Analgesic and Anti-inflammatory Activities of the Stem Bark of Yellow Flamboyant (Peltophorum pterocarpum)

Peltophorum pterocarpum (family; Fabaceae) is an evergreen perennial crop grown in tropical gardens. Different parts of this tree are being used for the management of many diseases. This study investigated the acute toxicity, analgesic and anti-inflammatory potentials of n-hexane extract of P. pterocarpum stem bark. Acute oral toxicity of n-hexane extract of P. pterocarpum stem bark was investigated using standard method. Analgesic activity was investigated by using acetic acid-induced writhing model, using indomethacin as a reference drug. Antiinflammatory activity of n-hexane extract of P. pterocarpum stem bark was investigated by using formalin-induced paw licking model, using aspirin as standard drug. In the acute toxicity study, mortality was observed at 500 and 2500 mg/kg body weight. In the acetic acid induced writhing test, the n-hexane extract of P. pterocarpum (100 and 200 mg/kg body weight) showed a significant reduction in the number of writhing with 55.5 % and 60 % of inhibition respectively. In formalin-induced rat paw oedema test for acute inflammation, the n-hexane extract of P. pterocarpum in 50, 100 and 200 mg/kg body weight showed 26.00 %, 27.89 % and 32.27 % inhibition of oedema respectively after 4hours, which is comparable to that of standard drug-aspirin (33.59 %). These results validated that the extract of P. pterocarpum possesses significant analgesic and anti-inflammatory properties.Keywords: Peltophorum pterocarpum, acute toxicity, analgesic activity, anti-inflammatory activit

Lactobacillus sp and some fungi from termite nests on kolanut trees had mild antagonistic effects against pathogens isolated from paediatric patients

Background: Residents in a rural suburb of Akure jettisoned antibiotic treatment; sought alternative cure to rising incidence of paediatric infections in 2017 from local herbal dealers, with many residents claiming of better treatment response. We investigated these claims since the local herbal formula included kola nut barks and ground termites.Methodology: Microorganisms associated with termite nests on kola nut trees in the affected community were characterized and identified using standard techniques. The Kirby Bauer disk diffusion was used to evaluate the susceptibility of the bacterial isolates to selected antibiotics. Plasmid profile of multiple antibiotic resistant bacterial isolates (MDRIs) was determined by the Birnboim and Doly method while post plasmid curing antibiotic susceptibility was performed on the MDRIs against the same selected antibiotics. The microorganisms were also evaluated for possible antagonistic effects against Salmonella sp, Staphylococcus aureus and Streptococcus pyogenes isolated from paediatric patients during the period of study using previously described methods.Results: Bacteria (Corynebacterium sp, Streptococcus sp, Acinetobacter sp and Lactobacillus sp) and fungal (Geotrichum condidum, Aspergillus niger, Fusarium oxysporum and Fusarium fujikuroi) were isolated from the termite nests. The antibiotic susceptibility revealed that Corynebacterium sp and Streptococcus sp were multiply antibiotic resistant, and this was confirmed to be plasmid mediated based on plasmid analysis and curing. The Lactobacillus sp, Aspergillus niger, Fusarium fujikuroi and Geotrichum condidum exhibited mild antagonisms against Staphylococcus aureus, Salmonella sp and Streptococcus pyogenes isolated from paediatric patients.Conclusion: This study suggests that termite nests on kola nut trees contain microbes that possess antagonistic actions against pathogens from paediatric patients and that some bacteria associated with termite guts may pose significant risk of increased antibiotic resistance if implicated in human infections.Keywords: Termite nests, Resistance, Antagonistic microbes, Termites, Plasmid, Kola nut tre

Acute Toxicity of Cypermethrin (A Pyrethroid Pesticide) to Post-Fingerlings of the African Mudfish Clarias gariepinus (Burch, 1822)

Post-fingerlings of African mudfish, Clarias gariepinus (Burch, 1822), (mean weight 12.6+0.8g SEM, mean; total length, 10.4+1.1cm SEM) were exposed to different concentrations (0, 0.025, 0.05, 0.10 and 0.20 ppm) of cypermethrin in a static renewal bioassay to determine the 96hrLC50. Fish treated with cypermethrin showed abnormal behavior characterised by restlessness, uncoordinated movements, loss of equilibrium, gulping of air, period of quiescence and then death. The sub-lethal responses of the fish to the pesticide were more pronounced on opercular ventilation (y=64.45+115.6x) than on tail beat frequency (y=442+84.64x). The 96hrLC50 and safe concentration were 0.034 and 0.0034 respectively, indicating that the pesticide is highly toxic to this non-target fish. [IJARD Vol.3 2002: 144-149

Implication of construction contract termination for infrastructural development in Ekiti State Local Government Areas, Nigeria

Local Government Areas are the third tier of government in Nigeria and the closest to the people. The Local Government Areas are charged with the responsibility of delivering the dividend of democracy to meet the fundamental needs of the local community through the provision of infrastructural facilities. This study assessed the causes and effects of the termination of construction contracts in the 16 Local Government Areas in Ekiti State, Nigeria. The exploratory research design was employed with a purposive sampling of construction project contracts awarded in the Local Government Areas of Ekiti State, Nigeria between 2006 and 2015. A structured questionnaire in Likert’s scale was used for data collection and with a response rate of 90%. Data were analysed using Spearman’s rank correlation coefficient (r), Percentages and Importance Index Rate (I.I.R.). Results show that Lack of continuity, design error, lack of fund by the local government council, failure of prompt payment, change of executive leadership were among identified factors responsible for contract termination in the study area. The implication of contract termination from the data analysis include delayed completion, abandonment of the project, variance in final cost and cost overrun, change in the quality of the project when completed due climatic effect. It is concluded the rate of construction contract termination in LGAs in Ekiti state is approximately 1 in 5, these terminations are due to project related, political and administrative factors respectively. It therefore recommended that there is need for concerted effort to reduce the rate of construction contract termination in LGAs in the state. There is also need to formulate policies to mitigate the effect of change in government on construction contracts and to ensure that contracts terminated are promptly re-awarded to avoid delay and abandonment. This will afford the people at the grassroots to effectively enjoy the benefits of these infrastructural facilities.Keywords: Contract termination, Local Government Areas, Infrastructure, Ekiti-State, Nigeri

Richness, composition and trophic groups of an avian community in the Pernambuco Endemism Centre, Alagoas, Brazil

In northeastern Brazil, the reduction of the natural forest cover to a series of small, isolated fragments has had negative consequences for the local avian fauna, in particular, a loss of the more specialized species, while the populations of some generalists have tended to increase. The present study focuses on the composition and trophic groups of a bird community on a farm in the northeastern Brazilian state of Alagoas. Monthly surveys were conducted between November 2008 and October 2009, based on mist-netting and systematic observations. Overall, 112 species were recorded, of which 76 were associated with the two forest fragments surveyed, while all the others were observed exclusively in the surrounding matrix of pasture and orchards. The bird community presented a predominance of insectivorous species, followed by omnivores. However, specialized trunk-creeping and understory insectivores accounted for only around 15% of the species in this feeding category. The reduced diversity of other guilds and species with more specialized diets, and the complete absence of sensitive species such as large parrots and raptors, reflects the severe fragmentation and degradation of the local forests, which has greatly reduced the availability of dietary resources and breeding sites

Pattern analysis on grain yield performance of Chinese and CIMMYT spring wheat cultivars sown in China and CIMMYT

Understanding the relationships among testing environments is essential for better targeting cultivars to production environments. To identify patterns of cultivar, environment, cultivar-by-environment interactions, and opportunities for indirect selection for grain yield, a set of 25 spring wheat cultivars from China and the International Maize and Wheat Improvement Center (CIMMYT) was evaluated in nine environments in China and four management environments at CIMMYT in Cd. Obregon, Mexico, during two wheat seasons. Genetic background and original environment were the main factors influencing grain yield performance of the cultivars. Baviacora M 92, Xinchun 2 and Xinchun 6 showed relatively more stable and higher grain yields, whereas highly photoperiod sensitive cultivars Xinkehan 9, Kefeng 6 and Longmai 19 proved consistently inferior across environments, except in Harbin and Keshan, the two high latitude environments. Longmai 26, also from high latitude environments in the northeastern Heilongjiang province, was however probably not as photoperiodicly sensitive as other cultivars; from that region, and produced much higher grain yield and expressed a broader adaptation. None of the environments reported major diseases. Pattern analyses revealed that photoperiod response and planting option on beds were the two main factors underlying the observed interactions for grain yield. The production environment of planting on the flat in Mexico grouped together with Huhhot and Urumqi in both wheat seasons, indicating an indirect response to selection for grain yield in this CIMMYT managed environment could benefit the two Chinese environments. Both the environment of planting on the flat with Chinese Hejin and Yongning, and the three CIMMYT enviromnents planting on raised beds with Chinese Yongning grouped together only in one season, showing that repeatability may not be stable in this case

Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria

Background Although diffuse intrinsic pontine glioma (DIPG) carries the worst prognosis of all pediatric brain tumors, studies on prognostic factors in DIPG are sparse. To control for confounding variables in DIPG studies, which generally include relatively small patient numbers, a survival prediction tool is needed. Methods A multicenter retrospective cohort study was performed in the Netherlands, the UK, and Germany with central review of clinical data and MRI scans of children with DIPG. Cox proportional hazards with backward regression was used to select prognostic variables (P <. 05) to predict the accumulated 12-month risk of death. These predictors were transformed into a practical risk score. The model's performance was validated by bootstrapping techniques. Results A total of 316 patients were included. The median overall survival was 10 months. Multivariate Cox analysis yielded 5 prognostic variables of which the coefficients were included in the risk score. Age ≤3 years, longer symptom duration at diagnosis, and use of oral and intravenous chemotherapy were favorable predictors, while ring enhancement on MRI at diagnosis was an unfavorable predictor. With increasing risk score categories, overall survival decreased significant