Distribution of endothelial cell protein C/activated protein C receptor (EPCR) during mouse embryo development.

The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombomodulin.thrombin complex. Deletion of the EPCR gene in mice has been reported to lead to embryonic lethality before embryonic day 10 (E10.0). To identify potential mechanisms responsible for this lethality, we performed an immunohistological analysis of EPCR distribution during mouse embryogenesis. EPCR was detected in the trophoblast giant cells at the feto-maternal boundary from E7.5 and at later time points in the trophoblasts of the placenta, suggesting a role in the haemostatic regulation of the maternal blood that irrigates these surfaces. In the embryo, EPCR was weakly detected in aortic endothelial cells from E13.5. Thereafter, EPCR levels increased in certain large blood vessels endothelial cells suggesting that the specificity of EPCR to large vessels is conferred in utero. However, not until postnatal day 7 did the intensity and distribution of EPCR staining mimic that observed in adult mice

An advanced meshless method for time fractional diffusion equation

Recently, because of the new developments in sustainable engineering and renewable energy, which are usually governed by a series of fractional partial differential equations (FPDEs), the numerical modelling and simulation for fractional calculus are attracting more and more attention from researchers. The current dominant numerical method for modeling FPDE is Finite Difference Method (FDM), which is based on a pre-defined grid leading to inherited issues or shortcomings including difficulty in simulation of problems with the complex problem domain and in using irregularly distributed nodes. Because of its distinguished advantages, the meshless method has good potential in simulation of FPDEs. This paper aims to develop an implicit meshless collocation technique for FPDE. The discrete system of FPDEs is obtained by using the meshless shape functions and the meshless collocation formulation. The stability and convergence of this meshless approach are investigated theoretically and numerically. The numerical examples with regular and irregular nodal distributions are used to validate and investigate accuracy and efficiency of the newly developed meshless formulation. It is concluded that the present meshless formulation is very effective for the modeling and simulation of fractional partial differential equations

Direct Evidence from Spitzer for a low-luminosity AGN at the center of the Elliptical Galaxy NGC 315

We present the {\it Spitzer} Space Telescope InfraRed Array Camera (IRAC) and Multiband Imaging Photometer (MIPS) observations of the elliptical galaxy NGC 315. After removal of the host galaxy's stellar emission, we detected for the first time an infrared-red nucleus in NGC 315. We measured the spectral energy distribution (SED) for this active nucleus with wavelength range covering from radio to X-ray, and obtained the bolometric luminosity of $\rm L_{bol} \approx 1.9 \times 10^{43} ergs s^{-1}$, corresponding to an extremely low Eddington ratio (L/L$_{\rm Edd}$) of 4.97 $\times$ 10$^{-4}$. Our results confirm that the physical nature of the nucleus of NGC 315 is a low-luminosity AGN, consistent with the recent optical and {\it Chandra} X-ray observations.Comment: 4 pages, accepted for publication in ApJ Letter

Extremely Correlated Fermi Liquid Description of Normal State ARPES in Cuprates

The normal state single particle spectral function of the high temperature superconducting cuprates, measured by the angle resolved photoelectron spectroscopy (ARPES), has been considered both anomalous and crucial to understand. Here we show that an unprecedentedly detailed description of the data is provided by a spectral function arising from the Extremely Correlated Fermi Liquid state of the t-J model proposed recently by Shastry. The description encompasses both laser and conventional synchrotron ARPES data on optimally doped Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$, and also conventional synchrotron ARPES data on the La$_{1.85}$Sr$_{0.15}$CuO$_4$ materials. {\em It fits all data sets with the same physical parameter values}, satisfies the particle sum rule and successfully addresses two widely discussed "kink" anomalies in the dispersion.Comment: Published version, 5 figs; published 29 July (2011

Neutrino masses, leptogenesis and dark matter in hybrid seesaw

We suggest a hybrid seesaw model where relatively ``light''right-handed neutrinos give no contribution to the neutrino mass matrix due to a special symmetry. This allows their Yukawa couplings to the standard model particles to be relatively strong, so that the standard model Higgs boson can decay dominantly to a left and a right-handed neutrino, leaving another stable right-handed neutrino as cold dark matter. In our model neutrino masses arise via the type-II seesaw mechanism, the Higgs triplet scalars being also responsible for the generation of the matter-antimatter asymmetry via the leptogenesis mechanism.Comment: 4 page