Local Attentional Bias Increases Approach Motivation: Evidence from Event-Related Potentials and Frequency Analyses

Over twenty years of research have examined the cognitive consequences of positive affect states, and suggested that positive affect leads to a broadening of cognition. However, this research has primarily examined positive affect that is low in approach motivational intensity (e.g. contentment). In my program of research, I have systematically examined positive affect that varies in approach motivational intensity, and found that positive affect high in approach motivation (e.g. desire) narrow cognition, whereas positive affect low in approach motivation broaden cognition. In this dissertation, I will review past models and present a motivational dimension model of affect that expands understanding of how affective states influence attentional and cognitive breadth. I then review a body of research that has varied the motivational intensity of positive and negative affect and found that affect of low motivational intensity broadens cognitive processes, whereas affect of high motivational intensity narrows cognitive processes. Furthermore, a bi-directional link exists between attentional narrowing and approach motivation, such that a narrowed attentional focus to appetitive stimuli causes greater approach motivation than a broadened attentional focus

Approach-motivated positive affect reduces broadening of attention

Research has found that positive affect broadens attention. However, the type of positive affect previously manipulated has been low in approach motivation. High approach-motivated positive affect should reduce the breadth of attention, as organisms shut out irrelevant perceptions and cognitions while they approach and attempt to acquire desired objects. Three studies examined the attentional consequences of approach-motivated positive affect states. Consistent with predictions, participants showed less global attentional focus after viewing approach-motivating positive pictures as compared to neutral pictures (Studies 1 and 2). Specifically, Study 1 used approach-motivating pictures of appetitive desserts, while Study 2 used pictures of cute animals. Neutral pictures were of varying neutral objects. Study 3 manipulated both affect and approach motivation. Less global focus was found for participants who viewed the approach-motivating pictures and had the expectancy to obtain the items as compared to other participant groups. The results indicate that high approach-motivated positive affect reduces the breadth of attentional focus, in contrast to the broadening of attentional focus that has been found with low approach-motivated positive affect

Exploring content and psychometric validity of newly developed assessment tools for itch and skin pain in atopic dermatitis.

BackgroundAtopic dermatitis (AD) is a common skin disorder characterized by chronic inflammation, altered skin barrier function, and inflammatory cell skin infiltration that decreases health-related quality of life (HRQoL). The study objective was to understand the patient perspective of AD burden and determine suitable patient-reported outcome (PRO) measures.MethodsThis mixed methods study involved the collection of qualitative and quantitative information from adults (≥ 18 years old) and adolescents (12 - 17 years old) with clinician-confirmed AD regarding their experiences of AD symptoms and its impact on HRQoL. The first part of the study included three stages: in-person concept elicitation (CE) interviews, a 2-week daily electronic diary (eDiary) study, and in-person cognitive debriefing (CD) interviews. An Itch numeric rating scale (NRS) (v1.0) and a Skin Pain NRS (v1.0) evaluation during CD interviews required participants to think about their 'worst' itch and 'worst' skin pain in the past 24 h. Other PRO measures allowed for psychometric testing. The second part of the study involved telephone-depth interviews (TDIs) and qualitative feedback from participants who had not participated in the CD interviews. Qualitative data were thematically analyzed. Psychometric evaluation of NRS measures was performed using eDiary data.ResultsIn the CE interviews, itch and/or itching and skin pain were the most prevalent symptoms consistently discussed by participants. Both NRS measures demonstrated strong psychometric reliability and were applicable across ages with suitable concurrent validity. During the CD interviews, some participants focused their answers on their 'average' itch/itching in the past 24 h, rather than their 'worst' itch. Some participants answered the Skin Pain NRS thinking about general pain or other types of pain, rather than skin pain specifically. Consequently, modifications to both measures addressed these issues and re-tested as paper-and-pen versions in subsequent TDIs. Itch NRS (v2.0) modifications helped participants focus on their worst itching. Most participants preferred Skin Pain NRS v2.0b, which included skin pain descriptors.ConclusionsItching and skin pain are the most important and relevant AD symptoms. The Itch NRS (v2.0) and Skin Pain NRS (v2.0b) appear to be appropriate endpoints for the assessment of itching and skin pain severity for clinical trials with adults and adolescents with AD

Paediatric autoimmune encephalopathies:Clinical features, laboratory investigations and outcomes in patients with or without antibodies to known central nervous system autoantigens

Objective: To report the clinical and investigative features of children with a clinical diagnosis of probable autoimmune encephalopathy, both with and without antibodies to central nervous system antigens. Method: Patients with encephalopathy plus one or more of neuropsychiatric symptoms, seizures, movement disorder or cognitive dysfunction, were identified from 111 paediatric serum samples referred from five tertiary paediatric neurology centres to Oxford for antibody testing in 2007-2010. A blinded clinical review panel identified 48 patients with a diagnosis of probable autoimmune encephalitis whose features are described. All samples were tested/retested for antibodies to N-methyl-D-aspartate receptor (NMDAR), VGKC-complex, LGI1, CASPR2 and contactin-2, GlyR, D1R, D2R, AMPAR, GABA(B)R and glutamic acid decarboxylase. Results Seizures (83%), behavioural change (63%), confusion (50%), movement disorder (38%) and hallucinations (25%) were common. 52% required intensive care support for seizure control or profound encephalopathy. An acute infective organism (15%) or abnormal cerebrospinal fluid (32%), EEG (70%) or MRI (37%) abnormalities were found. One 14-year-old girl had an ovarian teratoma. Serum antibodies were detected in 21/48 (44%) patients: NMDAR 13/48 (27%), VGKC-complex 7/48(15%) and GlyR 1/48(2%). Antibody negative patients shared similar clinical features to those who had specific antibodies detected. 18/34 patients (52%) who received immunotherapy made a complete recovery compared to 4/14 (28%) who were not treated; reductions in modified Rankin Scale for children scores were more common following immunotherapies. Antibody status did not appear to in fluence the treatment effect. Conclusions: Our study outlines the common clinical and paraclinical features of children and adolescents with probable autoimmune encephalopathies. These patients, irrespective of positivity for the known antibody targets, appeared to benefit from immunotherapies and further antibody targets may be defined in the future

Approach motivation and positive affect

Motivation is an essential part of positive affect which is often overlooked by emotion scientists. In this article we aim to show commonalities and differences between approach motivation and positive affect and highlight dissociations between these often-confounded phenomena. We will start by providing (working) definitions of concepts related to approach motivation and positive affect. We will then discuss how approach motivation can be unique from positive affect and how extreme levels of approach motivation can disassociate from positive affect. This will be followed by a short review on how approach motivation as one dimension of positive affect impacts cognitive scope. Finally, we will address how differential aspects of reward prospect relate to approach motivation and positive affect and modulate their impact on cognition

Frontal Asymmetry as a Neural Correlate of Motivational Conflict

Motivational systems of approach, avoidance, and inhibition are fundamental to human behavior. While past research has linked approach motivation with greater relative left frontal asymmetry, many attempts to link avoidance motivation with greater relative right frontal asymmetry have been mixed. These mixed effects could be due to coactivation of the avoidance and behavioral inhibition system (BIS). Much recent evidence indicates that the behavioral inhibition system may be associated with greater relative right frontal activation. The current review examines evidence linking traits associated with the behavioral inhibition system with resting right frontal asymmetry. Other research links individual differences associated with the behavioral inhibition system with state changes in relative right frontal asymmetry. Moreover, activation of the behavioral inhibition system, but not activation of withdrawal motivation, increases greater relative right frontal asymmetry. Together, this work highlights the role of relative frontal asymmetry as a neural correlate in motivational conflict and helps to disentangle behavioral inhibition from avoidance motivation