NEREA: Named entity recognition and disambiguation exploiting local document repositories

In this work, we describe the design, development, and deployment of NEREA (Named Entity Recognizer for spEcific Areas), an automatic Named Entity Recognizer and Disambiguation system, developed in collaboration with professional documentalists. The aim of NEREA is to keep accurate and current information about the entities mentioned in a local repository, and then support building appropriate infoboxes, setting out the main data of these entities. It achieves a high performance thanks to the use of classification resources belonging to the local database. With this aim, the system performs tasks of named entity recognition and disambiguation by using three types of knowledge bases: local classification resources, global databases like DBpedia, and its own catalog created by NEREA. The proposed method has been validated with two different datasets and its operation has been tested in English and Spanish. The working methodology is being applied in a real environment of a media with promising results

Activin/TGFβ and BMP crosstalk determines digit chondrogenesis

AbstractThe progress zone (PZ) is a specialized area at the distal margin of the developing limb where mesodermal cells are kept in proliferation and undifferentiated, allowing limb outgrowth. At stages of digit morphogenesis the PZ cells can undergo two possible fates, either aggregate initiating chondrogenic differentiation to configure the digit blastemas, or to die by apoptosis if they are incorporated in the interdigital mesenchyme. While both processes are controlled by bone morphogenetic proteins (BMPs) the molecular basis for such contrasting differential behavior of the autopodial mesoderm remains unknown. Here we show that a well-defined crescent domain of high BMP activity located at the tip of the forming digits, which we termed the digit crescent (DC), directs incorporation and differentiation of the PZ mesenchymal cells into the digit aggregates. The presence of this domain does not correlate with an exclusive expression domain of BMP receptors and its abrogation by surgical approaches or by local application of BMP antagonists is followed by digit truncation and cell death. We further show that establishment of the DC is directed by Activin/TGFβ signaling, which inhibits Smad 6 and Bambi, two specific BMP antagonists expressed in the interdigits and progress zone mesoderm. The interaction between Activin/TGFβ and BMP pathways at the level of DC promotes the expression of the chondrogenic factor SOX9 accompanied by a local decrease in cell proliferation. Characteristically, the DC domain is asymmetric, it being extended towards the posterior interdigit. The presence of the DC is transitorily dependent of the adjacent posterior interdigit and its maintenance requires also the integrity of the AER

Activin/TGFβ and BMP crosstalk determines digit chondrogenesis

AbstractThe progress zone (PZ) is a specialized area at the distal margin of the developing limb where mesodermal cells are kept in proliferation and undifferentiated, allowing limb outgrowth. At stages of digit morphogenesis the PZ cells can undergo two possible fates, either aggregate initiating chondrogenic differentiation to configure the digit blastemas, or to die by apoptosis if they are incorporated in the interdigital mesenchyme. While both processes are controlled by bone morphogenetic proteins (BMPs) the molecular basis for such contrasting differential behavior of the autopodial mesoderm remains unknown. Here we show that a well-defined crescent domain of high BMP activity located at the tip of the forming digits, which we termed the digit crescent (DC), directs incorporation and differentiation of the PZ mesenchymal cells into the digit aggregates. The presence of this domain does not correlate with an exclusive expression domain of BMP receptors and its abrogation by surgical approaches or by local application of BMP antagonists is followed by digit truncation and cell death. We further show that establishment of the DC is directed by Activin/TGFβ signaling, which inhibits Smad 6 and Bambi, two specific BMP antagonists expressed in the interdigits and progress zone mesoderm. The interaction between Activin/TGFβ and BMP pathways at the level of DC promotes the expression of the chondrogenic factor SOX9 accompanied by a local decrease in cell proliferation. Characteristically, the DC domain is asymmetric, it being extended towards the posterior interdigit. The presence of the DC is transitorily dependent of the adjacent posterior interdigit and its maintenance requires also the integrity of the AER

Gas Dynamic Virtual Nozzle for Generation of Microscopic Droplet Streams

As shown by Ganan-Calvo and co-workers, a free liquid jet can be compressed in iameter through gas-dynamic forces exerted by a co-flowing gas, obviating the need for a solid nozzle to form a microscopic liquid jet and thereby alleviating the clogging problems that plague conventional droplet sources of small diameter. We describe in this paper a novel form of droplet beam source based on this principle. The source is miniature, robust, dependable, easily fabricated, and eminently suitable for delivery of microscopic liquid droplets, including hydrated biological samples, into vacuum for analysis using vacuum instrumentation. Monodisperse, single file droplet streams are generated by triggering the device with a piezoelectric actuator. The device is essentially immune to clogging

Transforming growth factor beta signaling: The master sculptor of fingers

Transforming growth factor beta (TGF?) constitutes a large and evolutionarily conserved superfamily of secreted factors that play essential roles in embryonic development, cancer, tissue regeneration, and human degenerative pathology. Studies of this signaling cascade in the regulation of cellular and tissue changes in the three-dimensional context of a developing embryo have notably advanced in the understanding of the action mechanism of these growth factors. In this review, we address the role of TGF? signaling in the developing limb, focusing on its essential function in the morphogenesis of the autopod. As we discuss in this work, modern mouse genetic experiments together with more classical embryological approaches in chick embryos, provided very valuable information concerning the role of TGF? and Activin family members in the morphogenesis of the digits of tetrapods, including the formation of phalanxes, digital tendons, and interphalangeal joints. We emphasize the importance of the Activin and TGF? proteins as digit inducing factors and their critical interaction with the BMP signaling to sculpt the hand and foot morphology

Kangú park

TESIS PARA OPTAR AL GRADO DE MAGÍSTER EN ADMINISTRACIÓN (MBA)Alejandra Gañan [Parte I] , Yaqueline Aravena A. [Parte II]el siguiente documento se presenta Kangú Park, parque de trampolines para la entretención familiar que queda ubicado en el sector de Santa Elvira a 3 km de la ciudad de Valdivia. Este proyecto nace debido a la necesidad detectada en esta localidad que se identifica en la encuesta realizada al 100% de las personas encuestadas, que cree que es necesario un centro de entretención para toda la familia, ya que en Valdivia existen pocas alternativas de entretención que por lo general se buscan dentro de casa por medio de pantallas. Kangú Park, es diferente ya que tiene una propuesta de entretención familiar, en donde se promueve la vida sana y el deporte por medio de la entretención, en donde busca posicionarse como la mejor opción de entretención familiar de la ciudad de Valdivia a un precio justo, para esto se realizarán alianzas estratégicas con colegios, universidades o instituciones similares. En este documento se encuentra información relevante respecto de la industria de la entretención, nuevas tendencias, modelo de negocio, plan de marketing, plan operacional y proyecciones financieras realizadas en un periodo de 5 años. Respecto de las estimaciones financieras realizadas, Kangú Park requiere una inversión inicial de M$163.754, un capital de trabajo de M$9.299, los cuales tienen un payback de 2,08 años, estados de resultado positivo en la evaluación de 5 años una TIR de 42% y un VAN de M$176.665