Experimentações artísticas no pensar a construção de identidades a partir da infância e sua interface com a saúde mental

A arte é útil ao ensino a partir de metodologias ativas, sendo capaz de resgatar a história e a memória, como das experiências infantis, que formam a identidade do indivíduo. Objetiva-se descrever a experiência e as reflexões de discentes de medicina a partir da produção e da apresentação de expressões artísticas autobiográficas relacionadas à infância, no contexto do conteúdo curricular de psiquiatria, destacando a relevância da atividade para o autoconhecimento e a formação cidadã e médica. A arte usada para resgatar vivências, promove reflexões e a valorização de sentimentos, afirmando-se como mecanismo terapêutico, o que também favorece o reconhecimento de sua importância na construção da identidade dos sujeitos. Nesse viés, atividades que utilizam da arte na manutenção da saúde mental, nesse caso dos discentes, se mostram relevantes a fim de formar cidadãos e profissionais capazes de estabelecer e fortalecer vínculos, bem como de promover uma escuta ativa e sensível

Mpox: Epidemiological, immunopathogenic aspects and pre- and post-infection management

Mpox or Variola M is a zoonosis caused by viruses of the genus Orthopoxvirus, which also cause common smallpox. It is a disease considered rare and self-limiting, being endemic in African countries. However, in 2022, it gained prominence due to the global outbreak that began when the world was still recovering from the COVID-19 pandemic. Thus, as it is an emerging disease, this review aims to point out general aspects of what is known so far about Mpox, from its immunopathogenesis to current forms of prevention and post-infection care

Growth differentiation factor 11 delivered by dairy Lactococcus lactis strains modulates inflammation and prevents mucosal damage in a mice model of intestinal mucositis

Mucositis is an inflammation of the gastrointestinal mucosa that debilitate the quality of life of patients undergoing chemotherapy treatments. In this context, antineoplastic drugs, such as 5-fluorouracil, provokes ulcerations in the intestinal mucosa that lead to the secretion of pro-inflammatory cytokines by activating the NF-κB pathway. Alternative approaches to treat the disease using probiotic strains show promising results, and thereafter, treatments that target the site of inflammation could be further explored. Recently, studies reported that the protein GDF11 has an anti-inflammatory role in several diseases, including in vitro and in vivo results in different experimental models. Hence, this study evaluated the anti-inflammatory effect of GDF11 delivered by Lactococcus lactis strains NCDO2118 and MG1363 in a murine model of intestinal mucositis induced by 5-FU. Our results showed that mice treated with the recombinant lactococci strains presented improved histopathological scores of intestinal damage and a reduction of goblet cell degeneration in the mucosa. It was also observed a significant reduction of neutrophil infiltration in the tissue in comparison to positive control group. Moreover, we observed immunomodulation of inflammatory markers Nfkb1, Nlrp3, Tnf, and upregulation of Il10 in mRNA expression levels in groups treated with recombinant strains that help to partially explain the ameliorative effect in the mucosa. Therefore, the results found in this study suggest that the use of recombinant L. lactis (pExu:gdf11) could offer a potential gene therapy for intestinal mucositis induced by 5-FU

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

PREVALENCE AND FACTORS ASSOCIATED WITH MOTOR COGNITIVE RISK SYNDROME: SYSTEMATIC REVIEW AND META-ANALYSIS

Objective: To investigate Motor Cognitive Risk Syndrome in the elderly, its prevalence and associated factors

Efficacy of Chitosan gel mucoadhesive containing Doxycycline associated or not to Meloxicam as adjuvant to treatment of gingivitis in dogs with periodontal disease

ABSTRACT. Silva R.C.C., Campos D. R., Oliveira P., Laguna A.G.V., Magalhães V.S., Cid Y.P., Almeida M.B., Scott F.B. & Fernandes J.I. [Efficacy of Chitosan gel mucoadhesive containing Doxycycline associated or not to Meloxicam as adjuvant to treatment of gingivitis in dogs with periodontal disease.] Eficácia de um gel de Quitosano Mucoadesivo contendo Doxiciclina associada ou não ao Meloxicam como coadjuvante ao tratamento da gengivite em cães portadores de doença periodontal. Revista Brasileira de Medicina Veterinária, 38(Supl.2):40-44, 2016. Programa de Pós-Graduação em Medicina Veterinária, Universidade Federal Rural do Rio de Janeiro, BR 465 Km 7, Seropédica, RJ 23897-000, Brasil. E-mail: [email protected] Periodontal disease is the highest occurrence condition in the pet clinic, affecting mainly older animals because of its characteristic of chronicity. Among the clinical signs observed in afflicted animals, gingivitis is the first to be observed. The goal of this study was to develop a mucoadhesive gel, containing doxycycline and meloxicam, and evaluate its efficacy as an adjuvant in the treatment of gingivitis induced by periodontal disease, with a clinical and histopathological rating. Eighteen Beagle dogs presenting gingivitis secondary to periodontal disease were divided into three experimental groups. Group I – animals treated with placebo formulation. Group II – Animals treated with a chitosan gel formulation containing doxycycline. Group III - Animals treated with a chitosan gel formulation containing doxycycline and meloxicam. All animals were treated for seven days, every twelve hours, in the gingival margin of the right maxilla. During the clinic evaluation, only the animals treated with the product containing doxycycline had improved. Contrasting, in the histopathologic evaluation, only animals treated with association of doxycycline and meloxicam presented improvements in their clinical score, although no statistic significance was observed between the groups. The developed formulations were not effective as adjuvants in the treatment of gingivitis induced by periodontal disease treatment

Posterior reversible encephalopathy syndrome: differences between pregnant and non-pregnant patients

Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiologic entity not yet understood, that presents with transient neurologic symptoms and particular radiological findings. Few papers show the differences between pregnant and non-pregnant patients. We review the cases of 38 women diagnosed with PRES, in order to find significant differences between pregnant (18) and non-pregnant (20) patients. We found differences among the age of patients (25.83 years old in pregnant and 29.31 years old in non pregnant; P=0.001); in the mean of highest systolic blood pressure, that was higher in non-pregnant group (185:162 mmHg; P=0.121); and in creatinine levels that was higher in non-pregnant group (3.47:1.04 mg/dL; P=0.001). To our knowledge, just a few papers analyzed whether PRES syndrome presented in the same way in pregnant and non-pregnant patients. The differences and the possible pathophisiology of this syndrome still remain enigmatic