape instances, and performed a statistical characterization of their properties. We found that most of these network properties are related to the search difficulty on the underlying NK landscapes with varying values of K.Comment: arXiv admin note: substantial text overlap with arXiv:0810.3492, arXiv:0810.348

GRB Spikes Could Resolve Stars

GRBs vary more rapidly than any other known cosmological phenomena. The lower limits of this variability have not yet been explored. Improvements in detectors would reveal or limit the actual rate of short GRBs. Were microsecond "spike" GRBs to exist and be detectable, they would time-resolve stellar mass objects throughout the universe by their gravitational microlensing effect. Analyzing the time structure of sufficient numbers of GRB spikes would reveal or limit $\Omega_{star}$, $\Omega_{MACHO}$, and/or $\Omega_{baryon}$.Comment: 18 pages, 2 figures, in press: ApJ (Letters

Nitric Oxide Released From Luminal S-nitroso-n-acetylcysteine Increases Gastric Mucosal Blood Flow

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Nitric oxide (NO)-mediated vasodilation plays a key role in gastric mucosal defense, and NO-donor drugs may protect against diseases associated with gastric mucosal blood flow (GMBF) deficiencies. In this study, we used the ex vivo gastric chamber method and Laser Doppler Flowmetry to characterize the effects of luminal aqueous NO-donor drug S-nitroso-N-acetylcysteine (SNAC) solution administration compared to aqueous NaNO2 and NaNO3 solutions (pH 7.4) on GMBF in Sprague-Dawley rats. SNAC solutions (600 mu M and 12 mM) led to a rapid threefold increase in GMBF, which was maintained during the incubation of the solutions with the gastric mucosa, while NaNO2 or NaNO3 solutions (12 mM) did not affect GMBF. SNAC solutions (600 mu M and 12 mM) spontaneously released NO at 37 degrees C at a constant rate of 0.3 or 14 nmol center dot mL(-1)center dot min(-1), respectively, while NaNO2 (12 mM) released NO at a rate of 0.06 nmol center dot mL(-1)center dot min(-1) and NaNO3 (12 mM) did not release NO. These results suggest that the SNAC-induced GMBF increase is due to their higher rates of spontaneous NO release compared to equimolar NaNO2 solutions. Taken together, our data indicate that oral SNAC administration is a potential approach for gastric acid-peptic disorder prevention and treatment.20341094123Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP [2011/50514-5, 2013/07173-8]CNPq [309390/2011-7]FAPESP [2008/57560-0

3C 48: Stellar Populations and the Kinematics of Stars and Gas in the Host Galaxy

We present deep Keck LRIS spectroscopy of the host galaxy of 3C 48. Our observations at various slit positions sample the different luminous components near the quasar, including the apparent tidal tail to the NW and several strong emission line regions. By fitting Bruzual & Charlot (1996) population synthesis models to our spectra, we obtain ages for the most recent major episodes of star formation in various parts of the host galaxy covered by our slits. There is vigorous current star formation in regions just NE and SE of the quasar and post-starburst regions with ages up to ~10^8 years in other parts of the host galaxy, but most of the NW tidal tail shows no sign of significant recent star formation. We use these model fits, together with the kinematics of the stars and gas, to outline a plausible evolutionary history for the host galaxy, its recent starburst activity, the triggering of the quasar, and the interaction of the radio jet with the ambient gas. There is strong evidence that the 3C 48 host is an ongoing merger, and that it is probably near the peak of its starburst activity. Nevertheless, the quasar itself seems to suffer little extinction, perhaps because we are viewing it along a particularly favorable line-of-sight.Comment: 27 pages plus 11 figures (7 postscript, 4 gif). Postscript version including figures (1840 kb) available at http://www.ifa.hawaii.edu/~canaguby/preprints.html . Accepted for publication in Ap

Decoherent Neutrino Mixing, Dark Energy and Matter-Antimatter Asymmetry

A CPT violating decoherence scenario can easily account for all the experimental evidence in the neutrino sector including LSND. In this work it is argued that this framework can also accommodate the Dark Energy content of the Universe, as well as the observed matter-antimatter asymmetry.Comment: 6 pages, no figures, some typos corrected, and discussion modified below eq (3), no effects on conclusion

Mutations in the EXT1 and EXT2 genes in Spanish patients with multiple osteochondromas

Multiple osteochondromas is an autosomal dominant skeletal disorder characterized by the formation of multiple cartilage-capped tumours. Two causal genes have been identified, EXT1 and EXT2, which account for 65% and 30% of cases, respectively. We have undertaken a mutation analysis of the EXT1 and EXT2 genes in 39 unrelated Spanish patients, most of them with moderate phenotype, and looked for genotype-phenotype correlations. We found the mutant allele in 37 patients, 29 in EXT1 and 8 in EXT2. Five of the EXT1 mutations were deletions identified by MLPA. Two cases of mosaicism were documented. We detected a lower number of exostoses in patients with missense mutation versus other kinds of mutations. In conclusion, we found a mutation in EXT1 or in EXT2 in 95% of the Spanish patients. Eighteen of the mutations were novel.Fil: Sarrión, P.. Universidad de Barcelona; EspañaFil: Sangorrin, A.. Hospital Sant Joan de Déu; EspañaFil: Urreizti, R.. Universidad de Barcelona; EspañaFil: Delgado, María Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Artuch, R.. Hospital Sant Joan de Déu; EspañaFil: Martorell, L.. Hospital Sant Joan de Déu; EspañaFil: Armstrong, J.. Hospital Sant Joan de Déu; EspañaFil: Anton, J.. Hospital Sant Joan de Déu; EspañaFil: Torner, F.. Hospital Sant Joan de Déu; EspañaFil: Vilaseca, M. A.. Hospital Sant Joan de Déu; EspañaFil: Nevado, J.. Hospital Universitario La Paz; EspañaFil: Lapunzina, P.. Hospital Universitario La Paz; EspañaFil: Asteggiano, Carla Gabriela. Universidad Nacional de Córdoba; Argentina. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Balcells, S.. Universidad de Barcelona; EspañaFil: Grinberg, D.. Universidad de Barcelona; Españ

(-)-tarchonanthuslactone Exerts A Blood Glucose-increasing Effect In Experimental Type 2 Diabetes Mellitus

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)A number of studies have proposed an anti-diabetic effect for tarchonanthuslactone based on its structural similarity with caffeic acid, a compound known for its blood glucose-reducing properties. However, the actual effect of tarchonanthuslactone on blood glucose level has never been tested. Here, we report that, in opposition to the common sense, tarchonanthuslactone has a glucose-increasing effect in a mouse model of obesity and type 2 diabetes mellitus. The effect is acute and non-cumulative and is present only in diabetic mice. In lean, glucose-tolerant mice, despite a slight increase in blood glucose levels, the effect was not significant.20350385049Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Institute of Chemistry/UNICAMPFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP [proc. 13/07607-8]FAPESP [11/50514-5, 12/09254-2, 10/08673-6, 2009/53606-8

Neutrino Observatories Can Characterize Cosmic Sources and Neutrino Properties

Neutrino telescopes that measure relative fluxes of ultrahigh-energy $\nu_{e}, \nu_{\mu}, \nu_{\tau}$ can give information about the location and characteristics of sources, about neutrino mixing, and can test for neutrino instability and for departures from CPT invariance in the neutrino sector. We investigate consequences of neutrino mixing for the neutrino flux arriving at Earth, and consider how terrestrial measurements can characterize distant sources. We contrast mixtures that arise from neutrino oscillations with those signaling neutrino decays. We stress the importance of measuring $\nu_{e}, \nu_{\mu}, \nu_{\tau}$ fluxes in neutrino observatories.Comment: 9 RevTeX pages, 4 figure