An Unbiased CO Survey Toward the Northern Region of the Small Magellanic Cloud with the Atacama Compact Array. II. CO Cloud Catalog

The nature of molecular clouds and their statistical behavior in sub-solar metallicity environments are not fully explored yet. We analyzed an unbiased CO($J$ = 2-1) survey data at a spatial resolution of $\sim$2 pc in the northern region of the Small Magellanic Cloud (SMC) with the Atacama Compact Array to characterize the CO cloud properties. A cloud decomposition analysis identified 426 spatially/velocity-independent CO clouds and their substructures. Based on the cross-matching with known infrared catalogs by Spitzer and Herschel, more than 90% CO clouds show spatial correlations with point sources. We investigated the basic properties of the CO clouds and found that the radius-velocity linewidth ($R$-$\sigma_{v}$) relation follows the Milky Way (MW) like power-low exponent, but the intercept is $\sim$1.5 times lower than that in the MW. The mass functions ($dN/dM$) of the CO luminosity and virial mass are characterized by an exponent of $\sim$1.7, which is consistent with previously reported values in the Large Magellanic Cloud and MW.Comment: 18 pages, 9 figures. Accepted for publication in The Astrophysical Journa

Simultaneous Screening of Multiple Mutations by Invader Assay Improves Molecular Diagnosis of Hereditary Hearing Loss: A Multicenter Study

Although etiological studies have shown genetic disorders to be a common cause of congenital/early-onset sensorineural hearing loss, there have been no detailed multicenter studies based on genetic testing. In the present report, 264 Japanese patients with bilateral sensorineural hearing loss from 33 ENT departments nationwide participated. For these patients, we first applied the Invader assay for screening 47 known mutations of 13 known deafness genes, followed by direct sequencing as necessary. A total of 78 (29.5%) subjects had at least one deafness gene mutation. Mutations were more frequently found in the patients with congenital or early-onset hearing loss, i.e., in those with an awareness age of 0–6 years, mutations were significantly higher (41.8%) than in patients with an older age of awareness (16.0%). Among the 13 genes, mutations in GJB2 and SLC26A4 were mainly found in congenital or early-onset patients, in contrast with mitochondrial mutations (12S rRNA m.1555A>G, tRNA(Leu(UUR)) m.3243A>G), which were predominantly found in older-onset patients. The present method of simultaneous screening of multiple deafness mutations by Invader assay followed by direct sequencing will enable us to detect deafness mutations in an efficient and practical manner for clinical use