Polymorphism: an evaluation of the potential risk to the quality of drug products from the Farmácia Popular Rede Própria

Polymorphism in solids is a common phenomenon in drugs, which can lead to compromised quality due to changes in their physicochemical properties, particularly solubility, and, therefore, reduce bioavailability. Herein, a bibliographic survey was performed based on key issues and studies related to polymorphism in active pharmaceutical ingredient (APIs) present in medications from the Farmácia Popular Rede Própria. Polymorphism must be controlled to prevent possible ineffective therapy and/or improper dosage. Few mandatory tests for the identification and control of polymorphism in medications are currently available, which can result in serious public health concerns

The crystal structure of Aspartame Anhydrate from powder diffraction data.

Contains fulltext : 35210.pdf (publisher's version ) (Closed access

Structures and conversions of pharmaceutical compounds

Contains fulltext : 75814.pdf (publisher's version ) (Open Access)Radboud Universiteit Nijmegen, 6 april 2009Promotor : Vlieg, E. Co-promotor : Gelder, R. de224 p

Studies on the hydrate formation of two narcotic antagonists by (real-time) powder diffraction

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FIDDLE: A method for simultaneous indexing and structure solution from powder diffraction data

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The hydration/dehydration behavior of asprtame revisited

Contains fulltext : 72482.pdf (publisher's version ) (Closed access)8 p

Structural diversity of synthetic estrogen solvates.

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Structural diversity of ethinyl estradiol solvates

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