Stress oxydant chez des patients en nutrition parentérale au long cours (rôle de l'émulsion lipidique)

LYON1-BU Santé (693882101) / SudocSudocFranceF

Infection ostéoarticulaire multifocale à salmonella non typhi chez une enfant drépanocytaire

Nous présentons ici un cas rare d'ostéoarthrite multifocale à salmonella non typhi chez une jeune enfant drépanocytaire HbSS. L'évolution a été marquée par une dissémination multi articulaire de la bactérie sous traitement, et une évolution chronique puisque l'apyrexie n'a été obtenue qu'après 2 mois et la guérison 4 mois d'antibiothérapie. L'enfant a présenté au décours d'une anesthésie pour ponction articulaire un arrêt cardio-respiratoire, son évolution neurologique a été marquée par l'installation d'une encéphalopathie d'origine multifactorielle, elle garde, 9 mois après le début de cette infection de très lourdes séquelles neuromotrices. Cette observation, outre sa rareté, illustre les difficultés de prise en charge de ces enfants drépanocytaires pour les pédiatres, les infectiologues, les hématologues, les anesthésistes, les chirurgiens infantiles et les médecins de la douleur.NANTES-BU Médecine pharmacie (441092101) / SudocSudocFranceF

Isolation and characterization of authentic Phe-Met-Arg-Phe-NH2 and the novel Phe-Thr-Arg-Phe-NH2 peptide from Nereis diversicolor

International audienc

REview of potentially inappropriate MEDIcation pr[e]scribing in Seniors (REMEDI[e]S): French implicit and explicit criteria

International audiencePurpose To establish a consensus on both explicit and implicit criteria in order to identify potentially inappropriate prescribing (PIP) in French older people aged 75 years and over or 65 years and over with multimorbidity. Methods Fifteen experts in geriatrics, general practice, pharmacy, and clinical pharmacology were involved in a two-round Delphi survey to assess preliminary explicit and implicit criteria based on an extensive literature review and up-to-date evidence data. Experts were asked to rate their level of agreement using a 5-level Likert scale for inclusion of criteria and also for rationale and therapeutic alternatives. A consensus was considered as reached if at least 75% of the experts rated criteria as "strongly agreed" or "agreed." Results The new tool included a seven-step algorithm (implicit criteria) encompassing the three main domains that define PIP (i.e. overprescribing, underprescribing, and misprescribing) and 104 explicit criteria. Explicit criteria were divided into 6 tables related to inappropriate drug duplications (n = 7 criteria), omissions of medications and/or medication associations (n = 16), medications with an unfavourable benefit/risk ratio and/or a questionable efficacy (n = 39), medications with an unsuitable dose (n = 4) or duration (n = 6), drug-disease (n = 13), and drug-drug interactions (n = 19). Conclusion The REMEDI[e]S tool (REview of potentially inappropriate MEDIcation pr[e]scribing in Seniors) is an original mixed tool, adapted to French medical practices, aimed at preventing PIP both at the individual level in clinical practice and the population level in large-scale studies. Therefore, its use could contribute to an improvement in healthcare professionals' prescribing practices and safer care in older adults

Nocardia Arthritis

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