Explaining Political Violence Against Civilians in Northern Ireland: A Contention-Oriented Approach

In contrast to prevalent theories of terrorism, this study develops a contention-oriented approach where levels and forms of political violence against civilians depend upon: (1) the strategies of combatants; (2) the means of contention; (3) the locations of allies and opponents; (4) the collective identities of combatants; and (5) the dynamics of contention, including whether or not representatives of paramilitary organizations are included in formal peace processes. Quantitative analyses of a multi-source database of civilian deaths taking place in Northern Ireland between 1966 and 2006 offer preliminary support for this approach. The study underscores the insights provided by theories and methods used in the fields of social movements research and peace and conflict studies

A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade

Autophagy depends on the E2 enzyme, Atg3, functioning in a conserved E1-E2-E3 trienzyme cascade that catalyzes lipidation of Atg8-family ubiquitin-like proteins (UBLs). Molecular mechanisms underlying Atg8 lipidation remain poorly understood despite association of Atg3, the E1 Atg7, and the composite E3 Atg12-Atg5-Atg16 with pathologies including cancers, infections and neurodegeneration. Here, studying yeast enzymes, we report that an Atg3 element we term E123IR (E1, E2, and E3-interacting region) is an allosteric switch. NMR, biochemical, crystallographic and genetic data collectively indicate that in the absence of the enzymatic cascade, the Atg3(E123IR) makes intramolecular interactions restraining Atg3's catalytic loop, while E1 and E3 enzymes directly remove this brace to conformationally activate Atg3 and elicit Atg8 lipidation in vitro and in vivo. We propose that Atg3's E123IR protects the E2 similar to UBL thioester bond from wayward reactivity toward errant nucleophiles, while Atg8 lipidation cascade enzymes induce E2 active site remodeling through an unprecedented mechanism to drive autophagy

Act like a lady: the impact of gender identity on American Sign Language – English interpreters

In this study, trends in gender-related traits among practitioners of American Sign Language – English interpreting are investigated. The impact of gender identity on practitioners’ perceptions of their role and professional experiences is also explored. Limited research exists to address issues of gender within the American Sign Language – English interpreting field but is largely focused on differences in discourse among male and female practitioners. Data for this study was collected through quantitative and qualitative means: an online survey incorporating the Bem Sex-Role Inventory and interviews with five practitioners of American Sign Language – English interpreting. A review of related literature supported the notion that while societal views of gender have shifted over time, certain qualities and characteristics remain valued for men and women. Research on female-dominated professions shows men experience gender identity privilege in the workplace. While this study shows that male and female practitioners may value or possess similar traits and characteristics, female practitioners experience gender identity oppression in a manner that male practitioners do not, especially related to their bodies and expressions of femininity. The experiences of female practitioners creates an additional layer of consideration that must be addressed prior to focusing on the myriad considerations inherent in the work of American Sign Language – English interpreters. Educators are advised to take current classroom practices into consideration for supporting all students, regardless of gender identity, and practitioners are encouraged to seek diverse communities of practice. These communities may provide the forum during which practitioners can engage in discussions of identity oppression and potential mitigating strategies

Alien Registration- Campbell, Grace B. (Brewer, Penobscot County)

https://digitalmaine.com/alien_docs/11378/thumbnail.jp

Chuck Gramly: Heart, Commitment, Respect

Chuck Gramly has been an inspiration to several generations of American Sign Language (ASL)/English interpreters in the Central Ohio community. His leadership, guidance, and passion for ASL and the Deaf community lives in the hearts of all whom have had the pleasure of knowing him. As an interpreter and interpreter educator, Chuck made his mark on the budding profession of interpreting that has come to be what it is today. Through his teaching, involvement in the local community as well as state and national organizations, Chuck’s life work has ignited a passion in others that boils down to three things: respect for language and community, respect for the profession, and respect for one another

Mythological Links to Shinto Architecture

The practice of shrine worship has been present in Japan for centuries. The construction of shrines emanated from the belief that the kami, or spirits, needed a dwelling place. The many elements of the shrine have a connection to an aspect of the Shinto mythology. This investigation examines the major elements of a Shinto shrine and the mythological significance of each